Role of ADAMTS13 in the management of thrombotic microangiopathies including thrombotic thrombocytopenic purpura (TTP)

British Journal of Haematology

Volumn 163, Issue 4, 2013, Pages 514-519

  Shah, Neil ^a   Rutherford, Cynthia ^b   Matevosyan, Karen ^a   Shen, Yu Min ^b   Sarode, Ravi ^a  

^a Department of Pathology   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

ADAMTS13; Atypical haemolytic uremic syndrome; Plasma exchange; Thrombotic microangiopathy; Thrombotic thrombocytopenic purpura

Indexed keywords

D DIMER; ECULIZUMAB; HAPTOGLOBIN; LACTATE DEHYDROGENASE; PREDNISONE; RITUXIMAB; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; HEMOLYSIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTERNATIONAL NORMALIZED RATIO; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PLASMAPHERESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTHROMBIN TIME; RELAPSE; RETROSPECTIVE STUDY; SCHOOL CHILD; THROMBOCYTE COUNT; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT RESPONSE;

ADAMTS13; ATYPICAL HAEMOLYTIC UREMIC SYNDROME; PLASMA EXCHANGE; THROMBOTIC MICROANGIOPATHY; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ADAM PROTEINS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; CHILD; DIAGNOSIS, DIFFERENTIAL; DISEASE MANAGEMENT; FEMALE; HUMANS; MALE; METALLOENDOPEPTIDASES; MIDDLE AGED; PLASMA EXCHANGE; PURPURA, THROMBOTIC THROMBOCYTOPENIC; RETROSPECTIVE STUDIES; THROMBOTIC MICROANGIOPATHIES; YOUNG ADULT;

EID: 84886405720     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12569     Document Type: Article

References (32)

1. Amorosi, E.L. & Ultmann, J.E. (1966) Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature. Medicine, 45, 139-159.
2. Benz, K. & Amann, K. (2010) Thrombotic microangiopathy: new insights. Current opinion in nephrology and hypertension, 19, 242-247.
3. Bianchi, V., Robles, R., Alberio, L., Furlan, M. & Lammle, B. (2002) Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders: a severely deficient activity is specific for thrombotic thrombocytopenic purpura. Blood, 100, 710-713.
4. Bohm, M., Gerlach, R., Beecken, W.D., Scheuer, T., Stier-Bruck, I. & Scharrer, I. (2003) ADAMTS-13 activity in patients with brain and prostate tumors is mildly reduced, but not correlated to stage of malignancy and metastasis. Thrombosis Research, 111, 33-37.
5. Cataland, S.R., Yang, S. & Wu, H.M. (2012) The use of ADAMTS13 activity, platelet count, and serum creatinine to differentiate acquired thrombotic thrombocytopenic purpura from other thrombotic microangiopathies. British journal of haematology, 157, 501-503.
6. Fujikawa, K., Suzuki, H., McMullen, B. & Chung, D. (2001) Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family. Blood, 98, 1662-1666.
7. Furlan, M., Robles, R., Galbusera, M., Remuzzi, G., Kyrle, P.A., Brenner, B., Krause, M., Scharrer, I., Aumann, V., Mittler, U., Solenthaler, M. & Lammle, B. (1998) von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. The New England journal of medicine, 339, 1578-1584.
8. Hovinga, J.A.K., Vesely, S.K., Terrell, D.R., Lammle, B. & George, J.N. (2009) Survival and relapse in patients with thrombotic thrombocytopenic purpura. Blood, 115, 1500-1511.
9. Kokame, K., Nobe, Y., Kokubo, Y., Okayama, A. & Miyata, T. (2005) FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay. British journal of haematology, 129, 93-100.
10. Kremer-Hovinga, J.A., Studt, J.-D., Alberio, L. & Lämmle, B. (2004) Von Willebrand factor-cleaving protease (ADAMTS-13) activity determination in the diagnosis of thrombotic microangiopathies: the Swiss experience. Seminars in Hematology, 41, 75-82.
11. Lattuada, A., Rossi, E., Calzarossa, C., Candolfi, R. & Mannucci, P.M. (2003) Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome. Haematologica, 88, 1029-1034.
12. Levy, G.G., Nichols, W.C., Lian, E.C., Foroud, T., McClintick, J.N., McGee, B.M., Yang, A.Y., Siemieniak, D.R., Stark, K.R., Gruppo, R., Sarode, R., Shurin, S.B., Chandrasekaran, V., Stabler, S.P., Sabio, H., Bouhassira, E.E., Upshaw, J.D. Jr, Ginsburg, D. & Tsai, H.M. (2001) Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature, 413, 488-494.
13. Mannucci, P.M., Karimi, M., Mosalaei, A., Canciani, M.T. & Peyvandi, F. (2003) Patients with localized and disseminated tumors have reduced but measurable levels of ADAMTS-13 (von Willebrand factor cleaving protease). Haematologica, 88, 454-458.
14. Moake, J.L. (2002) Thrombotic microangiopathies. The New England journal of medicine, 347, 589-600.
15. Mori, Y., Wada, H., Gabazza, E.C., Minami, N., Nobori, T., Shiku, H., Yagi, H., Ishizashi, H., Matsumoto, M. & Fujimura, Y. (2002) Predicting response to plasma exchange in patients with thrombotic thrombocytopenic purpura with measurement of vWF-cleaving protease activity. Transfusion, 42, 572-580.
16. Moschcowitz, E. (1924) Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease. Proceeding of the New York Pathology Society, 24, 21-24.
17. Nguyen, T.C., Liu, A., Liu, L., Ball, C., Choi, H., May, W.S., Aboulfatova, K., Bergeron, A.L. & Dong, J.F. (2007) Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis. Haematologica, 92, 121-124.
18. Ono, T., Mimuro, J., Madoiwa, S., Soejima, K., Kashiwakura, Y., Ishiwata, A., Takano, K., Ohmori, T. & Sakata, Y. (2006) Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. Blood, 107, 528-534.
19. Peyvandi, F., Ferrari, S., Lavoretano, S., Canciani, M.T. & Mannucci, P.M. (2004) von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura. British journal of haematology, 127, 433-439.
20. Raife, T., Atkinson, B., Montgomery, R., Vesely, S. & Friedman, K. (2004) Severe deficiency of VWF-cleaving protease (ADAMTS13) activity defines a distinct population of thrombotic microangiopathy patients. Transfusion, 44, 146-150.
21. Remuzzi, G., Galbusera, M., Noris, M., Canciani, M.T., Daina, E., Bresin, E., Contaretti, S., Caprioli, J., Gamba, S., Ruggenenti, P., Perico, N., Mannucci, P.M. & Registry Italian of Recurrent and Familial HUS/TTP. Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. (2002) von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Blood, 100, 778-785.
22. Rock, G.A., Shumak, K.H., Buskard, N.A., Blanchette, V.S., Kelton, J.G., Nair, R.C. & Spasoff, R.A. (1991) Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. The New England journal of medicine, 325, 393-397.
23. Scully, M., Yarranton, H., Liesner, R., Cavenagh, J., Hunt, B., Benjamin, S., Bevan, D., Mackie, I. & Machin, S. (2008) Regional UK TTP Registry: correlation with laboratory ADAMTS 13 analysis and clinical features. British Journal of Haematology, 142, 819-826.
24. Tripodi, A., Chantarangkul, V., Bohm, M., Budde, U., Dong, J.F., Friedman, K.D., Galbusera, M., Girma, J.P., Moake, J., Rick, M.E., Studt, J.D., Turecek, P.L. & Mannucci, P.M. (2004) Measurement of von Willebrand factor cleaving protease (ADAMTS-13): results of an international collaborative study involving 11 methods testing the same set of coded plasmas. Journal of thrombosis and haemostasis: JTH, 2, 1601-1609.
25. Tripodi, A., Peyvandi, F., Chantarangkul, V., Palla, R., Afrasiabi, A., Canciani, M.T., Chung, D.W., Ferrari, S., Fujimura, Y., Karimi, M., Kokame, K., Kremer Hovinga, J.A., Lammle, B., de Meyer, S.F., Plaimauer, B., Vanhoorelbeke, K., Varadi, K. & Mannucci, P.M. (2008) Second international collaborative study evaluating performance characteristics of methods measuring the von Willebrand factor cleaving protease (ADAMTS-13). Journal of thrombosis and haemostasis: JTH, 6, 1534-1541.
26. Tsai, H.M. (2010) Pathophysiology of thrombotic thrombocytopenic purpura. International journal of hematology, 91, 1-19.
27. Tsai, H.M. (2013) Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. The American journal of medicine, 126, 200-209.
28. Tsai, H.M. & Lian, E.C. (1998) Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. The New England journal of medicine, 339, 1585-1594.
29. Vesely, S.K., George, J.N., Lämmle, B., Studt, J.D., Alberio, L., El-Harake, M.A. & Raskob, G.E. (2003) ADAMTS13 activity in thrombotic thrombocytopenc purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. Blood, 102, 60-68.
30. Veyradier, A., Obert, B., Houllier, A., Meyer, D. & Girma, J.P. (2001) Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: a study of 111 cases. Blood, 98, 1765-1772.
31. Zheng, X., Chung, D., Takayama, T.K., Majerus, E.M., Sadler, J.E. & Fujikawa, K. (2001) Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. Journal of Biological Chemistry, 276, 41059-41063.
32. Zheng, X.L., Kaufman, R.M., Goodnough, L.T. & Sadler, J.E. (2004) Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura. Blood, 103, 4043-4049.