Rational design of molecules by life cycle engineering

Green and Sustainable Pharmacy

Volumn , Issue , 2010, Pages 135-146

  Kümmerer, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84886113915     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-05199-9_9     Document Type: Chapter

References (46)

1. Anastas PT, Warner JC (1998) Green Chemistry: Theory and Practice. Oxford University Press, Oxford, New York
2. Boethling RS, Mackay D (2000) Handbook of Property Estimation Methods for Chemicals-Environmental and Health Sciences. Lewis Publisher, Boca Raton
3. Boethling RS, Sommer E, DiFiore D (2007) Designing small molecules for biodegradability. Chem Rev 107, 2207
4. Cairns J, Jr, Mount DI (1990) Aquatic toxicology. Part 2. Environ Sci Technol 24, 154-161
5. Calza P, Medana C, Carbone F, Giancotti V, Baiocchi C (2008) Characterization of intermediate compounds formed upon photoinduced degradation of quinolones by high-performance liquid chromatography/high-resolution multiple-stage mass spectrometry. Rapid Commun Mass Sp 22, 1533-1552
6. Clark JH (2006) Green chemistry: today (and tomorrow). Green Chem 8, 17-21
7. Clark JH, Smith P (2005) Basic principles of green chemistry. Innov Pharma Technol 16, 94-97
8. Daughton CG (2003) Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ Health Persp 111, 757-774
9. Dohmann M (2004) Maßnahmen zur Verringerung der Gewässerbelastung durch Arzneimittelrückstände und Umweltchemikalien. Gewässserschutz, Wasser, Abwasser 193, 25/7
10. Drewes JE, Heberer T, Reddersen K (2002) Fate of pharmaceuticals during indirect potable use. Water Sci Technol 46, 73-80
11. EU (2003) EU 2003 Directive 2003/87/EC of the European Parliament and of the Council of 13 October 2003 establishing a scheme for greenhouse gas emission allowance trading within the Community and amending Council Directive 96/61/EC, L 275/32 EN Official Journal of the European Union 25.10.2003
12. Ekins S (ed.) (2007) Computational Toxicology. John Wiley and Sons, Hoboken
13. El-Khateeb M, Appleton TG, Charles BG, Gahan LR (1999) Development of HPLC conditions for valid determination of hydrolysis products of cisplatin. J Pharm Sci 88, 319-326
14. Götz K, Keil F (2007) Medikamentenentsorgung in privaten Haushalten: Ein Faktor bei der Gewässerbelastung mit Arzneimittelwirkstoffen? 9 UWSF 19, 180-88
15. Heberer T, Feldmann D (2005) Contribution of effluents from hospitals and private households to the total loads of diclofenac and carbamazepine in municipal sewage effluents-modeling versus measurements. J Hazard Mater 122, 211-218
16. Isidori M, Lavorgna M, Nardelli A, Parrella A, Previtera L, Rubino M (2005) Ecotoxicity of naproxen and its phototransformation products. Sci Total Environ 348, 93-101
17. Isidori M, Nardelli A, Pascarella M, Rubino M, Pascarella A (2007) Toxic and genotoxic impact of fibrates and their protoproducts on non-target organisms. Envrion Int 33, 635-641
18. Jones OHA, Green PG, Voulvoulis N, Lester JN (2007) Questioning the excessive use of advanced treatment to remove organic micro-pollutants from waste water. Environ Sci Technol 41, 5085-5089
19. Kümmerer K (1996) The ecological impact of time. Time Soc 5(219-235), 1996
20. Kümmerer K (2007) Sustainable from the very beginning: rational design of molecules by life cycle engineering as an important approach for green pharmacy and green chemistry. Green Chem 9, 899-907
21. Kümmerer K (2008) Strategies for the Reduction the Input of Pharmaceuticals into the Environment. In: Kümmerer K (ed.) Pharmaceuticals in the Environment. Sources, Fate, Effects and Risk. 3rd edition, Springer Publisher, Berlin Heidelberg New York, 433-440
22. Kümmerer K (2010) Design of Inherently Safe Molecules. In: Nelson W (ed.) Oxford Handbook of Green Chemistry: From Molecular Design to Process Scale Up. Oxford University Press, Oxford, New York, in press
23. Kümmerer K, Al-Ahmad A (1997) Biodegradability of the anti-tumor agents 5-fluorouracil, cytarabine and gemcitabine: impact of the chemical structure and synergistic toxicity with hospital effluents. Acta Hydroch Hydrob 25, 166-172
24. Kümmerer K, Al-Ahmad A, Bertram B,WießlerM(2000) Biodegradability of antineoplastic compounds in screening tests: improvement by glucosidation and influence of stereo-chemistry. Chemosphere 40, 767-773
25. Kümmerer K, Velo G (2006) A new topic of importance in pharmacovigilance. Drug Safety 29, 371-373
26. Längin A, Alexy R, König A, Kümmerer K (2009) Deactivation and transformation products in biodegradability testing of ß-lactams amoxicillin and piperacillin. Chemosphere 75, 347-354
27. Lee C, Lee Y, Schmidt C, Yoon J, von Gunten U (2007) Oxidation of N-nitrosodimethylamine (NDMA) with ozone and chlorine dioxide: kinetics and effect on NDMA formation potential. Environ Sci Technol 41, 2056-2063
28. Li K, Yediler A, Yang M, Schulte-Hostede S, Wong MH (2008) Ozonation of oxytetracycline and toxicological assessment of its oxidation by-products. Chemosphere 72, 473-478
29. Matamoros V, Bayona JM (2006) Elimination of pharmaceuticals and personal care products in subsurface flow constructed wetlands. Environ Sci Technol 40, 5811-5816
30. 2 and simulated solar irradiation. Water Res 42, 585-594
31. Metzger S, Kapp H, Seitz W, Weber WH, Hiller G, Süßmuth W (2005) Entfernung von iodierten Röntgenkontrastmitteln bei der kommunalen Abwasserbehandlung durch den Einsatz von Pulveraktivkohle. GWF Wasser Abwasser 9, 638-645
32. Naddeo V, MeriçS, Kassinos D, Belgiorno V, Guida M (2009) Fate of pharmaceuticals in contaminated urban wastewater effluent under ultrasonic irradiation. Water Res 2009 May 28. [Epub ahead of print]
33. Nowotny N, Epp B, von Sonntag C, Fahlenkamp H (2007) Quantification and modeling of the elimination behavior of ecologically problematic wastewater micropollutants by adsorption on powdered and granulated activated carbon. Environ Sci Technol 41, 2050-2055
34. Qiting J, Xiheng Z (1988) Combination process of anaerobic digestion and ozonization technology for treating wastewater from antibiotics production. Water Treat 3, 285-291
35. Ravina M, Campanella L, Kiwi J (2002) Accelerated mineralization of the drug diclofenac via Fenton reactions in a concentric photo-reactor. Water Res 36, 3553-3560
36. Rizzo L, Meric S, Guida M, Kassinos D, Belgiorno V (2009) Heterogenous photocatalytic degradation kinetics and detoxification of an urban wastewater treatment plant effluent contaminated with pharmaceuticals. Water Res. 2009 June 27. [Epub ahead of print]
37. ScheringerM, Dunn MJ (2002) Persistence and Spatial Range of Environmental Chemicals.Wiley VCH, Weinheim
38. Schröder HF (2002) Mass spectrometric monitoring of the degradation and elimination efficiency for hardly eliminable and hardly biodegradable polar compounds by membrane bioreactors. Water Sci Technol 46, 57-64
39. Schulte-Oehlmann U, Oehlmann J, Püttman W (2007) Arzneimittelwirkstoffe in der Umwelt-Einträge, Vorkommen und der Versuch einer Bestandsaufnahme. UWSF 19, 168-179
40. Strässle R (2007) Mikroverunreinigung: Ozon als Lösung? Umwelt Perspektiven 8, 34-37
41. Ternes TA, Joss A (eds.) (2006) Human Pharmaceuticals, Hormones and Fragrances-The Challenge of Micropollutants in Urban Water Management. IWA Publishing, London
42. Vasconcelos TG, Henriques DM, König A, Martins AF, Kümmerer K (2009b) Photo-degradation of the antimicrobial ciprofloxacin at high pH: identification and biodegradability assessment of the primary by-products. Chemosphere 76, 487-493
43. Vasconcelos TG, Kümmerer K, Henriques DM, Martins AF (2009a) Ciprofloxacin in hospital effluent: degradation by ozone and photoprocesses. J Hazard Mater 169, 1154-1158
44. Watkinson AJ, Murby EJ, Costanzo SD (2007) Removal of antibiotics in conventional and advanced wastewater treatment: implications for environmental discharge and wastewater recycling. Water Res 41, 4164-4176
45. Wei-Hsiang C, Young TM (2008) NDMA formation during chlorination and chloramination of aqueous diuron solutions. Environ Sci Technol 42, 1072-1077
46. Wenzel H, Larsen HF, Clauson-Kaas J, Høibye L, Jacobsen BN (2008) Weighing environmental advantages and disadvantages of advanced wastewater treatment of micro-pollutants using environmental life cycle assessment. Water Sci Technol 57, 27-32