Metabolic engineering of monoclonal antibody carbohydrates for antibody-drug conjugation

Bioconjugate Chemistry

Volumn 24, Issue 10, 2013, Pages 1650-1655

  Okeley, Nicole M ^a   Toki, Brian E ^a   Zhang, Xinqun ^a   Jeffrey, Scott C ^a   Burke, Patrick J ^a   Alley, Stephen C ^a   Senter, Peter D ^a  

^a SEATTLE GENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXICITY; METABOLIC ENGINEERING; MONOCLONAL ANTIBODIES; SULFUR COMPOUNDS;

ANTIBODY DRUGS; ANTIBODY-DRUG CONJUGATES; CELLULAR CYTOTOXICITY; CYTOTOXIC ACTIVITIES; FUCOSYLTRANSFERASES; MALEIMIDES; N-LINKED GLYCAN STRUCTURES; NATURAL SUGARS;

CARBOHYDRATES;

CARBOHYDRATE; DISULFIDE; FUCOSE; FUCOSYLTRANSFERASE; GLYCAN; MALEIMIDE; MONOCLONAL ANTIBODY; THIOL GROUP;

ANTIBODY CONJUGATION; ARTICLE; CARBOHYDRATE ANALYSIS; CELL MEDIATED CYTOTOXICITY; CHEMICAL STRUCTURE; CONJUGATION; CYTOTOXICITY; DRUG CONJUGATION; METABOLIC ENGINEERING; MOLECULAR LIBRARY;

ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CARBOHYDRATES; CELL LINE; DISULFIDES; FUCOSE; HUMANS; IMMUNOCONJUGATES; METABOLIC ENGINEERING;

EID: 84886075258     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc4002695     Document Type: Article

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