Synthesis of 4-(2'-Methoxyphenyl)-1-[2'-(N-2″Pyridinyl)-p-[18F]Fluorobenzamido]Ethylpiperazine [18F]MPPF

Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography

Volumn 1, Issue , 2012, Pages 87-94

  Alvarez, Marion ^a   Le Bars, Didier ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

Serotonin 5 HT neurotransmission, physiologic function modulation; Synthesis of 4 (2' Methoxyphenyl) 1 2' (N 2'pyridinyl; Synthesis of 18F MPPF

Indexed keywords

EID: 84886110801     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118140345.ch10     Document Type: Chapter

References (33)

1. 18F]MPPF]. In: Molecular Imaging and Contrast Agent Database (MICAD) [database online]. Bethesda (MD): National Library of Medicine (US), NCBI; 2004-2010. Available at: http://micad.nih.gov.
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9. Enriched water, ROTEM, www.rotemi.co.il.
10. Target IBA Niobium Small Volume, www.iba.be.
11. Sep-Pak Light QMA Waters, ref WAT023525.
12. Eluent: for 10 vials, 70 mg potassium carbonate, Aldrich ref 367877-10G, in 3 mL water + 220 mg Kryptofix, Aldrich ref 29,111-0, in 3 mL acetonitrile SDS, ref 00637G16; 600 μL in each vial.
13. Nitro precursor ABX Radeberg Germany ref 3240, www.abx.de.
14. DMSO: Acros ref 326881000, used as received.
15. Water sterile for injection, Braun ref 014361.
16. MeOH, Sigma Aldrich ref 34860, used as received.
17. Sunfire™ Waters Prep C18 5 μm 10 × 250 mm, part no 186002564.
18. THF, Acros ref 164240025, used as received.
19. Sep-Pak Plus tC18 Waters ref WAT036810: Lemaire C, Plenevaux A, Aerts J, et al. J Labelled Comp Radiopharm 1999;42:63-75.
20. Absolute ethanol: AP-HP Ageps ref 3628442, 10 ml ampoules used as received.
21. Sterile Vial TC-ELU-10 IBA Molecular Imaging.
22. Sodium chloride ProAmp 0.9% solution for injection, Aguettant, Lyon, France.
23. Millex-MP sterile 0.22 μm filters, Millipore (part no. SLMPL25SS).
24. SunFire™ Waters C18 5 μm 4.6 × 30 mm part no 186002556, equilibrated 60 min before use.
25. MPPF standard, ABX ref 3250.
26. Type Polygram Sil G/UV254.
27. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).
28. pH-indicator sticks, Macherey-Nagel 92118.
29. Mock BH, Winkle W, Vavrek MT. Nucl Med Biol 1997;24:193-195.
30. Capintec, Inc., USA.
31. European Pharmacopeia Biological tests Endotoxins 2.06.14.
32. Fluid Media ref THIO-T 42074, TSB-T 42100, SAB B-T 42108, BioMÉrieux, France, www.biomerieux.fr.
33. European Pharmacopeia Biological tests Sterility 2.06.01.