ST2 regulates allergic airway inflammation and T-Cell polarization in epicutaneously sensitized mice

Journal of Investigative Dermatology

Volumn 133, Issue 11, 2013, Pages 2522-2529

  Savinko, Terhi ^a   Karisola, Piia ^a   Lehtimäki, Sari ^a   Lappeteläinen, Anna Mari ^a   Haapakoski, Rita ^a   Wolff, Henrik ^a   Lauerma, Antti ^b   Alenius, Harri ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 33; INTERLEUKIN 33 RECEPTOR; INTERLEUKIN RECEPTOR; OVALBUMIN; ST2 PROTEIN; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATITIS; EOSINOPHIL COUNT; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROVOCATION TEST; SENSITIZATION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE POLARIZATION; TH2 CELL; TISSUE LEVEL; WILD TYPE;

EID: 84885947667     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.195     Document Type: Article

References (37)

1. Akei HS, Brandt EB, Mishra A et al. (2006) Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol 118:62-9 (Pubitemid 43946489)
2. Ali S, Mohs A, Thomas M et al. (2011) The dual function cytokine IL-33 interacts with the transcription factor NF-{kappa}B to dampen NF-{kappa}B-stimulated gene transcription. J Immunol 187:1609-16
3. Allakhverdi Z, Smith DE, Comeau MR et al. (2007) Cutting edge: The ST2 ligand IL-33 potently activates and drives maturation of human mast cells. J Immunol 179:2051-4
4. Blom L, Poulsen BC, Jensen BM et al. (2010) IL-33 induces IL-9 production in human CD4\+ T cells and basophils. PloS One 6:e21695
5. Boguniewicz M, Leung DY (2011) Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev 242:233-46
6. Carmi-Levy I, Homey B, Soumelis V (2011) A modular view of cytokine networks in atopic dermatitis. Clin Rev Allergy Immunol 41:245-53
7. Cherry WB, Yoon J, Bartemes KR et al. (2008) A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol 121:1484-90 (Pubitemid 351787349)
8. Coyle AJ, Lloyd C, Tian J et al. (1999) Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med 190:895-902 (Pubitemid 29480818)
9. Hoshino K, Kashiwamura S, Kuribayashi K et al. (1999) The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med 190:1541-8
10. Kim HY, Chang YJ, Subramanian S et al. (2011) Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. J Allergy Clin Immunol 129:216-27. e1-6
11. Kinoshita H, Takai T, Le TA et al. (2009) Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol 123:179-86
12. Kulig M, Bergmann R, Klettke U et al. (1999) Natural course of sensitization to food and inhalant allergens during the first 6 years of life. J Allergy Clin Immunol 103:1173-9 (Pubitemid 29343086)
13. Kurowska-Stolarska M, Kewin P, Murphy G et al. (2008) IL-33 induces antigenspecific IL-5\+ T cells and promotes allergic-induced airway inflammation independent of IL-4. J Immunol 181:4780-90
14. Lecart S, Lecointe N, Subramaniam A et al. (2002) Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur J Immunol 32:2979-87 (Pubitemid 35238191)
15. Lehto M, Haapakoski R, Wolff H et al. (2005) Cutaneous, but not airway, latex exposure induces allergic lung inflammation and airway hyperreactivity in mice. J Invest Dermatol 125:962-8
16. Lehto M, Savinko T, Wolff H et al. (2010) A murine model of epicutaneous protein sensitization is useful to study efficacies of topical drugs in atopic dermatitis. Int Immunopharmacol 10:377-84
17. Liew FY, Pitman NI, McInnes IB (2010) Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev 10:103-10
18. Lohning M, Stroehmann A, Coyle AJ et al. (1998) T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA 95:6930-5 (Pubitemid 28278084)
19. Mangan NE, Dasvarma A, McKenzie AN et al. (2007) T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. Eur J Immunol 37:1302-12 (Pubitemid 46925314)
20. Michie CA, Davis T (1996) Atopic dermatitis and staphylococcal superantigens. Lancet 347:324
21. Moffatt MF, Gut IG, Demenais F et al. (2010) A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363:1211-21
22. Ober C, Yao TC (2011) The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 242:10-30
23. Prefontaine D, Lajoie-Kadoch S, Foley S et al. (2009) Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol 183:5094-103
24. Prefontaine D, Nadigel J, Chouiali F et al. (2010) Increased IL-33 expression by epithelial cells in bronchial asthma. J Allergy Clin Immunol 125:752-4
25. Rank MA, Kobayashi T, Kozaki H et al. (2009) IL-33-activated dendritic cells induce an atypical TH2-type response. J Allergy Clin Immunol 123:1047-54
26. Savinko T, Lauerma A, Lehtimaki S et al. (2005) Topical superantigen exposure induces epidermal accumulation of CD8\+ T cells, a mixed Th1/Th2-type dermatitis and vigorous production of IgE antibodies in the murine model of atopic dermatitis. J Immunol 175:8320-6 (Pubitemid 41798398)
27. Savinko T, Matikainen S, Saarialho-Kere U et al. (2012) IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol 132:1392-400
28. Schmitz J, Owyang A, Oldham E et al. (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23:479-90 (Pubitemid 41587888)
29. Senn KA, McCoy KD, Maloy KJ et al. (2000) T1-deficient and T1-Fctransgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis. Eur J Immunol 30:1929-38 (Pubitemid 30456189)
30. Shimizu M, Matsuda A, Yanagisawa K et al. (2005) Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum Mol Genet 14:2919-27 (Pubitemid 41418796)
31. Smith DE (2009) IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma. Clin Exp Allergy 40:200-8
32. Spergel JM, Mizoguchi E, Brewer JP et al. (1998) Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest 101:1614-22 (Pubitemid 28198490)
33. Stolarski B, Kurowska-Stolarska M, Kewin P et al. (2010) IL-33 exacerbates eosinophil-mediated airway inflammation. J Immunol 185:3472-80
34. Townsend MJ, Fallon PG, Matthews DJ et al. (2000) T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J Exp Med 191:1069-76
35. Turnquist HR, Zhao Z, Rosborough BR et al. (2011) IL-33 expands suppressive CD11b\+ Gr-1int and regulatory t cells, including ST2L\+ Foxp3\+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol 187:4598-610
36. Xu D, Chan WL, Leung BP et al. (1998) Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med 187:787-94 (Pubitemid 28115194)
37. Yang Q, Li G, Zhu Y et al. (2011) IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8(\+) T cells. Eur J Immunol 41:3351-60