Human T cell lymphotropic virus type 1 viral load variability and long-term trends in asymptomatic carriers and in patients with human T cell lymphotropic virus type 1-related diseases

AIDS Research and Human Retroviruses

Volumn 29, Issue 2, 2013, Pages 359-364

  Demontis, Maria A ^a   Hilburn, Silva ^a   Taylor, Graham P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; HUMAN TISSUE; LYMPH NODE BIOPSY; MAJOR CLINICAL STUDY; MALE; NORMAL VALUE; PATIENT MONITORING; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROVIRAL LOAD; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; T CELL LEUKEMIA; TROPICAL SPASTIC PARAPARESIS; VIRUS LOAD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASYMPTOMATIC DISEASES; CARRIER STATE; CEREBROSPINAL FLUID; CHILD; CHILD, PRESCHOOL; FEMALE; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MALE; MIDDLE AGED; VIRAL LOAD; YOUNG ADULT;

EID: 84872914575     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2012.0132     Document Type: Article

References (34)

1. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, and Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980;77(12):7415-7419. (Pubitemid 11131140)
2. Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, and Miyoshi I: Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981;78(10):6476-6480. (Pubitemid 12179735)
3. Gessain A, Barin F, Vernant J, Gout O, Maurs L, Calender A, and De Thé G: Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985;2(8452):407-410. (Pubitemid 15231248)
4. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, and Tara M: HTLV-I associated myelopathy, a new clinical entity. Lancet 1986;1(8488):1031-1032. (Pubitemid 16102987)
5. Mochizuki M, Watanabe T, Yamaguchi K, Takatsuki K, Yoshimura K, Shirao M, Nakashima S, Mori S, Araki S, and Miyata N: HTLV-I uveitis: A distinct clinical entity caused by HTLV-I. Jpn J Cancer Res 1992;83:236-239.
6. Nishioka K, Maruyama I, Sato K, Kitajima I, Nakajima Y, and Osame M: Chronic inflammatory arthropathy associated with HTLV-I. Lancet 1989;1(8635):441. (Pubitemid 19059182)
7. Morgan OStC, Mora C, Rodgers-Johnson P, and Char G: HTLV-1 and polymyositis in Jamaica. Lancet 1989;2:1184-1187
8. Vernant JC, Buisson GG, Sobesky G, Arfi S, Gervaise G, and Roman GC: Can HTLV-1 lead to immunological disease? (letter). Lancet 1987;2:404.
9. Verdonck K, Gonzalez E, Van Dooren S, Vandamme AM, Vanham G, and Gotuzzo E: Human T-lymphotropic virus 1: Recent knowledge about an ancient infection. Lancet Infect Dis 2007;7:266-281. (Pubitemid 46414075)
10. Yamaguchi K and Watanabe T: Human T lymphotropic virus type-I and adult T-cell leukemia in Japan. Int J Hematol 2002;76(2):240-245.
11. Murphy EL, Hanchard B, Figueroa JP, Gibbs WN, Lofters WS, Campbell M, Goedert JJ, and Blattner WA: Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. Int J Cancer 1989;43(2):250-253. (Pubitemid 19062419)
12. Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, and Yamaguchi K: Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: A nationwide prospective study in Japan. Blood 2010;116:1211-1219.
13. Kaplan JE, Osame M, Kubota H, Igata A, Nishitani H, Maeda Y, Khabbaz RF, and Janssen RS: The risk of development of HTLV-I-associated myelopathy/tropical spastic paraparesis among persons infected with HTLV-1. J Acquir Immune Defic Syndr 1990;3(11):1096-1101. (Pubitemid 20373639)
14. Maloney EM, Cleghorn FR, Morgan OS, Rodgers-Johnson P, Cranston B, Jack N, Blattner WA, Bartholomew C, and Manns A: Incidence of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica and Trinidad. J Acquir Immune Defic Syndr Hum Retrovirol 1998;17(2):167-170.
15. Richardson JH, Edwards AJ, Cruickshank JK, Rudge P, and Dalgleish AG: In vivo cellular tropism of human T-cell leukaemia virus type 1. J Virol 1990;64:5682-5687. (Pubitemid 20364571)
16. Gessain A, Gallo RC, and Franchini G: Low degree of human T-cell leukaemia-lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human population. J. Virol 1992;66: 2288-2295.
17. Wattel E, Vartanian J-P, Pannetier C, and Wain-Hobson S: Clonal expansion of human T-cell leukemia virus type I infected cells in asymptomatic and symptomatic carriers without malignancy. J Virol 1995;69:2863-2868.
18. Gillet NA, Malani N, Melamed A, Gormley N, Carter R, Bentley D, Berry C, Bushman FD, Taylor GP, and Bangham CR: The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones. Blood 2011;117:3113-3122
19. Tosswill JHC, Taylor GP, Clewley JP, and Weber JN: Quantification of proviral DNA in human T-cell leukaemia virus type I infection. J Virol Methods 1998;75:21-26. (Pubitemid 28495612)
20. Kwaan N, Lee T-H, Chafets DM, Nass C, Newman B, Smith J, Garratty G, and Murphy ED: Long-term variations in human T lymphotropic virus (HTLV)-1 and HTLV-2 proviral loads and association with clinical data. J Infect Dis 2006;194:1557-1564. (Pubitemid 44851897)
21. Asquith B and Bangham CR: Quantifying HTLV-I dynamics. Immunol Cell Biol 2007;85:280-286. (Pubitemid 46878928)
22. Ho D, Moudgil T, and Alam M: Quantification of human immunodeficiency virus type-1 in the blood of infected persons. N Engl J Med 1989;321:1621-1615.
23. Kamihira S, Dateki N, Sugahara K, Hayashi T, Harasawa H, Minami S, Hirakata Y, and Yamada Y: Significance of HTLV-1 proviral load quantification by real-time PCR as a surrogate marker for HTLV-1-infected cell count. Clin Lab Haematol 2003;25 (2):111-117. (Pubitemid 36458160)
24. Kira J, Koyanagi Y, Yamada T, Itoyama Y, Goto I, Yamamoto N, Sasaki H, and Sakaki Y: Increased HTLV-I proviral DNA in HTLV-I-associated myelopathy: A quantitative polymerase chain reaction study. Ann Neurol 1991;29(2): 194-201.
25. Manns A, Miley WJ, and Wilks RJ: Quantitative proviral DNA and antibody levels in the natural history of HTLV-1 infection. J Infect Dis 1999;180(5):1487-1493. (Pubitemid 29506449)
26. Nagai M, Usuku K, Matsumoto W, Kodama D, Takenouchi N, Moritoyo T, Hashiguchi S, Ichinose M, Bangham CRM, Izumo S, and Osame M: Analysis of HTLV-1 proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-1 carriers: High proviral load strongly predisposes to HAM/TSP. J Neurovirol 1998;4(6):586-593. (Pubitemid 29042065)
27. Olindo S, Lézin A, Cabre P, Merle H, Saint-Vil M, Edimonana Kaptue M, Signate A, Césaire R, and Smadja D: HTLV-1 proviral load in peripheral blood mononuclear cells quantified in 100 HAM/TSP patients: A marker of disease progression. J Neurol Sci 2005;237(1-2):53-59. (Pubitemid 41384014)
28. Taylor GP, Tosswill JH, Matutes E, Daenke S, Hall S, Bain BJ, Davis R,Thomas D, Rossor M, Bangham CR, and Weber JN: Prospective study of HTLVI infection in an initially asymptomatic cohort. J Acquir Immune Defic Syndr 1999;22: 92-100. (Pubitemid 29486915)
29. Hisada M, Okayama A, Shioiri S, Spiegelman DL, Stuver SO, and Mueller NE: Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I. Blood 1998;92:3557-3561. (Pubitemid 28525179)
30. Okayama A, Stuver S, Matsuoka M, Ishizaki J, Tanaka G, Kubuki NM, Hsieh C, Tachibana N, and Tsubouchi H: Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia/lymphoma in asymptomatic carriers. Int J Cancer 2004;110:621-625. (Pubitemid 38658030)
31. Kwok S, Ehrlich G, Poiesz B, Kalish R, and Sninsky JJ: Enzymatic amplification of HTLV-1 viral sequences from peripheral blood mononuclear cells and infected tissues. Blood 1988;72(4):1117-1123. (Pubitemid 18265868)
32. Takenouchi N, Yamano Y, Usuku K, Osame M, and Izumo S: Usefulness of proviral load measurement for monitoring of disease activity in individual patients with human Tlymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol 2003;9(1):29-35. (Pubitemid 36372543)
33. Lezin A, Olindo S, Oliere S, Varrin-Doyer M, Marlin R, Cabre P, Smadja D, and Cesaire R: Human T lymphotropic virus type I (HTLV-I) proviral load in cerebrospinal fluid: A new criterion for the diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis? J Infect Dis 2005; 191(11):1830-1834. (Pubitemid 40705389)
34. Martin F, Castro H, Gabriel C, Adonis A, Fedina A, Harrison L, Brodnicki L, Demontis MA, Babiker AG, Weber JN, Bangham CRM, and Taylor GP: Ciclosporin: A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. PLoS NTDS 2012;6(6):1675.