Effect of bone marrow derived mesenchymal stem cells on healing of induced full-thickness skin wounds in albino rat

International Journal of Stem Cells

Volumn 6, Issue 1, 2013, Pages 12-25

  Basiouny, Hend Shafik ^a   Salama, Nagla Mohamed ^a   El Maadawi, Zeinab Mohamed ^a   Farag, Eman Abas ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

BMSCs; PKH26; Skin; VEGF; Wound healing

Indexed keywords

RATTUS;

EID: 84886306050     PISSN: 20053606     EISSN: 20055447     Source Type: Journal    
DOI: 10.15283/ijsc.2013.6.1.12     Document Type: Article

References (40)

1. Hocking AM, Gibran NS. Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair. Exp Cell Res 2010;316:2213-2219
2. Wu Y, Huang S, Enhe J, Fu X. Insights into bone marrow- derived mesenchymal stem cells safety for cutaneous repair and regeneration. Int Wound J 2012;9:586-594
3. Tark KC, Hong JW, Kim YS, Hahn SB, Lee WJ, Lew DH. Effects of human cord blood mesenchymal stem cells on cutaneous wound healing in leprdb mice. Ann Plast Surg 2010;65:565-572
4. Alhadlaq A, Mao JJ. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 2004;13:436-448
5. Rochefort GY, Vaudin P, Bonnet N, Pages JC, Domenech J, Charbord P, Eder V. Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies? Respir Res 2005;6:125
6. Ode A, Kopf J, Kurtz A, Schmidt-Bleek K, Schrade P, Kolar P, Buttgereit F, Lehmann K, Hutmacher DW, Duda GN, Kasper G. CD73 and CD29 concurrently mediate the mechanically induced decrease of migratory capacity of mesenchymal stromal cells. Eur Cell Mater 2011;22:26-42
7. Wallace PK, Muirhead KA. Cell tracking 2007: a proliferation of probes and applications. Immunol Invest 2007;36: 527-561
8. Borena BM, Pawde AM, Amarpal, Aithal HP, Kinjavdekar P, Singh R, Kumar D. Evaluation of autologous bone marrow- derived nucleated cells for healing of full-thickness skin wounds in rabbits. Int Wound J 2010;7:249-260
9. Bohling MW, Henderson RA, Swaim SF, Kincaid SA, Wright JC. Cutaneous wound healing in the cat: a macroscopic description and comparison with cutaneous wound healing in the dog. Vet Surg 2004;33:579-587
10. Chen L, Tredget EE, Wu PY, Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008;3:e1886
11. Zhang J, Zhi W, Tan M, Chen X, Li X, Deng L. An experimental study on rabbit bone marrow mesenchymal stem cells double-labeled by PKH26 and 5-bromo-2'-deoxyuridine in vitro and application in cardiac patch. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2010;24:828-833
12. Kiernan JA. Histological and histochemical methods: theory and practice. 3rd ed. London, New York &New Delhi: Arnold publisher; 2001. 111-162
13. Culling CFA. Handbook of histopathological and histochemical techniques. 3rd ed. London and Boston: Butterworths and Co. Ltd; 1975. 414-525
14. Bancroft JD, Gamble M. Connective tissue stains. In: Bancroft JD, Gamble M, eds. Theory and practice of histological techniques. Edinburgh, London, Oxford, New York, Philadelphia, St Louis, Sydney and Toronto: Elsevier Health Sciences, Churchill Livingstone; 2008. 150-225
15. Emsley R, Dunn G, White IR. Mediation and moderation of treatment effects in randomised controlled trials of complex interventions. Stat Methods Med Res 2010;19:237-270
16. Augello A, Kurth TB, De Bari C. Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches. Eur Cell Mater 2010;20:121-133
17. Nishino Y, Ebisawa K, Yamada Y, Okabe K, Kamei Y, Ueda M. Human deciduous teeth dental pulp cells with basic fibroblast growth factor enhance wound healing of skin defect. J Craniofac Surg 2011;22:438-442
18. Givan AL, Fisher JL, Waugh MG, Bercovici N, Wallace PK. Use of cell-tracking dyes to determine proliferation precursor frequencies of antigen-specific T cells. Methods Mol Biol 2004;263:109-124
19. Kawaguchi K, Katsuyama Y, Kikkawa S, Setsu T, Terashima T. PKH26 is an excellent retrograde and anterograde fluorescent tracer characterized by a small injection site and strong fluorescence emission. Arch Histol Cytol 2010;73:65-72
20. Tario JD Jr, Muirhead KA, Pan D, Munson ME, Wallace PK. Tracking immune cell proliferation and cytotoxic potential using flow cytometry. Methods Mol Biol 2011;699: 119-164
21. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007;25:2648-2659
22. Seifert AW, Monaghan JR, Voss SR, Maden M. Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates. PLoS One 2012;7:e32875
23. Krafts KP. Tissue repair: The hidden drama. Organogenesis 2010;6:225-233
24. Akela A, Nandi SK, Banerjee D, Das P, Roy S, Joardar SN, Mandal M, Das PK, Pradhan NR. Evaluation of autologous bone marrow in wound healing in animal model: a possible application of autologous stem cells. Int Wound J 2012;9: 505-516
25. McFarlin K, Gao X, Liu YB, Dulchavsky DS, Kwon D, Arbab AS, Bansal M, Li Y, Chopp M, Dulchavsky SA, Gautam SC. Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat. Wound Repair Regen 2006;14:471-478
26. Isackson D, Cook KJ, McGill LD, Bachus KN. Mesenchymal stem cells increase collagen infiltration and improve wound healing response to porous titanium percutaneous implants. Med Eng Phys 2012. [Epub ahead of print]
27. Maiborodin IV, Yakimova NV, Matveyeva VA, Pekarev OG, Maiborodina EI, Pekareva EO. Angiogenesis in rat uterine cicatrix after injection of autologous bone marrow mesenchymal stem cells. Bull Exp Biol Med 2011;150:756-761
28. Sasaki M, Abe R, Fujita Y, Ando S, Inokuma D, Shimizu H. Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 2008;180:2581-2587
29. Li C, Zheng Y, Wang X, Xia W, Gao H, Li D, Ma X. Bone marrow-derived stem cells contribute skin regeneration in skin and soft tissue expansion. J Cell Physiol 2011;226:2834-2840
30. Schlosser S, Dennler C, Schweizer R, Eberli D, Stein JV, Enzmann V, Giovanoli P, Erni D, Plock JA. Paracrine effects of mesenchymal stem cells enhance vascular regeneration in ischemic murine skin. Microvasc Res 2012;83: 267-275
31. Chen L, Tredget EE, Wu PY, Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008;3:e1886
32. Badiavas EV, Abedi M, Butmarc J, Falanga V, Quesenberry P. Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol 2003;196:245-250
33. Sköld MK, von Gertten C, Sandberg-Nordqvist AC, Mathiesen T, Holmin S. VEGF and VEGF receptor expression after experimental brain contusion in rat. J Neurotrauma 2005;22:353-367
34. Nogami M, Hoshi T, Kinoshita M, Arai T, Takama M, Takahashi I. Vascular endothelial growth factor expression in rat skin incision wound. Med Mol Morphol 2007;40:82-87
35. Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H. The role of vascular endothelial growth factor in wound healing. J Surg Res 2009;153:347-358
36. Numata Y, Terui T, Okuyama R, Hirasawa N, Sugiura Y, Miyoshi I, Watanabe T, Kuramasu A, Tagami H, Ohtsu H. The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor. J Invest Dermatol 2006;126:1403-1409
37. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007;127:514-525
38. Fossum TW, Hedlund CS, Johnson A., Schulz KS, Seim HB, Willard MD, Baer A, Carroll GL. Manual of small animal surgery. 3rd ed. St. Louis, Missouri: Elsevier/Mosby; 2007. 159-259
39. Kwon H, Liu PH, Lew DH, Nishimura E, Orgill DP. Hair follicle melanocyte cells as a renewable source of melanocytes for culture and transplantation. Eplasty 2008;8:e7
40. Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 2009;4:206-216