Impact of vaginal ascorbic acid on abnormal vaginal microflora

Archives of Gynecology and Obstetrics

Volumn 288, Issue 5, 2013, Pages 1039-1044

  Zodzika, Jana ^a,b   Rezeberga, Dace ^a,b   Donders, Gilbert ^c   Vedmedovska, Natalija ^a   Vasina, Olga ^a,b   Pundure, Inara ^a   Bite, Ruta ^a   Silberga, Ingrida ^a   Socenova, Julija ^a   Melngaile, Olita ^a  

^a RIGA STRADINS UNIVERSITY   (Latvia)

^b RIGA EAST UNIVERSITY HOSPITAL   (Latvia)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Abnormal vaginal microflora; Pregnancy; Vaginal vitamin C; Wet mounts

Indexed keywords

ASCORBIC ACID;

ADULT; ARTICLE; BEDTIME DOSAGE; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; HUMAN; IRRITATION; LACTOBACILLUS; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; PH; PREGNANT WOMAN; PREMENOPAUSE; PRURITUS; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; VAGINA FLORA; VAGINA PH; VAGINITIS;

ADMINISTRATION, INTRAVAGINAL; ADULT; ASCORBIC ACID; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; LACTOBACILLUS; PREGNANCY; PREMENOPAUSE; VAGINA; VITAMINS; YOUNG ADULT;

EID: 84886100813     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-013-2876-y     Document Type: Article

References (26)

1. Redondo-Lopez V, Cook RL, Sobel JD (1990) Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev Infect Dis 12(5):856-872
2. Osset J, Bartolome RM, Garcia E, Andreu A (2011) Assessment of the capacity of Lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells. J Infect Dis 183(3):485-491
3. Amsel R, Totten PA, Spegiel CA (1983) Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 74:14-22
4. Donders GGG, Vereecken A, Bosmans E, Dekeersmaecker A, Salembier G, Spitz B (2002) Aerobic vagintis: abnormal vaginal flora entity that is distinct from bacterial vaginosis. Br J Obstet Gynecol 109:1-10
5. Hay PE, Lamont RF, Taylor-Robinson D, Morgan DJ, Ison C, Pearson J (1994) Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ 308(6924):295-298
6. Donders GG, Spitz B, Vereecken A, Van Bulck B (2008) The ecology of the vaginal flora at first prenatal visit is associated with preterm delivery and low birth weight. Open Infect Dis J 2:45-51
7. Soper DE, Bump RC, Hurt WG (1990) Bacterial vaginosis and trichomoniasis vaginitis are risk factors for cuff cellulitis after abdominal hysterectomy. Am J Obstet Gynecol 163:1016-1021
8. Wiesenfeld HC, Hillier SL, Krohn MA, Landers DV, Sweet RL (2003) Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection. Clin Infect Dis 36:663-668
9. Verstraelen H, Verhelst R (2009) Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev Anti Infect Ther 7(9):1109-1124
10. Brocklehurst P, Gordon A, Heatley E, Milan SJ (2013) Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev. doi: 10.1002/14651858
11. Austin MN, Beigi RH, Meyn LA, Hiller SL (2005) Microbiological response to treatment of bacterial vaginosis with topical clindamycin or metronidazole. J Clin Microbiol 43(9):4492-4497
12. Baltimore RS (2007) Consequences of prophylaxis for group B streptococcal infections of the neonate. Semin Perinatol 31(1):33-38
13. Polatti F, Rampino M, Mahnani P, Mascarucci P (2006) Vaginal pH-lowering effect of locally applies vitamin C in subjects with high vaginal pH. Gynecol Endocrinol 22(4):230-234
14. Petersen EE, Magnani P (2004) Efficacy and safety of Vitamin C vaginal tablets in the treatment of non-specific vaginitis. A randomized, double-blind, placebo-controlled study. Obstet Gynec 117:70-75
15. Petersen EE, Genet M, Caserini M, Palmieri R (2011) Efficacy of vitamin C vaginal tablets in the treatment of bacterial vaginosis: a randomized, double-blind, placebo-controlled clinical trial. Arzneimittelforschung 61(4):260-265
16. Donders GG, Caeyers T, Tydhof P, Riphagen I, Van den Bosch T, Bellen G (2007) Comparison of two types of dipsticks to measure vaginal pH in clinical practice. Eur J Obstet Gynecol Reprod Biol 134(2):220-224
17. Larsson PG, Platz-Christensen JJ (1990) Enumeration of clue cells in rehydrated air-dried vaginal wet smears for the diagnosis of bacterial vaginosis. Obstet Gynecol 76:727-730
18. Donders GG (1999) Microscopy of bacterial flora on fresh vaginal smears. Infect Dis Obstet Gynecol 7:126-127
19. Lamont RF, Duncan SL, Mandal D, Bassett P (2003) Intravaginal clindamycin to reduce preterm birth in women with abnormal genital tract flora. Obstet Gynecol 101:516-522
20. Carey J, Klebanoff MA, Hauth JC, Hillier SL, Thom EA, Ernest JM et al (2000) Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. N Engl J Med 342:534-540
21. Ugwumadu A, Reid F, Hay P, Manyonda I (2004) Natural history of bacterial vaginosis and intermediate flora in pregnancy and effect of oral clindamycin. Obstet Gynecol 104:114-119
22. Ugwumadu A, Manyonda I, Reid F, Hay P (2003) Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomized controlled trial. Lancet 361:983-988
23. Eckert LO (2006) Acute vulvovaginitis. N Engl J Med 355:1244-1252
24. Parent D, Bossens M, Bayot D, Kirkpatrick C, Graft F, Wilkinson FE, Kaiser RR et al (1996) Therapy of bacterial vaginosis using exogeneously-applied Lactobacilli acidophili and a low-dose of estriol: a placebo-controlled multicentric clinical trial. Arzneimittelforschung 46:68-73
25. Holley RL, Richter HE, Varner RE, Pair L, Schwebke JR (2004) A randomized, doule-blind clinical trial of vaginal acidification versus placebo for the treatment of symptomatic bacterial vaginosis. Sex Transm Dis 31:236-238
26. Fiorilli A, Molteni B, Milani M (2005) Successful treatment of bacterial vaginosis with a polycarbophil-Carbopol acidic vaginal gel: results from a randomised double-blind, placebo-controlled trial. Eur J Obstet Gynecol Reprod Biol 120(2):202-205