Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization

Journal of Clinical Virology

Volumn 58, Issue 3, 2013, Pages 584-586

  Grassi, Maria Fernanda Rios ^a,b   Olavarria, Viviana Nilla ^b   Kruschewsky, Ramon de Almeida ^b   Yamano, Yoshihisa ^c   Jacobson, Steven ^d   Taylor, Graham P ^e   Martin, Fabiola ^f   Galvão Castro, Bernardo ^a,b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA   (Brazil)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Cut off value; Diagnosis; HAM TSP; HTLV 1; Proviral load

Indexed keywords

ASYMPTOMATIC INFECTION; BLOOD ANALYSIS; CEREBROSPINAL FLUID; DERMATITIS; DIAGNOSTIC PROCEDURE; DISEASE CLASSIFICATION; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; INFLAMMATORY DISEASE; KERATOCONJUNCTIVITIS SICCA; LIMIT OF QUANTITATION; NEUROIMAGING; NEUROLOGIC DISEASE; NONHUMAN; NOTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROVIRUS; SENSITIVITY AND SPECIFICITY; STANDARDIZATION; TROPICAL SPASTIC PARAPARESIS; VIRUS ISOLATION; VIRUS LOAD; WORLD HEALTH ORGANIZATION;

CUT-OFF VALUE; DIAGNOSIS; HAM/TSP; HTLV; HTLV-1; HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS; HUMAN T-CELL LYMPHOTROPIC VIRUS; PBMC; PERIPHERAL BLOOD MONONUCLEAR CELLS; PROVIRAL LOAD; PVL;

HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; PARAPARESIS, TROPICAL SPASTIC; PROVIRUSES; VIRAL LOAD;

EID: 84886295576     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2013.09.003     Document Type: Note

References (17)

1. Hlela C., Shepperd S., Khumalo N.P., Taylor G.P. The prevalence of human T-cell lymphotropic virus type 1 in the general population is unknown. AIDS Rev 2009, 11(4):205-214.
2. WHO Report on HTLV-1 Infection and Associated Diseases 1989, World Health Organization Scientific Group, Kagoshima.
3. Demontis M.A., Hilburn S., Taylor G.P., Human T. Cell lymphotropic virus type 1 viral load variability and long-term trends in asymptomatic carriers and in patients with human T cell lymphotropic virus type 1-related diseases. AIDS Res Hum Retroviruses 2013, 29(2):359-364.
4. De Castro-Costa C.M., Araujo A.Q., Barreto M.M., et al. Proposal for diagnostic criteria of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). AIDS Res Hum Retroviruses 2006, 22(10):931-935.
5. Best I., Adaui V., Verdonck K., et al. Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. Clin Exp Immunol 2006, 146(2):226-233.
6. Lezin A., Olindo S., Oliere S., et al. Human T lymphotropic virus type I (HTLV-I) proviral load in cerebrospinal fluid: a new criterion for the diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis?. J Infect Dis 2005, 191(11):1830-1834.
7. Manns A., Miley W.J., Wilks R.J., et al. Quantitative proviral DNA and antibody levels in the natural history of HTLV-I infection. J Infect Dis 1999, 180(5):1487-1493.
8. Nagai M., Usuku K., Matsumoto W., et al. Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J Neurovirol 1998, 4(6):586-593.
9. Olindo S., Lezin A., Cabre P., et al. HTLV-1 proviral load in peripheral blood mononuclear cells quantified in 100 HAM/TSP patients: a marker of disease progression. J Neurol Sci 2005, 237(1/2):53-59.
10. Montanheiro P., Oliveira A., Posada-Vergara M., et al. Human T-cell lymphotropic virus type I (HTLV-I) proviral DNA viral load among asymptomatic patients and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. Braz J Med Biol Res 2005, 38(11):1643-1647.
11. Silva M.T., Harab R.C., Leite A.C., Schor D., Araujo A., Andrada-Serpa M.J. Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. Clin Infect Dis 2007, 44(5):689-692.
12. Primo J., Siqueira I., Nascimento M.C., et al. High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. Braz J Med Biol Res 2009, 42(8):761-764.
13. Castro-Lima Vargens C., Grassi M.F., Boa-Sorte N., et al. Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load. J Clin Virol 2011, 52(3):177-180.
14. Grassi M.F., Olavarria V.N., Kruschewsky Rde A., et al. Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP. J Med Virol 2011, 83(7):1269-1274.
15. Furtado Mdos S., Andrade R.G., Romanelli L.C., et al. Monitoring the HTLV-1 proviral load in the peripheral blood of asymptomatic carriers and patients with HTLV-associated myelopathy/tropical spastic paraparesis from a Brazilian cohort: ROC curve analysis to establish the threshold for risk disease. J Med Virol 2012, 84(4):664-671.
16. Pang X.L., Fox J.D., Fenton J.M., Miller G.G., Caliendo A.M., Preiksaitis J.K. Interlaboratory comparison of cytomegalovirus viral load assays. Am J Transplant 2009, 9(2):258-268.
17. Preiksaitis J.K., Pang X.L., Fox J.D., Fenton J.M., Caliendo A.M., Miller G.G. Interlaboratory comparison of epstein-barr virus viral load assays. Am J Transplant 2009, 9(2):269-279.