Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-α, -βI, δ, -η and ζ

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 6, 2003, Pages 475-483

  Saraiva, Lucílla ^a   Fresco, Paula ^a   Pinto, Eugénia ^a   Gonçalves, Jorge ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

PKC inhibitors; PKC isoforms; Protein kinase C; Yeast phenotypic assay

Indexed keywords

2,6 DIAMINO N [[1 (1 OXOTRIDECYL) 2 PIPERIDYL]METHYL]HEXANAMIDE; 3 [8 [(DIMETHYLAMINO)METHYL] 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YL] 4 (1 METHYL 1H INDOL 3 YL) 1H PYRROLE 2,5 DIONE; CHELERYTHRINE; ISOENZYME; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C ZETA; ROTTLERIN; SPHINGOSINE; TAMOXIFEN;

ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME REGULATION; FUNGUS CULTURE; FUNGUS GROWTH; GROWTH INHIBITION; IMMUNOBLOTTING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; YEAST;

ACETOPHENONES; ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; BENZOPYRANS; CATALYSIS; ENZYME INHIBITORS; ESCHERICHIA COLI; INDOLES; ISOENZYMES; PHENANTHRIDINES; PIPERIDINES; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; PYRROLES; SACCHAROMYCES CEREVISIAE; SPHINGOSINE; TAMOXIFEN; YEASTS;

FUNGI; MAMMALIA;

EID: 0344739767     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360310001603158     Document Type: Article

References (34)

1. Musashi, M., Ota, S. and Shiroshita, N. (2000) Int. J. Hematol. 72, 12.
2. Barry, O.P. and Kazanietz, M.G. (2001) Curr. Pharm. Des. 7, 1725.
3. Webb, B.L., Hirst, S.J. and Giembycz, M.A. (2000) Br. J. Pharmacol. 130, 1433.
4. Hofmann, J. (2001) Rev. Physiol. Biochem. Pharmacol. 142, 1.
5. Watters, D.J. and Parsons, P.G. (1999) Biochem. Pharmacol. 58, 383.
6. Bradshaw, D., Hill, C.H., Nixon, J.S. and Wilkinson, S.E. (1993) Agents Actions 38, 135.
7. da Rocha, A.B., Mans, D.R.A., Regner, A. and Schwartsmann, G. (2002) Oncologist 7, 17.
8. Hofmann, J. (1997) FASEB J. 11, 649.
9. Way, K.J., Chou, E. and King, G.L. (2000) TIPS 21, 181.
10. Herbert, J.M., Augereau, J.M., Gleye, J. and Maffrand, J.P. (1990) Biochem. Biophys. Res. Commun. 172, 993.
11. Sullivan, J.P., Connor, J.R., Tiffany, C., Shearer, B.G. and Burch, R.M. (1991) FEBS Lett. 285, 120.
12. Sullivan, J.P., Connor, J.R., Shearer, B.G. and Burch, R.M. (1991) Agents Actions 34, 142.
13. Sullivan, J.P., Connor, J.R., Shearer, B.G. and Burch, R.M. (1992) Mol. Pharmacol. 41, 38.
14. Birchall, A.M., Bishop, J., Bradshaw, D., Cline, A., Coffey, J., Elliott, L.H., Gibson, V.M., Greenham, A., Hallam, T.J., Harris, W., Hill, C.H., Hutchings, A., Lamont, A.G., Lawton, G., Lewis, E.J., Maw, A., Nixon, J.S., Pole, D., Wadsworth, J. and Wilkinson, S.E. (1994) J. Pharmacol. Exp. Ther. 268, 922.
15. Wilkinson, S.E., Parker, P.J. and Nixon, J.S. (1993) Biochem. J. 294, 335.
16. O'Brian, C.A., Liskamp, R.M., Solomon, D.H. and Weinstein, I.B. (1985) Cancer Res. 45, 2462.
17. O'Brian, C.A., Liskamp, R.M., Solomon, D.H. and Weinstein, I.B. (1986) J. Natl Cancer Inst. 76, 1243.
18. Horgan, K., Cooke, E., Hallett, M.B. and Mansel, R.E. (1986) Biochem. Pharmacol. 35, 4463.
19. Rowlands, M.G., Budworth, J., Jarman, M., Hardcastle, I.R., McCague, R. and Gescher, A. (1995) Biochem. Pharmacol. 50, 723.
20. Gundimeda, U., Chen, Z.-H. and Gopalakrishna, R. (1996) J. Biol. Chem. 271, 13504.
21. Gschwendt, M., Muller, H.J., Kielbassa, K., Zang, R., Kittstein, W., Rincke, G. and Marks, F. (1994) Biochem. Biophys. Res. Commun. 199, 93.
22. Hannun, Y.A., Loomis, C.R., Merrill, A.H., Jr. and Bell, R.M. (1986) J. Biol. Chem. 261, 12604.
23. Hannun, Y.A. and Bell, R.M. (1989) Clin. Chim. Acta 185, 333.
24. Keenan, C., Goode, N. and Pears, C. (1997) FEBS Lett. 415, 101.
25. Riedel, H., Hansen, H., Parissenti, A.M., Su, L., Shieh, H.-L. and Zhu, J. (1993) J. Cell. Biochem. 52, 320.
26. Shieh, H.-L., Hansen, H., Zhu, J. and Riedel, H. (1995) Mol. Carcinog. 12, 166.
27. Keenan, C., Goode, N. and Pears, C. (1997) Biochem. Soc. Trans. 25, S591.
28. Ito, H., Fukuda, Y., Murata, K. and Kimura, A. (1983) J. Bacteriol. 153, 163.
29. Ways, D.K., Cook, P.P., Webster, C. and Parker, P.J. (1992) J. Biol. Chem. 267, 4799.
30. Nakanishi, H. and Exton, J.H. (1992) J. Biol. Chem. 267, 16347.
31. Hashimoto, Y., Osada, S., Ohno, S. and Kuroki, T. (1992) Tohoku J. Exp. Med. 168, 275.
32. Lippman, M., Bolan, G. and Huff, K. (1976) Cancer Res. 36, 4610.
33. Coezy, E., Borgna, J.L. and Rochefort, H. (1982) Cancer Res. 42, 317.
34. Burshell, A., Stathis, P.A., Do, Y., Miller, S.C. and Feldman, D. (1984) J. Biol. Chem. 259, 3450.