Heritability of objectively assessed daily physical activity and sedentary behavior

American Journal of Clinical Nutrition

Volumn 98, Issue 5, 2013, Pages 1317-1325

  Den Hoed, Marcel ^a,b   Brage, Søren ^a   Zhao, Jing Hua ^a   Westgate, Kate ^a   Nessa, Ayrun ^c   Ekelund, Ulf ^a,d   Spector, Tim D ^c   Wareham, Nicholas J ^a   Loos, Ruth J F ^a,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UPPSALA UNIVERSITY   (Sweden)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d NORWEGIAN SCHOOL OF SPORT SCIENCES   (Norway)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCELEROMETER; ADULT; AGED; ARTICLE; BODY MASS; BODY MOVEMENT; DAILY LIFE ACTIVITY; DIZYGOTIC TWINS; ENERGY EXPENDITURE; ENVIRONMENTAL FACTOR; FEMALE; GENETIC TRAIT; GENETIC VARIABILITY; HEART RATE; HERITABILITY; HUMAN; MALE; MONOZYGOTIC TWINS; PHYSICAL ACTIVITY; SEDENTARY LIFESTYLE; SENSOR; STRUCTURAL EQUATION MODELING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; ENERGY METABOLISM; ENVIRONMENT; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; MALE; MIDDLE AGED; MOTOR ACTIVITY; PHENOTYPE; SEDENTARY LIFESTYLE; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; YOUNG ADULT;

EID: 84886245515     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.113.069849     Document Type: Article

References (66)

1. Ravussin E, Swinburn BA. Pathophysiology of obesity. Lancet 1992; 340:404-8.
2. Ekelund U, Brage S, Franks PW, Hennings S, Emms S, Wareham NJ. Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-Aged healthy Caucasians: the Medical Research Council Ely Study. Diabetes Care 2005;28:1195-200.
3. Ekelund U, Brage S, Franks PW, Hennings S, Emms S, Wong MY, Wareham NJ. Physical activity energy expenditure predicts changes in body composition in middle-Aged healthy whites: effect modification by age. Am J Clin Nutr 2005;81:964-9.
4. Ekelund U, Franks PW, Sharp S, Brage S, Wareham NJ. Increase in physical activity energy expenditure is associated with reduced metabolic risk independent of change in fatness and fitness. Diabetes Care 2007;30:2101-6.
5. Ekelund U, Luan J, Sherar LB, Esliger DW, Griew P, Cooper A. International Children's Accelerometry Database C. Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents. JAMA 2012;307:704-12. (Published erratum appears in JAMA 2012;307:1915.)
6. Owen CG, Nightingale CM, Rudnicka AR, Sattar N, Cook DG, Ekelund U, Whincup PH. Physical activity, obesity and cardiometabolic risk factors in 9-To 10-year-old UK children of white European, South Asian and black African-Caribbean origin: the Child Heart And health Study in England (CHASE). Diabetologia 2010;53:1620-30.
7. Ekelund U, Griffin SJ, Wareham NJ. Physical activity and metabolic risk in individuals with a family history of type 2 diabetes. Diabetes Care 2007;30:337-42.
8. Højbjerre L, Sonne MP, Alibegovic AC, Dela F, Vaag A, Meldgaard JB, Christensen KB, Stallknecht B. Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes. Diabetes 2010;59:2790-8.
9. Lipman RL, Raskin P, Love T, Triebwasser J, Lecocq FR, Schnure JJ. Glucose intolerance during decreased physical activity in man. Diabetes 1972;21:101-7.
10. Bauman AE, Reis RS, Sallis JF, Wells JC, Loos RJ, Martin BW. Correlates of physical activity: why are some people physically active and others not? Lancet 2012;380:258-71.
11. Rundquist EA. Inheritance of spontaneous activity in rats. J Comp Psychol 1933;16:415-38.
12. Cai G, Cole SA, Butte N, Bacino C, Diego V, Tan K, Goring HH, O'Rahilly S, Farooqi IS, Comuzzie AG. A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children. Obesity (Silver Spring) 2006;14:1596-604.
13. Choh AC, Demerath EW, Lee M, Williams KD, Towne B, Siervogel RM, Cole SA, Czerwinski SA. Genetic analysis of self-reported physical activity and adiposity: the Southwest Ohio Family Study. Public Health Nutr 2009;12:1052-60.
14. Mitchell BD, Rainwater DL, Hsueh WC, Kennedy AJ, Stern MP, Maccluer JW. Familial aggregation of nutrient intake and physical activity: results from the San Antonio Family Heart Study. Ann Epidemiol 2003;13:128-35.
15. Pérusse L, Tremblay A, Leblanc C, Bouchard C. Genetic and environmental influences on level of habitual physical activity and exercise participation. Am J Epidemiol 1989;129:1012-22.
16. Simonen RL, Pérusse L, Rankinen T, Rice T, Rao DC, Bouchard C. Familial aggregation of physical activity levels in the Quebec Family Study. Med Sci Sports Exerc 2002;34:1137-42.
17. Aaltonen S, Ortega-Alonso A, Kujala UM, Kaprio J. A longitudinal study on genetic and environmental influences on leisure time physical activity in the Finnish Twin Cohort. Twin Res Hum Genet 2010;13: 475-81.
18. Carlsson S, Andersson T, Lichtenstein P, Michaelsson K, Ahlbom A. Genetic effects on physical activity: results from the Swedish Twin Registry. Med Sci Sports Exerc 2006;38:1396-401.
19. Eriksson M, Rasmussen F, Tynelius P. Genetic factors in physical activity and the equal environment assumption-The Swedish young male twins study. Behav Genet 2006;36:238-47.
20. Fisher A, van Jaarsveld CH, Llewellyn CH, Wardle J. Environmental influences on children's physical activity: quantitative estimates using a twin design. PLoS ONE 2010;5:e10110.
21. Franks PW, Ravussin E, Hanson RL, Harper IT, Allison DB, Knowler WC, Tataranni PA, Salbe AD. Habitual physical activity in children: the role of genes and the environment. Am J Clin Nutr 2005;82:901-8.
22. Joosen AM, Gielen M, Vlietinck R,Westerterp KR. Genetic analysis of physical activity in twins. Am J Clin Nutr 2005;82:1253-9.
23. Maia JA, Thomis M, Beunen G. Genetic factors in physical activity levels: a twin study. Am J Prev Med 2002;23(suppl):87-91.
24. Stubbe JH, Boomsma DI, Vink JM, Cornes BK, Martin NG, Skytthe A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, et al. Genetic influences on exercise participation in 37,051 twin pairs from seven countries. PLoS ONE 2006;1:e22.
25. Helmerhorst HJ, Brage S, Warren J, Besson H, Ekelund U. A systematic review of reliability and objective criterion-related validity of physical activity questionnaires. Int J Behav Nutr Phys Act 2012;9:103.
26. Moayyeri A, Hammond CJ, Valdes AM, Spector TD. Cohort profile: TwinsUK and healthy ageing twin study. Int J Epidemiol 2013;42: 76-85.
27. Brage S, Brage N, Franks PW, Ekelund U, Wareham NJ. Reliability and validity of the combined heart rate and movement sensor Actiheart. Eur J Clin Nutr 2005;59:561-70.
28. Stegle O, Fallert SV, MacKay DJ, Brage S. Gaussian process robust regression for noisy heart rate data. IEEE Trans Biomed Eng 2008;55: 2143-51.
29. Levin S, Jacobs DR Jr, Ainsworth BE, Richardson MT, Leon AS. Intraindividual variation and estimates of usual physical activity. Ann Epidemiol 1999;9:481-8.
30. Matthews CE, Ainsworth BE, Thompson RW, Bassett DR Jr. Sources of variance in daily physical activity levels as measured by an accelerometer. Med Sci Sports Exerc 2002;34:1376-81.
31. Brage S, Ekelund U, Brage N, Hennings MA, Froberg K, Franks PW, Wareham NJ. Hierarchy of individual calibration levels for heart rate and accelerometry to measure physical activity. J Appl Physiol 2007; 103:682-92.
32. The Interact Consortium. Validity of a short questionnaire to assess physical activity in 10 European countries. Eur J Epidemiol 2012;27: 15-25.
33. Brage S, Brage N, Franks PW, Ekelund U, Wong MY, Andersen LB, Froberg K, Wareham NJ. Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure. J Appl Physiol 2004; 96:343-51.
34. Henry CJ. Basal metabolic rate studies in humans: measurement and development of new equations. Public Health Nutr 2005;8:1133-52.
35. Brandes M, VAN Hees VT, Hannöver V, Brage S. Estimating energy expenditure from raw accelerometry in three types of locomotion. Med Sci Sports Exerc 2012;44:2235-42.
36. Woodward MI, Cunningham JL. Skeletal accelerations measured during different exercises. Proc Inst Mech Eng H 1993;207:79-85.
37. Boker S, Neale M, Maes H, Wilde M, Spiegel M, Brick T, Spies J, Estabrook R, Kenny S, Bates T, et al. OpenMx: an open source extended structural equation modeling framework. Psychometrika 2011; 76:306-17.
38. Neale MCCL. Methodology for genetic studies of twins and families. Dordrecht, Netherlands: Kluwer Academic, 1992.
39. Peng Q, Zhao J, Xue F. PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs. BMC Genet 2010;11:6.
40. Ekelund U, Aman J, Yngve A, Renman C, Westerterp K, Sjostrom M. Physical activity but not energy expenditure is reduced in obese adolescents: a case-control study. Am J Clin Nutr 2002;76:935-41.
41. Chirico AM, Stunkard AJ. Physical activity an human obesity. N Engl J Med 1960;263:935-40.
42. Elks CE, den Hoed M, Zhao JH, Sharp SJ, Wareham NJ, Loos RJF, Ong KK. Variability in the heritability of body masss index: a systematic review and meta-regression. Front Endocrinol (Lausanne) 2012;3:29.
43. Bonomi AG, Goris AH, Yin B, Westerterp KR. Detection of type, duration, and intensity of physical activity using an accelerometer. Med Sci Sports Exerc 2009;41:1770-7.
44. Carr LJ, Mahar MT. Accuracy of intensity and inclinometer output of three activity monitors for identification of sedentary behavior and light-intensity activity. J Obes 2012;2012:460271.
45. Stubbe JH, Boomsma DI, De Geus EJ. Sports participation during adolescence: a shift from environmental to genetic factors. Med Sci Sports Exerc 2005;37:563-70.
46. Plasqui G, Joosen AM, Kester AD, Goris AH, Westerterp KR. Measuring free-living energy expenditure and physical activity with triaxial accelerometry. Obes Res 2005;13:1363-9.
47. Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Hakkinen K, Jenkins NT, Karavirta L, Kraus WE, Leon AS, et al. Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS ONE 2012;7:e37887.
48. Lightfoot JT. Current understanding of the genetic basis for physical activity. J Nutr 2011;141:526-30.
49. Knab AM, Bowen RS, Hamilton AT, Gulledge AA, Lightfoot JT. Altered dopaminergic profiles: implications for the regulation of voluntary physical activity. Behav Brain Res 2009;204:147-52.
50. Rhodes JS, Garland T. Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology (Berl) 2003;167:242-50.
51. Fox DL, Vella KR, Good DJ. Energy balance pathways converging on the Nhlh2 transcription factor. Front Biosci 2007;12:3983-93.
52. Good DJ, Coyle CA, Fox DL. Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity. Exerc Sport Sci Rev 2008; 36:187-92.
53. Loos RJ, Rankinen T, Tremblay A, Pérusse L, Chagnon Y, Bouchard C. Melanocortin-4 receptor gene and physical activity in the Quebec Family Study. Int J Obes (Lond) 2005;29:420-8.
54. Lorentzon M, Lorentzon R, Lerner UH, Nordstrom P. Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls. Eur J Endocrinol 2001;144:257-61.
55. Richert L, Chevalley T, Manen D, Bonjour JP, Rizzoli R, Ferrari S. Bone mass in prepubertal boys is associated with a Gln223Arg amino acid substitution in the leptin receptor. J Clin Endocrinol Metab 2007; 92:4380-6.
56. Stefan N, Vozarova B, Del Parigi A, Ossowski V, Thompson DB, Hanson RL, Ravussin E, Tataranni PA. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. Int J Obes Relat Metab Disord 2002;26:1629-32.
57. Winnicki M, Accurso V, Hoffmann M, Pawlowski R, Dorigatti F, Santonastaso M, Longo D, Krupa-Wojciechowska B, Jeunemaitre X, Pessina AC, et al. Physical activity and angiotensin-converting enzyme gene polymorphism in mild hypertensives. Am J Med Genet A 2004; 125A:38-44.
58. de Vilhena e Santos DM, Katzmarzyk PT, Seabra AF, Maia JA. Genetics of physical activity and physical inactivity in humans. Behav Genet 2012;42:559-78.
59. De Moor MH, Posthuma D, Hottenga JJ, Willemsen G, Boomsma DI, De Geus EJ. Genome-wide linkage scan for exercise participation in Dutch sibling pairs. European journal of human genetics. Eur J Hum Genet 2007;15:1252-9.
60. Simonen RL, Rankinen T, Pérusse L, Rice T, Rao DC, Chagnon Y, Bouchard C. Genome-wide linkage scan for physical activity levels in the Quebec Family study. Med Sci Sports Exerc 2003;35:1355-9.
61. De Moor MH, Liu YJ, Boomsma DI, Li J, Hamilton JJ, Hottenga JJ, Levy S, Liu XG, Pei YF, Posthuma D, et al. Genome-wide association study of exercise behavior in Dutch and American adults. Med Sci Sports Exerc 2009;41:1887-95.
62. Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PI, Yin X, Estrada K, Bis JC, Marciante K, Rivadeneira F, Noseworthy PA, et al. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 2009;41:399-406.
63. Sotoodehnia N, Isaacs A, de Bakker PI, Dorr M, Newton-Cheh C, Nolte IM, van der Harst P, Muller M, Eijgelsheim M, Alonso A, et al. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet 2010;42:1068-76.
64. Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikainen LP, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-Analysis of 45,891 individuals. PLoS Genet 2012;8:e1002607.
65. Klesges RC, Williamson JE, Somes GW, Talcott GW, Lando HA, Haddock CK. A population comparison of participants and nonparticipants in a health survey. Am J Public Health 1999;89:1228-31.
66. Lynch WD, Golaszewski TJ, Clearie A, Vickery DM. Characteristics of self-selected responders to a health risk appraisal: generalizability of corporate health assessments. Am J Public Health 1989;79:887-8.