The authors reply

New England Journal of Medicine

Volumn 369, Issue 17, 2013, Pages 1661-

  Doody, Rachelle S ^a   Aisen, Paul S ^b   Iwatsubo, Takeshi ^c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; SEMAGACESTAT; ALANINE; AZEPINE DERIVATIVE; DRUG DERIVATIVE; SECRETASE;

ATTRIBUTABLE RISK; CENTRAL NERVOUS SYSTEM DISEASE; HUMAN; LETTER; MOLECULAR MECHANICS; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SYNTHESIS INHIBITION; ALZHEIMER DISEASE; DRUG ANTAGONISM; FEMALE; MALE; NOTE;

ALANINE; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; AZEPINES; FEMALE; HUMANS; MALE;

EID: 84886296266     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1310845     Document Type: Letter

References (7)

1. RS Doody R Raman M Farlow A phase 3 trial of semagacestat for treatment of Alzheimer's disease N Engl J Med 369 2013 341 350
2. ME Fortini Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling Nat Rev Mol Cell Biol 3 2002 673 684
3. S Zhang CC Wu JF Fecteau Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44 Proc Natl Acad Sci U S A 110 2013 6127 6132
4. J Settleman A therapeutic opportunity in melanoma: ErbB4 makes a mark on skin Cancer Cell 16 2009 278 279
5. F van Roy G Berx The cell-cell adhesion molecule E-cadherin Cell Mol Life Sci 65 2008 3756 3788
6. JR Cirrito PC May MA O'Dell In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life J Neurosci 23 2003 8844 8853
7. S Hong O Quintero-Monzon BL Ostaszewski Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation J Neurosci 31 2011 15861 15869