Neuroendocrine tumors of the gynecologic tract: Select topics

Seminars in Diagnostic Pathology

Volumn 30, Issue 3, 2013, Pages 224-233

  Rouzbahman, Marjan ^a,b   Clarke, Blaise ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Gynecologic tract; Neuroendocrine tumors

Indexed keywords

CHROMOGRANIN A; CYTOKERATIN; CYTOKERATIN CAM5.2; EPITHELIAL MEMBRANE ANTIGEN; NEURON SPECIFIC ENOLASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; VIMENTIN;

ARTICLE; CANCER PROGNOSIS; CARCINOID; DIFFERENTIAL DIAGNOSIS; ENDOMETRIUM TUMOR; FEMALE GENITAL TRACT TUMOR; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INSULAR CARCINOID; LARGE CELL NEUROENDOCRINE CARCINOMA; MERKEL CELL TUMOR; MITOSIS RATE; MUCINOUS CARCINOID; NEUROENDOCRINE TUMOR; OVARIAN SMALL CELL CARCINOMA OF HYPERCALCEMIC TYPE; OVARIAN SMALL CELL CARCINOMA PULMONARY TYPE; OVARY CARCINOMA; OVARY TERATOMA; PRIMARY TUMOR; PRIORITY JOURNAL; SMALL CELL CARCINOMA; STRUMAL CARCINOID; TRABECULAR CARCINOID; UTERINE CERVIX ATYPICAL CARCINOID TUMOR; UTERINE CERVIX TUMOR; UTERINE CERVIX TYPICAL CARCINOID TUMOR; UTERUS TUMOR; VAGINA TUMOR; VULVA TUMOR;

GYNECOLOGIC TRACT; NEUROENDOCRINE TUMORS;

FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; NEUROENDOCRINE TUMORS;

EID: 84885938243     PISSN: 07402570     EISSN: 19301111     Source Type: Journal    
DOI: 10.1053/j.semdp.2013.06.007     Document Type: Article

References (92)

1. Bottles K., Lacey C.G., Goldberg J., et al. Merkel cell carcinoma of the vulva. Obstet Gynecol 1984, 63(suppl 3):61S-65S.
2. Copeland L.J., Cleary K., Sneige N., Edwards C.L. Neuroendocrine (Merkel cell) carcinoma of the vulva: a case report and review of the literature. Gynecol Oncol 1985, 22(3):367-378.
3. Nicolaidou E, Mikrova A, Antoniou C, Katsambas A.D. Advances in Merkel Cell carcinoma pathogenesis and management: a recently discovered virus, a new international consensus staging system and new diagnostic codes. Br J Dermatol. 2012;166(1):16-21.
4. Sheikh ZA, Nair I, Vijaykumar DK, et al. Neuroendocrine tumor of vulva: a case report and review of literature. J Cancer Res Ther. 2010;6(3):365-366.
5. Loret d.e., Mola J.R., Hudock P.A., Steinetz C., et al. Merkel cell carcinoma of the vulva. Gynecol Oncol 1993, 51(2):272-276.
6. Buck C.B., Lowy D.R. Getting stronger: the relationship between a newly identified virus and Merkel cell carcinoma. J Invest Dermatol 2009, 129(1):9-11.
7. Feng H., Shuda M., Chang Y., Moore P.S. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008, 319(5866):1096-1100.
8. Colleran K.M., Burge M.R., Crooks L.A., Dorin R.I. Small cell carcinoma of the vagina causing Cushing's syndrome by ectopic production and secretion of ACTH: a case report. Gynecol Oncol 1997, 65(3):526-529.
9. Albores-Saavedra J., Larraza O., Poucell S., Rodriguez Martinez H.A. Carcinoid of the uterine cervix: additional observations on a new tumor entity. Cancer 1976, 38(6):2328-2342.
10. Louka M.H., Danoff B., Brodovsky H.S., Jahshan A.E. Carcinoid tumors of the uterine cervix: response to combination chemotherapy and radiotherapy. Am J Clin Oncol 1982, 5(5):487-493.
11. Miles P.A., Herrera G.A., Greenberg H., Rawding-Patterson G. Primary carcinoid tumor of the uterine cervix presenting as an adenosquamous carcinoma. The importance of electron microscopy and immunohistochemistry in evaluating poorly differentiated cervical neoplasms. Diagn Gynecol Obstet 1982, 4(4):327-337.
12. Albores-Saavedra J., Rodriguez-Martinez H.A., Larraza-Hernandez O. Carcinoid tumors of the cervix. Pathol Annu 1979, 14(Pt 1):273-291.
13. Hara H, Ishii E, Honda T, et al. Cytological features of atypical carcinoid combined with adenocarcinoma of the uterine cervix. Diagn Cytopathol.
14. Koch C.A., Azumi N., Furlong M.A., et al. Carcinoid syndrome caused by an atypical carcinoid of the uterine cervix. J Clin Endocrinol Metab 1999, 84(11):4209-4213.
15. Yoshida Y, Sato K, Katayama K, et al. Atypical metastatic carcinoid of the uterine cervix and review of the literature. J Obstet Gynaecol Res. 2011;37(6):636-640.
16. Sato Y., Shimamoto T., Amada S., et al. Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathological study of six cases. Int J Gynecol Pathol 2003, 22(3):226-230.
17. Gilks C.B., Young R.H., Gersell D.J., Clement P.B. Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am J Surg Pathol 1997, 21(8):905-914.
18. Ko M.L., Jeng C.J., Huang S.H., et al. Large cell neuroendocrine carcinoma of the uterine cervix associated with adenocarcinoma. Taiwan J Obstet Gynecol 2007, 46(1):68-70.
19. Cetiner H., Kir G., Akoz I., et al. Large-cell neuroendocrine carcinoma of the cervix associated with cervical-type invasive adenocarcinoma: a report of case and discussion of histogenesis. Int J Gynecol Cancer 2006, 16(1):438-442.
20. Embry JR, Kelly MG, Post MD, Spillman MA. Large cell neuroendocrine carcinoma of the cervix: prognostic factors and survival advantage with platinum chemotherapy. Gynecol Oncol. 2011;120(3):444-448.
21. Grayson W., Rhemtula H.A., Taylor L.F., et al. Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases. J Clin Pathol 2002, 55(2):108-114.
22. Tsunoda S., Jobo T., Arai M., et al. Small-cell carcinoma of the uterine cervix: a clinicopathologic study of 11 cases. Int J Gynecol Cancer 2005, 15(2):295-300.
23. Chen J., Macdonald O.K., Gaffney D.K. Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. Obstet Gynecol 2008, 111(6):1394-1402.
24. Conner M.G., Richter H., Moran C.A., et al. Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol 2002, 6(6):345-348.
25. Groben P., Reddick R., Askin F. The pathologic spectrum of small cell carcinoma of the cervix. Int J Gynecol Pathol 1985, 4(1):42-57.
26. Lee SW, Nam JH, Kim DY, et al. Unfavorable prognosis of small cell neuroendocrine carcinoma of the uterine cervix: a retrospective matched case-control study. Int J Gynecol Cancer. 2010;20(3):411-416.
27. Huang C.Y., Chen Y.L., Chu T.C., et al. Prognostic factors in women with early stage small cell carcinoma of the uterine cervix. Oncol Res 2009, 18(5-6):279-286.
28. Kim Y.M., Jung M.H., Kim D.Y., et al. Small cell carcinoma of the uterine cervix: clinicopathologic study of 20 cases in a single center. Eur J Gynaecol Oncol 2009, 30(5):539-542.
29. Abeler V.M., Holm R., Nesland J.M., Kjorstad K.E. Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients. Cancer 1994, 73(3):672-677.
30. Stoler M.H., Mills S.E., Gersell D.J., Walker A.N. Small-cell neuroendocrine carcinoma of the cervix. A human papillomavirus type 18-associated cancer. Am J Surg Pathol 1991, 15(1):28-32.
31. Iemura K., Sonoda T., Hayakawa A., et al. Small cell carcinoma of the uterine cervix showing Cushing's syndrome caused by ectopic adrenocorticotropin hormone production. Jpn J Clin Oncol 1991, 21(4):293-298.
32. Ishibashi-Ueda H., Imakita M., Yutani C., et al. Small cell carcinoma of the uterine cervix with syndrome of inappropriate antidiuretic hormone secretion. Mod Pathol 1996, 9(4):397-400.
33. van Nagell J.R., Powell D.E., Gallion H.H., et al. Small cell carcinoma of the uterine cervix. Cancer 1988, 62(8):1586-1593.
34. Alphandery C., Dagrada G., Frattini M., et al. Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. Acta Cytol 2007, 51(4):589-593.
35. Tsou M.H., Tan T.D., Cheng S.H., Chiou Y.K. Small cell carcinoma of the uterine cervix with large cell neuroendocrine carcinoma component. Gynecol Oncol 1998, 68(1):69-72.
36. Albores-Saavedra J., Latif S., Carrick K.S., et al. CD56 reactivity in small cell carcinoma of the uterine cervix. Int J Gynecol Pathol 2005, 24(2):113-117.
37. Gersell D.J., Mazoujian G., Mutch D.G., Rudloff M.A. Small-cell undifferentiated carcinoma of the cervix. A clinicopathologic, ultrastructural, and immunocytochemical study of 15 cases. Am J Surg Pathol 1988, 12(9):684-698.
38. Li JD, Zhuang Y, Li YF, et al. A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases. J Clin Pathol.
39. Chetty R., Clark S.P., Bhathal P.S. Carcinoid tumour of the uterine corpus. Virchows Arch A Pathol Anat Histopathol 1993, 422(1):93-95.
40. Gonzalez-Bosquet E., Gonzalez-Bosquet J., Garcia Jimenez A., et al. Carcinoid tumor of the uterine corpus. A case report. J Reprod Med 1998, 43(9):844-846.
41. Ju W., Park I.A., Kim S.H., et al. Small cell carcinoma of the uterine corpus manifesting with visual dysfunction. Gynecol Oncol 2005, 99(2):504-506.
42. Albores-Saavedra J., Martinez-Benitez B., Luevano E. Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. Int J Gynecol Pathol 2008, 27(3):333-339.
43. Bahig H., Portelance L., Legler C., et al. Small cell carcinoma of the endometrium: report of a case and review of the literature. Minerva Ginecol 2009, 61(4):365-369.
44. Bige O., Saatli B., Secil M., et al. Small cell neuroendocrine carcinoma of the endometrium and laparoscopic staging: a clinicopathologic study of a case and a brief review of the literature. Int J Gynecol Cancer 2008, 18(4):838-843.
45. Crowder S., Tuller E. Small cell carcinoma of the female genital tract. Semin Oncol 2007, 34(1):57-63.
46. Huntsman D.G., Clement P.B., Gilks C.B., Scully R.E. Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases. Am J Surg Pathol 1994, 18(4):364-375.
47. Hwang JH, Lee JK, Lee NW, Lee KW Primary small cell carcinoma of the endometrium: report of a case with immunochemical studies. J Reprod Med. 2010;55(1-2):81-86.
48. Matsumoto H, Takai N, Nasu K, Narahara H Small cell carcinoma of the endometrium: a report of two cases. J Obstet Gynaecol Res. 2011;37(11):1739-1743.
49. Terada T. KIT-positive primary small cell carcinoma of the endometrium: a case report with immunohistochemical and molecular genetic analysis of KIT and PDGFRA genes. Arch Gynecol Obstet. 2010;282(4):413-416.
50. Tiseo M, Bersanelli M, Corradi D, et al. Endometrial metastasis of lung adenocarcinoma: a case report. Tumori. 2011;97(3):411-414.
51. Deodhar KK, Kerkar RA, Suryawanshi P et al. Large cell neuroendocrine carcinoma of the endometrium: an extremely uncommon diagnosis, but worth the efforts. J Cancer Res Ther. 2011;7(2):211-213.
52. Mulvany N.J., Allen D.G. Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium. Int J Gynecol Pathol 2008, 27(1):49-57.
53. Posligua L., Malpica A., Liu J., et al. Combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium with pagetoid spread. Arch Pathol Lab Med 2008, 132(11):1821-1824.
54. Terada T. Large cell neuroendocrine carcinoma with sarcomatous changes of the endometrium: a case report with immunohistochemical studies and molecular genetic study of KIT and PDGFRA. Pathol Res Pract. 2010;206(6):420-425.
55. Young R.H., Oliva E., Scully R.E. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol 1994, 18(11):1102-1116.
56. Young R.H., Oliva E., Scully R.E. Small cell carcinoma of the hypercalcemic type in the ovary. Gynecol Oncol 1995, 57(1):7-8.
57. McCluggage W.G. Ovarian neoplasms composed of small round cells: a review. Adv Anat Pathol 2004, 11(6):288-296.
58. Chen F., Koenig C., Heller D.S.A. 26-year-old woman with right ovarian mass. Small cell carcinoma of ovary, hypercalcemic type. Arch Pathol Lab Med 2006, 130(4):e56-e58.
59. Forster C., Ostertag H., Schmitt J., Roessner A. Small cell carcinoma of the ovary, hypercalcemic type. A case report with immunohistochemical, ultrastructural and cytophotometric analysis and review of the literature. Gen Diagn Pathol 1997, 142(5-6):365-370.
60. McCluggage W.G., Oliva E., Connolly L.E., et al. An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. Int J Gynecol Pathol 2004, 23(4):330-336.
61. Carlson J.W., Nucci M.R., Brodsky J., et al. Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. Histopathology 2007, 51(3):305-312.
62. Eichhorn J.H., Young R.H., Scully R.E. Primary ovarian small cell carcinoma of pulmonary type. A clinicopathologic, immunohistologic, and flow cytometric analysis of 11 cases. Am J Surg Pathol 1992, 16(10):926-938.
63. Fukunaga M., Endo Y., Miyazawa Y., Ushigome S. Small cell neuroendocrine carcinoma of the ovary. Virchows Arch 1997, 430(4):343-348.
64. Grandjean M., Legrand L., Waterkeyn M., et al. Small cell carcinoma of pulmonary type inside a microinvasive mucinous cystadenocarcinoma of the ovary: a case report. Int J Gynecol Pathol 2007, 26(4):426-431.
65. Mebis J., De Raeve H., Baekelandt M., et al. Primary ovarian small cell carcinoma of the pulmonary type: a case report and review of the literature. Eur J Gynaecol Oncol 2004, 25(2):239-241.
66. Reckova M, Mego M, Rejlekova K, et al. Small-cell carcinoma of the ovary with breast metastases: a case report. Klin Onkol. 2010;23(1):43-45.
67. Rund C.R., Fischer E.G. Perinuclear dot-like cytokeratin 20 staining in small cell neuroendocrine carcinoma of the ovary (pulmonary-type). Appl Immunohistochem Mol Morphol 2006, 14(2):244-248.
68. Chang D.H., Hsueh S., Soong Y.K. Small cell carcinoma with neurosecretory granules arising in an ovarian dermoid cyst. Gynecol Oncol 1992, 46(2):246-250.
69. Lim S.C., Choi S.J., Suh C.H. A case of small cell carcinoma arising in a mature cystic teratoma of the ovary. Pathol Int 1998, 48(10):834-839.
70. Chatzipantelis P., Mavrogiorgis A., Kairi-Vassilatou E., Pafiti A. Ovarian neoplasm composed of an insular carcinoid tumor and a borderline mucinous cystadenoma arising in a mature cystic teratoma: a case report. Eur J Gynaecol Oncol 2006, 27(6):636-637.
71. Diaz-Montes T.P., Rosenthal L.E., Bristow R.E., Grumbine F.C. Primary insular carcinoid of the ovary. Gynecol Oncol 2006, 101(1):175-178.
72. Lagoudianakis E.E., Markogiannakis H., Karantzikos G., et al. Primary insular carcinoid of the ovary. Eur J Gynaecol Oncol 2008, 29(5):554-555.
73. Robboy S.J. Insular carcinoid of ovary associated with malignant mucinous tumors. Cancer 1984, 54(10):2273-2276.
74. Robboy S.J., Norris H.J., Scully R.E. Insular carcinoid primary in the ovary. A clinicopathologic analysis of 48 cases. Cancer 1975, 36(2):404-418.
75. Rabban J.T., Lerwill M.F., McCluggage W.G., et al. Primary ovarian carcinoid tumors may express CDX-2: a potential pitfall in distinction from metastatic intestinal carcinoid tumors involving the ovary. Int J Gynecol Pathol 2009, 28(1):41-48.
76. Ashton M.A. Strumal carcinoid of the ovary associated with hyperinsulinaemic hypoglycaemia and cutaneous melanosis. Histopathology 1995, 27(5):463-467.
77. Brunaud L., Antunes L., Sebbag H., et al. Ovarian strumal carcinoid tumor responsible for carcinoid heart disease. Eur J Obstet Gynecol Reprod Biol 2001, 98(1):124-126.
78. Kurabayashi T, Minamikawa T, Nishijima S, et al. Primary strumal carcinoid tumor of the ovary with multiple bone and breast metastases. J Obstet Gynaecol Res. 2010;36(3):567-571.
79. Robboy S.J., Scully R.E. Strumal carcinoid of the ovary: an analysis of 50 cases of a distinctive tumor composed of thyroid tissue and carcinoid. Cancer 1980, 46(9):2019-2034.
80. Alenghat E., Okagaki T., Talerman A. Primary mucinous carcinoid tumor of the ovary. Cancer 1986, 58(3):777-783.
81. Baker P.M., Oliva E., Young R.H., et al. Ovarian mucinous carcinoids including some with a carcinomatous component: a report of 17 cases. Am J Surg Pathol 2001, 25(5):557-568.
82. Buis CC, van Doorn HC, Dinjens WN, Ewing PC Mucinous carcinoid of the ovary: report of a case with metastasis in the contralateral ovary after ten years. Rare Tumors. 2010;2(3):e39.
83. Wolpert H.R., Fuller A.F., Bell D.A. Primary mucinous carcinoid tumor of the ovary. A case report. Int J Gynecol Pathol 1989, 8(2):156-162.
84. Ahmed Z., Aftab K., Kayani N. Ovarian primary neuroendocrine carcinoma of non-small cell type: report of an extremely rare neoplasm. J Pak Med Assoc 2005, 55(2):82-84.
85. Chen K.T. Composite large-cell neuroendocrine carcinoma and surface epithelial-stromal neoplasm of the ovary. Int J Surg Pathol 2000, 8(2):169-174.
86. Collins R.J., Cheung A., Ngan H.Y., et al. Primary mixed neuroendocrine and mucinous carcinoma of the ovary. Arch Gynecol Obstet 1991, 248(3):139-143.
87. Eichhorn J.H., Lawrence W.D., Young R.H., Scully R.E. Ovarian neuroendocrine carcinomas of non-small-cell type associated with surface epithelial adenocarcinomas. A study of five cases and review of the literature. Int J Gynecol Pathol 1996, 15(4):303-314.
88. Hirasawa T. Ovarian neuroendocrine carcinoma associated with mucinous carcinoma and teratoma. Nihon Rinsho 2004, 62(5):973-978.
89. Jones K., Diaz J.A., Donner L.R. Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma. Int J Gynecol Pathol 1996, 15(2):167-170.
90. Khurana K.K., Tornos C., Silva E.G. Ovarian neuroendocrine carcinoma associated with a mucinous neoplasm. Arch Pathol Lab Med 1994, 118(10):1032-1034.
91. Ohira S., Itoh K., Shiozawa T., et al. Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia. Int J Gynecol Pathol 2004, 23(4):393-397.
92. Veras E., Deavers M.T., Silva E.G., Malpica A. Ovarian nonsmall cell neuroendocrine carcinoma: a clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol 2007, 31(5):774-782.