Is it time to rethink how neuropsychological tests are used to diagnose mild forms of HIV-associated neurocognitive disorders? Impact of false-positive rates on prevalence and power

Neuroepidemiology

Volumn 41, Issue 3-4, 2013, Pages 208-216

  Meyer, Ana Claire L ^a,c   John Boscardin, W ^b   Kwasa, Judith K ^c   Price, Richard W ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

Africa; Dementia; HIV; Power; Prevalence

Indexed keywords

ARTICLE; COGNITION; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; HIV ASSOCIATED DEMENTIA; HUMAN; KENYA; MAJOR CLINICAL STUDY; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TEST; PREVALENCE; SCORING SYSTEM; ADULT; DISEASE CLASSIFICATION;

COGNITION DISORDERS; FALSE POSITIVE REACTIONS; HIV INFECTIONS; HUMANS; NEUROPSYCHOLOGICAL TESTS;

EID: 84885962336     PISSN: 02515350     EISSN: 14230208     Source Type: Journal    
DOI: 10.1159/000354629     Document Type: Article

References (24)

1. McArthur JC, Brew B: HIV-associated neurocognitive disorders: is there a hidden epidemic? AIDS 2010; 24: 1367-1370.
2. Torti C, Foca E, Cesana B, Lescure F: Asymptomatic neurocognitive disorders in patients infected with HIV: fact or fiction. BMC Med 2011; 9: 138.
3. Antinori A, Arendt G, Becker J, et al: Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007; 69: 1789-1799.
4. Cherner M, Cysique L, Heaton RK, et al: Neuropathologic confirmation of definitional criteria for human immunodeficiency virus-associated neurocognitive disorders. J Neurovirol 2007; 13: 23-28.
5. Cherner M, Masliah E, Ellis RJ, et al: Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis. Neurology 2002; 59: 1563-1567.
6. Cysique L, Franklin D, Abramson I, et al: Normative data and validation of a regression based summary score for assessing meaningful neuropsychological change. J Clin Exp Neuropsychol 2011; 33: 505-522.
7. Gisslen M, Price RW, Nilsson S: The definition of HIV-associated neurocognitive disorders: are we overestimating the prevalence? BMC Infect Dis 2011; 11: 356.
8. Heaton R, Chelune G, Talley J, Kay G, Curtiss G: Revised Comprehensive Norms for an Expanded Halstead-Reitan Battery: Demographically Adjusted Neuropsychological Norms for African American and Caucasian Adults. Lutz, Psychological Assessment Resources, 2004.
9. Sainani K: The problem of multiple testing. PM R 2009; 1: 1098-1103.
10. Hofler M: The effect of misclassification on the estimation of association: a review. Int J Methods Psychiatr Res 2005; 14: 92-101.
11. Jurek A, Greenland S, Maldonado G, Church T: Proper interpretation of non-differential misclassification effects: expectation vs observations. Int J Epidemiol 2005; 34: 680-687.
12. Bross I: Misclassification in 2 × 2 tables. Int Biom Soc 1954; 10: 478-486.
13. Heaton RK, Clifford DB, Franklin DR, et al: HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 2010; 75: 2087-2096.
14. Spreen O, Strauss E: Compendium of Neuropsychological Tests. New York, Oxford University Press, 1998.
15. Strauss E, Sherman E, Spreen O: A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary, ed 3. New York, Oxford University Press, 2006.
16. Flegal K, Brownie C, Haas J: The effects of exposure misclassification on estimates of relative risk. Am J Epidemiol 1986; 123: 736-751.
17. Ward A, Arrighi H, Michels S, Cedarbaum J: Mild cognitive impairment: disparity of incidence and prevalence estimates. Alzheimers Dement 2012; 8: 14-21.
18. Albert M, DeKosky S, Dickson D, et al: The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute of Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 270-279.
19. Mayeux R, Reitz C, Brickman A, et al: Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment. Part 1. Alzheimers Dement 2011; 7: 15-34.
20. Sabbagh M, Cooper K, DeLange J, et al: Functional, global and cognitive decline correlates to accumulation of Alzheimer's pathology in MCI and AD. Curr Alzheimer Res 2010; 7: 280-286.
21. Palmer B, Boone K, Lesser I, Wohl M: Base rates of 'impaired' neuropsychological test performance among healthy older adults. Arch Clin Neuropsychol 1988; 13: 503-511.
22. Brooks B, Iverson G, Feldman H, Holdnack J: Minimizing misdiagnosis: psychometric criteria for possible or probable memory impairment. Dement Geriatr Cogn Disord 2009; 27: 439-450.
23. Fletcher R, Fletcher S: Clinical Epidemiology: The Essentials, ed 4. Baltimore, Lippincott, Williams & Wilkins, 2005, pp 40-43.
24. Carey C, Woods S, Gonzalez R, et al: Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. J Clin Exp Neuropsychol 2004; 26: 307-319.