Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model

Brain and Behavior

Volumn 2, Issue 5, 2012, Pages 698-706

  Pollak, Julia ^a   Doyle, Kristian P ^a   Mamer, Lauren ^a   Shamloo, Mehrdad ^a   Buckwalter, Marion S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Behavior; Hypoxic ischemic stroke; Motor recovery; Mouse model

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONVALESCENCE; CORRELATION ANALYSIS; ELEVATED BODY SWING TEST; FEMALE; FUNCTION TEST; GAIT; HORIZONTAL LADDER TEST; MALE; MORTALITY; MOUSE; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; REPRODUCIBILITY; ROTAROD TEST;

EID: 84886287240     PISSN: None     EISSN: 21623279     Source Type: Journal    
DOI: 10.1002/brb3.77     Document Type: Article

References (19)

1. Adhami, F., G. Liao, Y. M. Morozov, A. Schloemer, V. J. Schmithorst, J. N. Lorenz, etal. 2006. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am. J. Pathol. 169:566-583.
2. Andres, R. H., R. Choi, A. V. Pendharkar, X. Gaeta, N. Wang, J. K. Nathan, etal. 2011. The CCR2/CCL2 interaction mediates the transendothelial recruitment of intravascularly delivered neural stem cells to the ischemic brain. Stroke 42:2923-2931.
3. Barone, F. C., D. J. Knudsen, A. H. Nelson, G. Z. Feuerstein, and R. N. Willette 1993. Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J. Cereb. Blood Flow Metab. 13:683-692.
4. Borlongan, C. V., and P. R. Sanberg 1995. Elevated body swing test: a new behavioral parameter for rats with 6-hydroxydopamine-induced hemiparkinsonism. J. Neurosci. 15:5372-5378.
5. Clarkson, A. N., B. S. Huang, S. E. Macisaac, I. Mody, and S. T. Carmichael 2010. Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature 468:305-309.
6. Clarkson, A. N., J. J. Overman, S. Zhong, R. Mueller, G. Lynch, and S. T. Carmichael 2011. AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke. J. Neurosci. 31:3766-3775.
7. Farr, T. D., L. Liu, K. L. Colwell, I. Q. Whishaw, and G. A. Metz 2006. Bilateral alteration in stepping pattern after unilateral motor cortex injury: a new test strategy for analysis of skilled limb movements in neurological mouse models. J. Neurosci. Methods 153:104-113.
8. Fujii, M., H. Hara, W. Meng, J. P. Vonsattel, Z. Huang, and M. A. Moskowitz 1997. Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice. Stroke 28:1805-1810; discussion 1811.
9. Guzman, R., A. De Los Angeles, S. Cheshier, R. Choi, S. Hoang, J. Liauw, etal. 2008. Intracarotid injection of fluorescence activated cell-sorted CD49d-positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model. Stroke 39:1300-1306.
10. Han, J., J. Pollak, T. Yang, M. R. Siddiqui, K. D. Doyle, K. Taravosh-Lahn, etal. 2012. A small molecule TrkB ligand promotes recovery when started 3days after stroke. Stroke 43:1918-1924.
11. Kuan, C. Y., A. J. Whitmarsh, D. D. Yang, G. Liao, A. J. Schloemer, C. Dong, etal. 2003. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc. Natl. Acad. Sci. USA 100:15184-15189.
12. Levine, S. 1960. Anoxic-ischemic encephalopathy in rats. Am. J. Pathol. 36:1-17.
13. McCullough, L. D., and P. D. Hurn 2003. Estrogen and ischemic neuroprotection: an integrated view. Trends Endocrinol. Metab. 14:228-235.
14. Metz, G. A., and I. Q. Whishaw 2002. Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination. J. Neurosci. Methods 115:169-179.
15. Olson, E. E., and R. J. McKeon 2004. Characterization of cellular and neurological damage following unilateral hypoxia/ischemia. J. Neurol. Sci. 227:7-19.
16. Olson, E. E., P. Lyuboslavsky, S. F. Traynelis, and R. J. McKeon 2004. PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia. J. Cereb. Blood Flow Metab. 24:964-971.
17. Roger, V. L., A. S. Go, D. M. Lloyd-Jones, E. J. Benjamin, J. D. Berry, W. B. Borden, etal. 2012. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 125:e2-e220.
18. Shyu, W. C., S. Z. Lin, H. I. Yang, Y. S. Tzeng, C. Y. Pang, P. S. Yen, etal. 2004. Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation 110:1847-1854.
19. STEPS Participants. 2009. Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke 40:510-515.