Lineage Specifiers: New Players in the Induction of Pluripotency

Genomics, Proteomics and Bioinformatics

Volumn 11, Issue 5, 2013, Pages 259-263

  Shu, Jian ^a,b   Deng, Hongkui ^a,b  

^a Peking University   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Cell fate conversion; IPSCs; Lineage specifier; Pluripotency; Reprogramming; Seesaw model

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2;

CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; EMBRYONIC STEM CELL; FIBROBLAST; GENE EXPRESSION REGULATION; GENE INDUCTION; GERM LAYER; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; REGULATORY MECHANISM; REVIEW; SOMATIC CELL;

CELL FATE CONVERSION; IPSCS; LINEAGE SPECIFIER; PLURIPOTENCY; REPROGRAMMING; SEESAW MODEL;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELL NUCLEUS; EMBRYONIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS;

EID: 84886403062     PISSN: 16720229     EISSN: 22103244     Source Type: Journal    
DOI: 10.1016/j.gpb.2013.09.005     Document Type: Review

References (30)

1. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
2. Robinton D.A., Daley G.Q. The promise of induced pluripotent stem cells in research and therapy. Nature 2012, 481:295-305.
3. Wilmut I., Schnieke A.E., McWhir J., Kind A.J., Campbell K.H.S. Viable offspring derived from fetal and adult mammalian cells. Nature 1997, 385:810-813.
4. Cowan C.A., Atienza J., Melton D.A., Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 2005, 309:1369-1373.
5. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
6. Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920.
7. Heng J.C., Feng B., Han J., Jiang J., Kraus P., Ng J.H., et al. The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 2010, 6:167-174.
8. Feng B., Jiang J., Kraus P., Ng J.H., Heng J.C., Chan Y.S., et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol 2009, 11:197-203.
9. Chia N.Y., Chan Y.S., Feng B., Lu X., Orlov Y.L., Moreau D., et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 2010, 468:316-320.
10. Buganim Y., Faddah D.A., Cheng A.W., Itskovich E., Markoulaki S., Ganz K., et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 2012, 150:1209-1222.
11. Maekawa M., Yamaguchi K., Nakamura T., Shibukawa R., Kodanaka I., Ichisaka T., et al. Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature 2011, 474:225-229.
12. Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122:947-956.
13. Young R.A. Control of the embryonic stem cell state. Cell 2011, 144:940-954.
14. Loh K.M., Lim B. A precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell 2011, 8:363-369.
15. Niwa H., Miyazaki J., Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000, 24:372-376.
16. Thomson M., Liu S.J., Zou L.N., Smith Z., Meissner A., Ramanathan S. Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell 2011, 145:875-889.
17. Wang Z., Oron E., Nelson B., Razis S., Ivanova N. Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 2012, 10:440-454.
18. Shu J., Wu C., Wu Y., Li Z., Shao S., Zhao W., et al. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 2013, 153:963-975.
19. Yang P., Wang Y., Chen J., Li H., Kang L., Zhang Y., et al. RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency. Stem Cells 2011, 29:791-801.
20. Nakagawa M., Koyanagi M., Tanabe K., Takahashi K., Ichisaka T., Aoi T., et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 2007, 26:101-106.
21. Montserrat N., Nivet E., Sancho-Martinez I., Hishida T., Kumar S., Miquel L., et al. Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Cell Stem Cell 2013, 13:341-350.
22. Huang S. Reprogramming cell fates: reconciling rarity with robustness. Bioessays 2009, 31:546-560.
23. Davis R.L., Weintraub H., Lassar A.B. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 1987, 51:987-1000.
24. Vierbuchen T., Ostermeier A., Pang Z.P., Kokubu Y., Südhof T.C., Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010, 463:1035-1041.
25. Ieda M., Fu J.D., Delgado-Olguin P., Vedantham V., Hayashi Y., Bruneau B.G., et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010, 142:375-386.
26. Vierbuchen T., Wernig M. Direct lineage conversions: unnatural but useful?. Nat Biotechnol 2011, 29:892-907.
27. Szabo E., Rampalli S., Risueño R.M., Schnerch A., Mitchell R., Fiebig-Comyn A., et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 2010, 468:521-526.
28. Han D.W., Tapia N., Hermann A., Hemmer K., Höing S., Araúzo-Bravo M.J., et al. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 2012, 10:465-472.
29. Ring K.L., Tong L.M., Balestra M.E., Javier R., Andrews-Zwilling Y., Li G., et al. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell 2012, 11:100-109.
30. Thier M., Wörsdörfer P., Lakes Y.B., Gorris R., Herms S., Opitz T., et al. Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 2012, 10:473-479.