SPR-Based Direct Binding Assays in Drug Discovery

Label-Free Technologies for Drug Discovery

Volumn , Issue , 2011, Pages 269-282

  Huber, Walter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Assay set up SPR measurements, performed on a Biacore S51 instrument; High quality hit and lead compound identification in discovery of new drug molecules; Lead selection, using SPR based binding assay interaction of potential lead candidates; Ratio of responses, at two different concentrations early filter criterion for selection of positive hits; Screening using SPR based direct binding assay pharmaceutical industry, exploring new and innovative methods, discovering small molecule drug candidates; Selection filters, and respective assay types in screening assays; Single concentration affinity filter measured responses at given concentration; SPR based direct binding assays in drug discovery

Indexed keywords

EID: 84886159918     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470979129.ch18     Document Type: Chapter

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