Increased expression of the transient receptor potential cation channel 6 gene in patients with primary open-angle glaucoma

Clinical and Experimental Ophthalmology

Volumn 41, Issue 8, 2013, Pages 753-760

  Chen, Shida ^a   Fan, Qian ^a   Gao, Xinbo ^a   Wang, Xiaolei ^b   Huang, Rui ^a   Laties, Alan M ^c   Zhang, Xiulan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Intraocular pressure (IOP); Primary open angle glaucoma (POAG); TRPC6

Indexed keywords

MESSENGER RNA; ANTIHYPERTENSIVE AGENT; GENETIC MARKER; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN;

ADULT; AGE; ARTICLE; CATARACT; CLINICAL EXAMINATION; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; HUMAN; INTRAOCULAR PRESSURE; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; OPEN ANGLE GLAUCOMA; OPTIC DISK CUP; PATHOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL 6 GENE; VISUAL FIELD; VISUAL FIELD DEFECT; AGED; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; GLAUCOMA, OPEN-ANGLE; METABOLISM; MIDDLE AGED; OCULOPLETHYSMOGRAPHY; PERIMETRY; PHYSIOLOGY;

AGED; ANTIHYPERTENSIVE AGENTS; FEMALE; GENE EXPRESSION REGULATION; GENETIC MARKERS; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TONOMETRY, OCULAR; TRPC CATION CHANNELS; VISUAL FIELD TESTS;

EID: 84886283902     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/ceo.12111     Document Type: Article

References (45)

1. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006; 90: 262-267.
2. Quigley HA. Glaucoma. Lancet 2011; 377: 1367-1377.
3. Bahrami H. Causal inference in primary open angle glaucoma: specific discussion on intraocular pressure. Ophthalmic Epidemiol 2006; 13: 283-289.
4. Caprioli J, Coleman AL. Discussion BFiG blood pressure, perfusion pressure, and glaucoma. Am J Ophthalmol 2010; 149: 704-712.
5. Rudnicka AR, Mt-Isa S, Owen CG, Cook DG, Ashby D. Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis. Invest Ophthalmol Vis Sci 2006; 47: 4254-4261.
6. Rakhmanov VV, Nikitina NIa, Zakharova FM etal. [Mutations and polymorphisms in the genes for myocilin and optineur in as the risk factors of primary open-angle glaucoma]. Genetika 2005; 41: 1567-1574.
7. Bonovas S, Peponis V, Filioussi K. Diabetes mellitus as a risk factor for primary open-angle glaucoma: a meta-analysis. Diabet Med 2004; 21: 609-614.
8. Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey. Arch Ophthalmol 1994; 112: 69-73.
9. Fingert JH. Primary open-angle glaucoma genes. Eye (Lond) 2011; 25: 587-595.
10. Fan BJ, Wang DY, Lam DS, Pang CP. Gene mapping for primary open angle glaucoma. Clin Biochem 2006; 39: 249-258.
11. Monemi S, Spaeth G, DaSilva A etal. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Hum Mol Genet 2005; 14: 725-733.
12. Fingert JH, Alward WL, Kwon YH etal. No association between variations in the WDR36 gene and primary open-angle glaucoma. Arch Ophthalmol 2007; 125: 434-436.
13. Gemenetzi M, Yang Y, Lotery AJ. Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment. Eye (Lond) 2012; 26: 355-369.
14. Christensen AP, Corey DP. TRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci 2007; 8: 510-521.
15. Corey DP. New TRP channels in hearing and mechanosensation. Neuron 2003; 39: 585-588.
16. Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007; 87: 165-217.
17. Clapham DE. TRP channels as cellular sensors. Nature 2003; 426: 517-524.
18. Reiser J, Polu KR, Möller CC etal. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 2005; 37: 739-744.
19. Beech DJ, Muraki K, Flemming R. Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP. J Physiol 2004; 559: 685-706.
20. Welsh DG, Morielli AD, Nelson MT, Brayden JE. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 2002; 90: 248-250.
21. Yu Y, Keller SH, Remillard CV etal. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation 2009; 119: 2313-2322.
22. Gigante M, Caridi G, Montemurno E etal. TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype. Clin J Am Soc Nephrol 2011; 6: 1626-1634.
23. Mir S, Yavascan O, Berdeli A, Sozeri B. TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome. Nephrol Dial Transplant 2012; 27: 205-209.
24. Winn MP, Conlon PJ, Lynn KL etal. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 2005; 308: 1801-1804.
25. Wang X, Teng L, Li A, Ge J, Laties AM, Zhang X. TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. Invest Ophthalmol Vis Sci 2010; 51: 5751-5758.
26. Li A, Zhang X, Zheng D, Ge J, Laties AM, Mitchell CH. Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma. Exp Eye Res 2011; 93: 528-533.
27. Lederman M, Weiss A, Chowers I. Association of neovascular age-related macular degeneration with specific gene expression patterns in peripheral white blood cells. Invest Ophthalmol Vis Sci 2010; 51: 53-58.
28. Bayer A, Harasymowycz P, Henderer JD, Steinmann WG, Spaeth GL. Validity of a new disk grading scale for estimating glaucomatous damage: correlation with visual field damage. Am J Ophthalmol 2002; 133: 758-763.
29. Spassova MA, Hewavitharana T, Xu W, Soboloff J, Gill DL. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A 2006; 103: 16586-16591.
30. Da Silva N, Herron CE, Stevens K, Jollimore CA, Barnes S, Kelly ME. Metabotropic receptor-activated calcium increases and store-operated calcium influx in mouse Müller cells. Invest Ophthalmol Vis Sci 2008; 49: 3065-3073.
31. Krizaj D. Compartmentalization of calcium entry pathways in mouse rods. Eur J Neurosci 2005; 22: 3292-3296.
32. Sekaran S, Lall GS, Ralphs KL etal. 2-Aminoethoxydiphenylborane is an acute inhibitor of directly photosensitive retinal ganglion cell activity in vitro and in vivo. J Neurosci 2007; 27: 3981-3986.
33. Perez-Leighton CE, Schmidt TM, Abramowitz J, Birnbaumer L, Kofuji P. Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits. Eur J Neurosci 2011; 33: 856-867.
34. Szikra T, Cusato K, Thoreson WB, Barabas P, Bartoletti TM, Krizaj D. Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors. J Physiol 2008; 586: 4859-4875.
35. Jia Y, Zhou J, Tai Y, Wang Y. TRPC channels promote cerebellar granule neuron survival. Nat Neurosci 2007; 10: 559-567.
36. Li Y, Jia YC, Cui K etal. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature 2005; 434: 894-898.
37. Tai Y, Feng S, Ge R etal. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci 2008; 121: 2301-2307.
38. Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 2012; 31: 152-181.
39. Du X, Tang Y, Xu H etal. Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics 2006; 87: 693-703.
40. Iglesias AH, Camelo S, Hwang D, Villanueva R, Stephanopoulos G, Dangond F. Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J Neuroimmunol 2004; 150: 163-177.
41. Bennett L, Palucka AK, Arce E etal. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003; 197: 711-723.
42. Ghanem AA, Arafa LF, El-Baz A. Oxidative stress markers in patients with primary open-angle glaucoma. Curr Eye Res 2010; 35: 295-301.
43. Petzold A, Junemann A, Rejdak K etal. A novel biomarker for retinal degeneration: vitreous body neurofilament proteins. J Neural Transm 2009; 116: 1601-1606.
44. Kowalski M, Walczak A, Majsterek I. [Matrix metalloproteinases (MMPs): modern molecular markers of open-angle glaucoma diagnosis and therapy]. Postepy Hig Med Dosw (Online) 2008; 62: 582-592.
45. Golubnitschaja O, Flammer J. What are the biomarkers for glaucoma? Surv Ophthalmol 2007; 52 (Suppl. 2): S155-161.