Investigation of MTHFR C677T gene polymorphism, biochemical and clinical parameters in turkish migraine patients: Association with allodynia and fatigue

Cellular and Molecular Neurobiology

Volumn 33, Issue 8, 2013, Pages 1055-1063

  Bahadir, Anzel ^a   Eroz, Recep ^a   Dikici, Suber ^a  

^a DUZCE UNIVERSITY   (Turkey)

Author keywords

Biochemical and clinical parameters; Migraine; MTHFR C677T polymorphism

Indexed keywords

CHOLESTEROL; FOLIC ACID; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ALLODYNIA; AMINO ACID BLOOD LEVEL; ARTICLE; BIOCHEMISTRY; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FATIGUE; FEMALE; FOLIC ACID BLOOD LEVEL; GENDER; GENE; GENETIC VARIABILITY; HUMAN; INSOMNIA; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; MTHFR GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; TURKEY (REPUBLIC);

ADULT; ALLELES; CASE-CONTROL STUDIES; ELECTROPHORESIS, AGAR GEL; FATIGUE; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERALGESIA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIGRAINE DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; TURKEY;

EID: 84886391178     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-013-9972-1     Document Type: Article

References (46)

1. Bigal ME, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545-550
2. Colson NJ, Lea RA, Sharon Q, Griffiths LR (2006) The role of vascular and hormonal genes in migraine susceptibility. Mol Genet Metab 88:107-113
3. Das UN (2003) Folic acid says NO to vascular diseases. Nutrition 19:686-692
4. Ducros A, Tournier-Lasserve E, Bousser MG (2002) The genetics of migraine. Lancet Neurol 1:285-293
5. Edvinsson L, Uddman R (2005) Neurobiology in primary headaches. Brain Res Brain Res Rev 48:438-456
6. Evers S, Koch HG, Hustedt IW (1997) Plasma homocysteine levels in primary headache. In: Olesen J, Edvinsson L (eds) Headache pathogenesis monoamines, neuropeptides, purines, and nitrix oxide. Lippincott-Raven, Philadelphia, pp 215-218
7. Ferraris E, Marzocchi N, Brovia D, Castellana CN, Pini LA (2003) Homocysteine levels and cardiovascular disease in migraine with aura. J Headache Pain 4:62-66
8. Ferro A, Castro MJ, Lemos C, Santos M, Sousa A, Pereira-Monteiro J, Sequeiros J, Maciel P (2008) The C677T polymorphism in MTHFR is not associated with migraine in Portugal. Dis Markers 25:107-113
9. Ford ES, Li C, Pearson WS, Zhao G, Strine TW, Mokdad AH (2008) Body mass index and headaches: findings from a national sample of US adults. Cephalalgia 28:1270-1276
10. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113
11. Gavgani SC, Hoseinian MM (2012) Comparative study on homocysteine levels in migraine patients and normal peoples. Ann Bio Res 3:1804-1807
12. Headache classification committee of the International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 8(Suppl.7):1-96
13. Hering-Hanit R, Gadoth N, Yavetz A, Gavendo S, Sela B (2001) Is blood homocysteine elevated in migraine? Headache 41:779-781
14. Joshi G, Pradhan S, Mittal B (2009) Role of the ACE ID and MTHFR C677T polymorphisms in genetic susceptibility of migraine in a north Indian population. J Neurol Sci 277:133-137
15. Kara I, Sazci A, Ergul E, Kaya G, Kilic G (2003) Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 111:84-90
16. Kaunisto MA, Kallela M, Hamalainen E, Kilpikari R, Havanka H, Harno H, Nissila M, Sakö E, Ilmavirta M, Liukkonen J, Teirmaa H, Törnwall O, Jussila M, Terwilliger J, Farkkila M, Kaprio J, Palotie A, Wessman M (2006) Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura. Cephalalgia 26:1462-1472
17. Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K (2000) The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine. Am J Med Genet 96:762-764
18. Lea RA, Ovcaric M, Sundholm J, MacMillan J, Griffiths LR (2004) The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura. BMC Med 2:3
19. Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, Heistad DD (1996) Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest 98:24-29
20. Lipton RB, Bigal ME (2005) The epidemiology of migraine. Am J Med 118:3S-10S
21. Liu A, Menon S, Colson NJ, Quinlan S, Cox H, Peterson M, Tiang T, Haupt LM, Lea RA, Griffiths LR (2010) Analysis of the MTHFR C677T variant with migraine phenotypes. BMC Res Notes 3:21
22. Lovati C, D'Amico D, Rosa S, Suardelli M, Mailland E, Bertora P, Pomati S, Mariani C, Bussone G (2007) Allodynia in different forms of migraine. Neurol Sci 28:S220-S221
23. Moschiano F, D'Amico D, Usai S, Grazzi L, Di Stefano M, Ciusani E, Erba N, Bussone G (2008) Homocysteine plasma levels in patients with migraine with aura. Neurol Sci 29:S173-S175
24. Mulder EJ, Van Baal C, Gaist D, Kallela M, Kaprio J, Svensson DA, Nyholt DR, Martin NG, MacGregor AJ, Cherkas LF, Boomsma DI, Palotie A (2003) Genetic and environmental influences on migraine: a twin study across six countries. Twin Res 6:422-431
25. Oterino A, Valle N, Bravo Y, Muñoz P, Sánchez-Velasco P, Ruiz-Alegría C, Castillo J, Leyva-Cobián F, Vadillo A, Pascual J (2004) MTHFR T677 homozygosis influences the presence of aura in migraineurs. Cephalalgia 24:491-494
26. Oterino A, Valle N, Pascual J, Bravo Y, Muñoz P, Castillo J, Ruiz-Alegría C, Sánchez-Velasco P, Leyva-Cobián F, Cid C (2005) Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele. Brain Res Mol Brain Res 139:163-168
27. Oterino A, Pascual J, Ruiz de Alegria C, Valle N, Castillo J, Bravo Y, González F, Sánchez-Velasco P, Cayón A, Leyva-Cobián F, Alonso-Arranz A, Muñoz P (2006) Association of migraine and ESR1 G325C polymorphism. Neuroreport 17:61-64
28. Oterino A, Toriello M, Valle N, Castillo J, Alonso-Aranz A, Bravo Y, Ruiz-Alegria C, Quintela E, Pascual J (2010) The relationship between homocysteine and genes of folate-related enzymes in migraine patients. Headache 50:99-108
29. Parsons AA, Strijbos PJ (2003) The neuronal versus vascular hypothesis of migraine and cortical spreading depression. Curr Opin Pharmacol 3:73-77
30. Peterlin BL, Rapoport AM, Kurth T (2010) Migraine and obesity: epidemiology, mechanisms, and Implications. Headache 50:631-648
31. Rubino E, Ferrero M, Rainero I, Binello E, Vaula G, Pinessi L (2009) Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis. Cephalalgia 29:818-825
32. Russell MB, Olesen J (1993) The genetics of migraine without aura and migraine with aura. Cephalalgia 13:245-248
33. Sazci A, Ergul E, Kaya G, Kara I (2005) Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey. Cell Biochem Funct 23:51-54
34. Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, Frants RR, van den Maagdenberg AM, van Buchem M, Ferrari MD, Launer LJ (2006) Migraine and MTHFR C677T genotype in a population based sample. Ann Neurol 59:372-375
35. Schürks M, Zee RY, Buring JE, Kurth T (2008) Interrelationships among the MTHFR 677C > T polymorphism, migraine, and cardiovascular disease. Neurology 71:505-513
36. Schürks M, Zee RYL, Buring JE, Kurth T (2010) MTHFR 677C- > T and ACE D/I polymorphisms and migraine attack frequency in women. Cephalalgia 30:447-456
37. Seidel S, Hartl T, Weber M, Matterey S, Paul A, Riederer F, Gharabaghi M, Wöber-Bingöl C, Wöber C, PAMINA study group (2009) Quality of sleep, fatigue and daytime sleepiness in migraine - a controlled study. Cephalalgia 29:662-669
38. Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr 19:217-246
39. Shyti R, de Vries B, van den Maagdenberg A (2011) Migraine genes and the relation to gender. Headache 51:880-890
40. Stewart WF, StaVa J, Lipton RB, Ottman R (1997) Familial risk of migraine: a population-based study. Ann Neurol 41:166-172
41. Stuart S, Cox HC, Lea RA, Griffiths LR (2012) The role of the MTHFR gene in migraine. Headache 52:515-519
42. Tietjen GE, Herial NA, Utley C, White L, Yerga-Woolwine S, Joe B (2009) Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine. Cephalalgia 29:960-968
43. Todt U, Freudenberg J, Goebel I, Netzer C, Heinze A, Heinze-Kuhn K, Göbel H, Kubisch C (2006) MTHFR C677T polymorphism and migraine with aura. Ann Neurol 60:621-623
44. Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325:1202
45. Wewers ME, Lowe NK (1990) A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health 13:227-236
46. Winter AC, Berger K, Buring JE, Kurth T (2009) Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia 29:269-278