Using yeast to uncover the regulation of protein kinase Cδ by ceramide

FEMS Yeast Research

Volumn 13, Issue 7, 2013, Pages 700-705

  Bessa, Cláudia ^a   Pereira, Clara ^a   Leão, Mariana ^a   Maciel, Cláudia ^a   Gomes, Sara ^a   Gonçalves, Jorge ^a   Corte Real, Manuela ^b   Costa, Vítor ^a,c   Saraiva, Lucília ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF MINHO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Ceramide; Protein kinase C ; Saccharomyces cerevisiae

Indexed keywords

2,6 DIAMINO N [[1 (1 OXOTRIDECYL) 2 PIPERIDYL]METHYL]HEXANAMIDE; CERAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C ZETA; SPHINGOLIPID;

ARTICLE; ENZYME ACTIVITY; ENZYME REGULATION; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HYDROLYSIS; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

CERAMIDE; PROTEIN KINASE CΔ; SACCHAROMYCES CEREVISIAE;

CELL CYCLE; CERAMIDES; ENZYME INHIBITORS; PROTEIN ISOFORMS; PROTEIN KINASE C; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 84886089759     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/1567-1364.12069     Document Type: Article

References (15)

1. Coutinho I, Pereira G, Leão M, Gonçalves J, Côrte-Real M & Saraiva L (2009a) Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system. FEBS Lett 583: 3582-3588.
2. Coutinho I, Pereira G, Simões MF, Côrte-Real M, Gonçalves J & Saraiva L (2009b) Selective activation of protein kinase C-δ and -ε by 6, 11, 12, 14-tetrahydroxy-abieta-5, 8, 11, 13-tetraene-7-one (coleon U). Biochem Pharmacol 78: 449-459.
3. Coutinho I, Pereira C, Pereira G, Gonçalves J, Côrte-Real M & Saraiva L (2011) Distinct regulation of p53-mediated apoptosis by protein kinase C alpha, delta, epsilon and zeta: evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Exp Cell Res 317: 1147-1158.
4. Huwiler A, Fabbro D & Pfeilschifter J (1998) Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells. Biochemistry 37: 14556-14562.
5. Kajimoto T, Ohmori S, Shirai Y, Sakai N & Saito N (2001) Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells. Mol Cell Biol 21: 1769-1783.
6. Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U & Saito N (2004) Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex. J Biol Chem 279: 12668-12676.
7. Lee J, Hannun Y & Obeid L (1996) Ceramide inactivates cellular protein kinase C alpha. J Biol Chem 271: 13169-13174.
8. Matmati N & Hannun Y (2008) Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases. J Lipid Res 49: 922-928.
9. Parissenti AM & Riedel H (2003) Yeast as a host to screen for modulators and regulatory regions of mammalian protein kinase C isoforms. Methods Mol Biol 233: 491-516.
10. Pereira C, Leão M, Soares J, Bessa C & Saraiva L (2012) New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems. Curr Pharm Des 18: 4223-4235.
11. Rego A, Costa M, Chaves S, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V & Côrte-Real M (2012) Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS ONE 7: e48571.
12. Saddoughi S, Song P & Ogretmen B (2008) Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem 49: 413-440.
13. Saraiva L, Fresco P, Pinto E & Gonçalves J (2003) Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. J Enzyme Inhib Med Chem 18: 475-483.
14. Saraiva L, Silva RD, Pereira G, Gonçalves J & Côrte-Real M (2006) Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms. J Cell Sci 119: 3171-3181.
15. Silva R, Saraiva L, Coutinho I, Gonçalves J & Côrte-Real M (2012) Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms. Curr Pharm Des 18: 2492-2500.