Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data

Journal of Bioscience and Bioengineering

Volumn 116, Issue 6, 2013, Pages 768-773

  Takahashi, Hiro ^a,b,c   Kaniwa, Nahoko ^d   Saito, Yoshiro ^d   Sai, Kimie ^d   Hamaguchi, Tetsuya ^e   Shirao, Kuniaki ^e   Shimada, Yasuhiro ^e   Matsumura, Yasuhiro ^f   Ohtsu, Atsushi ^f   Yoshino, Takayuki ^f   Takahashi, Anna ^b   Odaka, Yoko ^c   Okuyama, Misuzu ^c   Sawada, Jun ichi ^d,g   Sakamoto, Hiromi ^c   Yoshida, Teruhiko ^c  

^a CHIBA UNIVERSITY   (Japan)

^b CHUBU UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e NATIONAL CANCER CENTER HOSPITAL   (Japan)

^f NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^g PHARMACEUTICALS AND MEDICAL DEVICES AGENCY   (Japan)

Author keywords

Bioinformatics; Fluoropyrimidine; Gastric cancer; Genome wide association study; Single nucleotide polymorphisms

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTORS; FLUOROPYRIMIDINE; GASTRIC CANCERS; GENOME-WIDE ASSOCIATION STUDIES; KNOWLEDGE-BASED ALGORITHMS; MULTIPLE REGRESSION MODEL; MULTIPLE TESTING PROBLEMS; SINGLE NUCLEOTIDE POLYMORPHISMS;

ALGORITHMS; BIOINFORMATICS; CHEMOTHERAPY; DIAGNOSIS; DISEASES; KNOWLEDGE BASED SYSTEMS; PATIENT MONITORING; REGRESSION ANALYSIS;

GENES;

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE; FLUOROURACIL; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; HEMOGLOBIN; IRINOTECAN; METHOTREXATE; PACLITAXEL;

ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SCREENING; CANCER SURGERY; COLON CANCER; CREATININE BLOOD LEVEL; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC ALGORITHM; GENETIC ASSOCIATION; GENOTYPE; HUMAN; KNOWLEDGE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; PHARMACOGENOMICS; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER;

BIOINFORMATICS; FLUOROPYRIMIDINE; GASTRIC CANCER; GENOME-WIDE ASSOCIATION STUDY; SINGLE-NUCLEOTIDE POLYMORPHISMS;

ALGORITHMS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLONIC NEOPLASMS; COMPUTATIONAL BIOLOGY; FEMALE; FLUOROURACIL; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMANS; MALE; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, EPIDERMAL GROWTH FACTOR; REGRESSION ANALYSIS; STOMACH NEOPLASMS;

EID: 84886421287     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2013.05.021     Document Type: Article

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