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Volumn , Issue , 2011, Pages 317-328

Discovery of Cyclophilin Inhibitor NIM811 as a Novel Therapeutic Agent for HCV

Author keywords

HCV inhibitory activities, cyclosporin analogs and cyclophilin binding affinities; NIM811, and HCV patient care NIM811 and IFN , in vitro using HCV replicon system; Other HCV inhibitors, cyclophilin inhibitor NIM811 discovery novel therapeutic agent for HCV

Indexed keywords


EID: 84885972070     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470929353.ch22     Document Type: Chapter
Times cited : (3)

References (58)
  • 1
    • 22244464562 scopus 로고    scopus 로고
    • The cyclophilins
    • Wang, P.; Heitman, J. The cyclophilins. Genome Biol. 2005, 6(7), 226.
    • (2005) Genome Biol. , vol.6 , Issue.7 , pp. 226
    • Wang, P.1    Heitman, J.2
  • 2
    • 0021159379 scopus 로고
    • Cyclophilin: a specific cytosolic binding protein for cyclosporin A
    • Handschumacher, R. E.; Harding, M. W.; Rice, J.; Drugge, R. J.; Speicher, D.W. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984, 226(4674), 544-547.
    • (1984) Science. , vol.226 , Issue.4674 , pp. 544-547
    • Handschumacher, R.E.1    Harding, M.W.2    Rice, J.3    Drugge, R.J.4    Speicher, D.W.5
  • 3
    • 0021668676 scopus 로고
    • Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides
    • Fischer, G.; Bang, H.; Mech, C. Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides.] Biomed. Biochim. Acta 1984, 43(10), 1101-1111.
    • (1984) Biomed. Biochim. Acta. , vol.43 , Issue.10 , pp. 1101-1111
    • Fischer, G.1    Bang, H.2    Mech, C.3
  • 4
    • 0024959449 scopus 로고
    • Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
    • Fischer, G.; Wittmann-Liebold, B.; Lang, K.; Kiefhaber, T.; Schmid, F. X. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 1989, 337(6206), 476-478.
    • (1989) Nature. , vol.337 , Issue.6206 , pp. 476-478
    • Fischer, G.1    Wittmann-Liebold, B.2    Lang, K.3    Kiefhaber, T.4    Schmid, F.X.5
  • 5
    • 0024959451 scopus 로고
    • Peptidyl-prolyl cistrans isomerase is the cyclosporin A-binding protein cyclophilin
    • Takahashi, N.; Hayano, T.; Suzuki, M. Peptidyl-prolyl cistrans isomerase is the cyclosporin A-binding protein cyclophilin. Nature 1989, 337(6206), 473-475.
    • (1989) Nature. , vol.337 , Issue.6206 , pp. 473-475
    • Takahashi, N.1    Hayano, T.2    Suzuki, M.3
  • 6
    • 0027071803 scopus 로고
    • Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporinAbinding and calcineurin inhibition
    • Zydowsky, L. D.; Etzkorn, F. A.; Chang, H. Y.; Ferguson, S. B.; Stolz, L. A.; Ho, S. I.; Walsh, C. T. Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporinAbinding and calcineurin inhibition. Protein Sci. 1992, 1(9), 1092-1099.
    • (1992) Protein Sci. , vol.1 , Issue.9 , pp. 1092-1099
    • Zydowsky, L.D.1    Etzkorn, F.A.2    Chang, H.Y.3    Ferguson, S.B.4    Stolz, L.A.5    Ho, S.I.6    Walsh, C.T.7
  • 7
    • 0038102952 scopus 로고    scopus 로고
    • Combined interferon alpha2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial
    • Inoue, K.; Sekiyama, K.; Yamada, M.; Watanabe, T.; Yasuda, H.;Yoshiba,M. Combined interferon alpha2b and cyclosporin A in the treatment of chronic hepatitis C: controlled trial. J. Gastroenterol. 2003, 38(6), 567-572.
    • (2003) J. Gastroenterol. , vol.38 , Issue.6 , pp. 567-572
    • Inoue, K.1    Sekiyama, K.2    Yamada, M.3    Watanabe, T.4    Yasuda, H.5    Yoshiba, M.6
  • 9
    • 0028965266 scopus 로고
    • Mode of action of SDZ NIM811, a nonimmunosuppressive cyclosporinAanalogwith activity against human immunodeficiency virus (HIV) type 1 interference with HIV protein-cyclophilin A interactions
    • Billich, A.; Hammerschmid, F.; Peichl, P.;Wenger, R.; Zenke, G.; Quesniaux, V.; Rosenwirth, B. Mode of action of SDZ NIM811, a nonimmunosuppressive cyclosporinAanalogwith activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions. J. Virol. 1995, 69(4), 2451-2461.
    • (1995) J. Virol. , vol.69 , Issue.4 , pp. 2451-2461
    • Billich, A.1    Hammerschmid, F.2    Peichl, P.3    Wenger, R.4    Zenke, G.5    Quesniaux, V.6    Rosenwirth, B.7
  • 10
    • 0027947038 scopus 로고
    • Cyclosporin A inhibits vaccinia virus replication in vitro
    • Damaso, C. R.; Keller, S. J. Cyclosporin A inhibits vaccinia virus replication in vitro. Arch. Virol. 1994, 134(3-4), 303-319.
    • (1994) Arch. Virol. , vol.134 , Issue.3-4 , pp. 303-319
    • Damaso, C.R.1    Keller, S.J.2
  • 11
    • 0026738697 scopus 로고
    • Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506
    • Karpas, A.; Lowdell, M.; Jacobson, S. K.; Hill, F. Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506. Proc. Natl. Acad. Sci. USA 1992, 89(17), 8351-8355.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.17 , pp. 8351-8355
    • Karpas, A.1    Lowdell, M.2    Jacobson, S.K.3    Hill, F.4
  • 13
    • 0038496844 scopus 로고    scopus 로고
    • Requirement for cyclophilin A for the replication of vesicular stomatitis virus New Jersey serotype
    • Bose, S.; Mathur, M.; Bates, P.; Joshi, N.; Banerjee, A. K. Requirement for cyclophilin A for the replication of vesicular stomatitis virus New Jersey serotype. J. Gen. Virol. 2003, 84(Pt. 7), 1687-1699.
    • (2003) J. Gen. Virol. , vol.84 , Issue.PART 7 , pp. 1687-1699
    • Bose, S.1    Mathur, M.2    Bates, P.3    Joshi, N.4    Banerjee, A.K.5
  • 14
    • 0037744950 scopus 로고    scopus 로고
    • Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication
    • Bouchard, M. J.; Puro, R. J.; Wang, L.; Schneider, R. J. Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication. J. Virol. 2003, 77(14), 7713-7719.
    • (2003) J. Virol. , vol.77 , Issue.14 , pp. 7713-7719
    • Bouchard, M.J.1    Puro, R.J.2    Wang, L.3    Schneider, R.J.4
  • 15
    • 0142182744 scopus 로고    scopus 로고
    • Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    • Watashi, K.; Hijikata, M.; Hosaka, M.; Yamaji, M.; Shimotohno, K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003, 38(5), 1282-1288.
    • (2003) Hepatology. , vol.38 , Issue.5 , pp. 1282-1288
    • Watashi, K.1    Hijikata, M.2    Hosaka, M.3    Yamaji, M.4    Shimotohno, K.5
  • 17
    • 33748687426 scopus 로고    scopus 로고
    • NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon
    • Ma, S.; Boerner, J. E.; TiongYip, C.; Weidmann, B.; Ryder, N. S.; Cooreman, M. P.; Lin, K. NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha interferon. Antimicrob. Agents Chemother. 2006, 50(9), 2976-2982.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , Issue.9 , pp. 2976-2982
    • Ma, S.1    Boerner, J.E.2    TiongYip, C.3    Weidmann, B.4    Ryder, N.S.5    Cooreman, M.P.6    Lin, K.7
  • 19
    • 61449166638 scopus 로고    scopus 로고
    • Cyclophilin B stimulates RNAsynthesis by theHCVRNAdependentRNApolymerase
    • Heck, J. A.; Meng, X.; Frick, D. N. Cyclophilin B stimulates RNAsynthesis by theHCVRNAdependentRNApolymerase. Biochem. Pharmacol. 2009, 77(7), 1173-1180.
    • (2009) Biochem. Pharmacol. , vol.77 , Issue.7 , pp. 1173-1180
    • Heck, J.A.1    Meng, X.2    Frick, D.N.3
  • 20
    • 43949123575 scopus 로고    scopus 로고
    • Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro
    • Yang, F.; Robotham, J. M.; Nelson, H. B.; Irsigler, A.; Kenworthy, R.; Tang, H. Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. J. Virol. 2008, 82(11), 5269-5278.
    • (2008) J. Virol. , vol.82 , Issue.11 , pp. 5269-5278
    • Yang, F.1    Robotham, J.M.2    Nelson, H.B.3    Irsigler, A.4    Kenworthy, R.5    Tang, H.6
  • 22
    • 67449093865 scopus 로고    scopus 로고
    • A Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the HCV replication complex
    • Liu, Z.; Yang, F.; Robotham, J. M.; Tang, H. A Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the HCV replication complex. J. Virol. 2009, 83(13), 6554-6555.
    • (2009) J. Virol. , vol.83 , Issue.13 , pp. 6554-6555
    • Liu, Z.1    Yang, F.2    Robotham, J.M.3    Tang, H.4
  • 23
    • 34249817897 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro
    • Robida, J. M.; Nelson, H. B.; Liu, Z.; Tang, H. Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro. J. Virol. 2007, 81(11), 5829-5840.
    • (2007) J. Virol. , vol.81 , Issue.11 , pp. 5829-5840
    • Robida, J.M.1    Nelson, H.B.2    Liu, Z.3    Tang, H.4
  • 24
    • 36349034692 scopus 로고    scopus 로고
    • Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B
    • Fernandes, F.; Poole, D. S.;Hoover, S.;Middleton, R.;Andrei, A. C.; Gerstner, J.; Striker, R. Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B. Hepatology 2007, 46(4), 1026-1033.
    • (2007) Hepatology. , vol.46 , Issue.4 , pp. 1026-1033
    • Fernandes, F.1    Poole, D.S.2    Hoover, S.3    Middleton, R.4    Andrei, A.C.5    Gerstner, J.6    Striker, R.7
  • 25
    • 67649412015 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B
    • Hanoulle, X.; Badillo, A.; Wieruszeski, J. M.; Verdegem, D.; Landrieu, I.; Bartenschlager, R.; Penin, F.; Lippens,G.Hepatitis C virus NS5A protein is a substrate for the peptidyl-prolyl cis/trans isomerase activity of cyclophilins A and B. J. Biol. Chem. 2009, 284(20), 13589-13601.
    • (2009) J. Biol. Chem. , vol.284 , Issue.20 , pp. 13589-13601
    • Hanoulle, X.1    Badillo, A.2    Wieruszeski, J.M.3    Verdegem, D.4    Landrieu, I.5    Bartenschlager, R.6    Penin, F.7    Lippens, G.8
  • 28
    • 0028136557 scopus 로고
    • [Melle( [4])]cyclosporin, a novel natural cyclosporine with anti-HIV activity: structural elucidation, biosynthesis
    • Traber, R.; Kobel, H.; Loosli, H. R.; Senn, H.; Rosenwirth, B.; Lawen, A. [Melle( [4])]cyclosporin, a novel natural cyclosporine with anti-HIV activity: structural elucidation, biosynthesis. Antiviral Chem. Chemother. 1994, 5(5), 331-339.
    • (1994) Antiviral Chem. Chemother. , vol.5 , Issue.5 , pp. 331-339
    • Traber, R.1    Kobel, H.2    Loosli, H.R.3    Senn, H.4    Rosenwirth, B.5    Lawen, A.6
  • 29
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporinAand FKBP-FK506 complexes
    • Liu, J.; Farmer, J. D., Jr.; Lane, W. S.; Friedman, J.; Weissman, I.; Schreiber, S. L. Calcineurin is a common target of cyclophilin-cyclosporinAand FKBP-FK506 complexes. Cell 1991, 66(4), 807-815.
    • (1991) Cell. , vol.66 , Issue.4 , pp. 807-815
    • Liu, J.1    Farmer Jr., J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 30
    • 0027491776 scopus 로고
    • The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
    • Jain, J.; McCaffrey, P. G.;Miner, Z.;Kerppola, T. K.; Lambert, J. N.; Verdine, G. L.; Curran, T.; Rao, A. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 1993, 365(6444), 352-355.
    • (1993) Nature. , vol.365 , Issue.6444 , pp. 352-355
    • Jain, J.1    McCaffrey, P.G.2    Miner, Z.3    Kerppola, T.K.4    Lambert, J.N.5    Verdine, G.L.6    Curran, T.7    Rao, A.8
  • 32
    • 0037126026 scopus 로고    scopus 로고
    • Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
    • Huai, Q.; Kim, H. Y.; Liu, Y.; Zhao, Y.; Mondragon, A.; Liu, J. O.; Ke, H. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proc. Natl. Acad. Sci. USA 2002, 99(19), 12037-12042.
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , Issue.19 , pp. 12037-12042
    • Huai, Q.1    Kim, H.Y.2    Liu, Y.3    Zhao, Y.4    Mondragon, A.5    Liu, J.O.6    Ke, H.7
  • 33
    • 0037108767 scopus 로고    scopus 로고
    • Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
    • Jin, L.; Harrison, S. C. Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc. Natl. Acad. Sci. USA 2002, 99(21), 13522-13526.
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , Issue.21 , pp. 13522-13526
    • Jin, L.1    Harrison, S.C.2
  • 34
    • 0032561136 scopus 로고    scopus 로고
    • Xray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A
    • Kallen, J.; Mikol, V.; Taylor, P.; Walkinshaw, M. D. Xray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A. J. Mol. Biol. 1998, 283(2), 435-449.
    • (1998) J. Mol. Biol. , vol.283 , Issue.2 , pp. 435-449
    • Kallen, J.1    Mikol, V.2    Taylor, P.3    Walkinshaw, M.D.4
  • 37
    • 0027940713 scopus 로고
    • Specific incorporation of cyclophilin A into HIV-1 virions
    • Franke, E. K.; Yuan, H. E.; Luban, J. Specific incorporation of cyclophilin A into HIV-1 virions. Nature 1994, 372(6504), 359-362.
    • (1994) Nature. , vol.372 , Issue.6504 , pp. 359-362
    • Franke, E.K.1    Yuan, H.E.2    Luban, J.3
  • 38
    • 0027207885 scopus 로고
    • Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B
    • Luban, J.; Bossolt, K. L.; Franke, E. K.; Kalpana, G. V.; Goff, S. P. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 1993, 73(6), 1067-1078.
    • (1993) Cell. , vol.73 , Issue.6 , pp. 1067-1078
    • Luban, J.1    Bossolt, K.L.2    Franke, E.K.3    Kalpana, G.V.4    Goff, S.P.5
  • 40
    • 0030932480 scopus 로고    scopus 로고
    • The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells
    • Mlynar, E.; Bevec, D.; Billich, A.; Rosenwirth, B.; Steinkasserer, A. The non-immunosuppressive cyclosporin A analogue SDZ NIM 811 inhibits cyclophilin A incorporation into virions and virus replication in human immunodeficiency virus type 1-infected primary and growth-arrested T cells. J. Gen. Virol. 1997, 78(Pt. 4), 825-835.
    • (1997) J. Gen. Virol. , vol.78 , Issue.PART 4 , pp. 825-835
    • Mlynar, E.1    Bevec, D.2    Billich, A.3    Rosenwirth, B.4    Steinkasserer, A.5
  • 42
    • 0024993530 scopus 로고
    • A three-dimensional model to analyze drug-drug interactions
    • Prichard, M. N.; Shipman, C., Jr. A three-dimensional model to analyze drug-drug interactions. Antiviral Res. 1990, 14( 4-5), 181-205.
    • (1990) Antiviral Res. , vol.14 , Issue.4-5 , pp. 181-205
    • Prichard, M.N.1    Shipman Jr., C.2
  • 48
    • 50949096105 scopus 로고    scopus 로고
    • Combinations of cyclophilin inhibitor NIM811 with hepatitis C virus NS3-4A protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance
    • Mathy, J. E.; Ma, S.; Compton, T.; Lin, K. Combinations of cyclophilin inhibitor NIM811 with hepatitis C virus NS3-4A protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance. Antimicrob. Agents Chemother. 2008, 52(9), 3267-3275.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , Issue.9 , pp. 3267-3275
    • Mathy, J.E.1    Ma, S.2    Compton, T.3    Lin, K.4
  • 51
    • 0026766758 scopus 로고
    • Cyclosporin synthetase is a 1.4 MDa multienzyme polypeptide: re-evaluation of the molecular mass of various peptide synthetases
    • Schmidt, B.; Riesner, D.; Lawen, A.; Kleinkauf, H. Cyclosporin synthetase is a 1.4 MDa multienzyme polypeptide: re-evaluation of the molecular mass of various peptide synthetases. FEBS Lett. 1992, 307(3), 355-360.
    • (1992) FEBS Lett. , vol.307 , Issue.3 , pp. 355-360
    • Schmidt, B.1    Riesner, D.2    Lawen, A.3    Kleinkauf, H.4
  • 52
    • 0025193843 scopus 로고
    • Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described
    • Lawen,A.; Zocher, R. Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described. J. Biol. Chem. 1990, 265(19), 11355-11360.
    • (1990) J. Biol. Chem. , vol.265 , Issue.19 , pp. 11355-11360
    • Lawen, A.1    Zocher, R.2
  • 53
    • 0028284699 scopus 로고
    • The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame
    • Weber, G.; Schorgendorfer, K.; Schneider-Scherzer, E.; Leitner, E. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr. Genet. 1994, 26(2), 120-125.
    • (1994) Curr. Genet. , vol.26 , Issue.2 , pp. 120-125
    • Weber, G.1    Schorgendorfer, K.2    Schneider-Scherzer, E.3    Leitner, E.4
  • 55


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