Ovarian nonsmall cell neuroendocrine carcinoma: A clinicopathologic and immunohistochemical study of 11 cases

American Journal of Surgical Pathology

Volumn 31, Issue 5, 2007, Pages 774-782

  Veras, Emanuela ^a   Deavers, Michael T ^b   Silva, Elvio G ^b   Malpica, Anais ^b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

C kit; Immunohistochemistry; Neuroendocrine carcinoma; Nonsmall cell neuroendocrine carcinoma; Ovary; Synaptophysin; Tumor

Indexed keywords

CD56 ANTIGEN; CHROMOGRANIN A; CISPLATIN; CYTOKERATIN 20; CYTOKERATIN 7; KERATIN; PEROXIDASE; STEM CELL FACTOR; SYNAPTOPHYSIN;

ABDOMINAL HYSTERECTOMY; ABDOMINAL PAIN; ADULT; APPENDECTOMY; ARTICLE; ASCITES; BLOATING; CANCER CHEMOTHERAPY; CANCER STAGING; CLINICAL FEATURE; CONTROLLED STUDY; ENDOMETRIOID CARCINOMA; EPITHELIUM TUMOR; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOSIS RATE; MUCINOUS CARCINOMA; MULTIPLE CYCLE TREATMENT; NEUROSECRETORY CELL; OVARIAN NONSMALL CELL NEUROENDOCRINE CARCINOMA; OVARY CARCINOMA; OVARY CYST; PELVIS PAIN SYNDROME; PROGNOSIS; SALPINGOOOPHORECTOMY; TERATOMA; VAGINA BLEEDING;

ADULT; CARCINOMA, NEUROENDOCRINE; COMBINED MODALITY THERAPY; FATAL OUTCOME; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; NEOPLASMS, MULTIPLE PRIMARY; OVARIAN NEOPLASMS; REMISSION INDUCTION; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 34247606445     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000213422.53750.d1     Document Type: Article

References (32)

1. Ahmed Z, Aftab K, Kayani N. Ovarian primary neuroendocrine carcinoma of non-small cell type: report of an extremely rare neoplasm. J Pak Med Assoc. 2005;55:82-84.
2. Akintola-Ogunremi O, Pfeifer JD, Tan BR, et al. Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomas. Am J Surg Pathol. 2003;27:1551-1558.
3. Albores-Saavedra J, Latif S, Carrick KS, et al. CD56 reactivity in small cell carcinoma of the uterine cervix. Int J Gynecol Pathol. 2005;24:113-117.
4. Behnam K, Kabus D, Behnam M. Primary ovarian undifferentiated non-small cell carcinoma, neuroendocrine type. Gynecol Oncol. 2004;92:372-375.
5. Chen KT. Composite large-cell neuroendocrine carcinoma and surface epithelial-stromal neoplasm of the ovary. Int J Surg Pathol. 2000;8:169-174.
6. Collins R, Cheung A, Ngan H, et al. Primary mixed neuroendocrine and mucinous carcinoma of the ovary. Arch Gynecol Obstet. 1991;248:139-143.
7. Eichhorn J, Lawrence W, Young R, et al. Ovarian neuroendocrine carcinomas of non-small-cell type associated with surface epithelial adenocarcinomas - A study of five cases and review of the literature. Int J Gynecol Pathol. 1996;15:303-314.
8. Evans AJ, Humphrey PA, Belani J, et al. Large cell neuroendocrine carcinoma of the prostate. A clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancer. Am J Surg Pathol. 2006;30:684-693.
9. Feinmesser M, Halpern M, Kaganovsky E, et al. C-kit expression in primary and metastatic merkel cell carcinoma. Am J Dermatopathol. 2004;26:458-462.
10. Hirasawa T. Ovarian neuroendocrine carcinoma associated with mucinous carcinoma and teratoma. Nippon Rinsho. 2004;62:973-978.
11. Hiroshima K, Iyoda A, Shida T, et al. Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. Mod Pathol. 2006;19:1358-1368.
12. Hsu S, Raine L, Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol. 1981;75:816-821.
13. Jones K, Diaz J, Donner L. Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma. Int J Gynecol Pathol. 1996;15:167-170.
14. Khurana K, Tornos C, Silva E. Ovarian neuroendocrine carcinoma associated with a mucinous neoplasm. Arch Pathol Lab Med. 1994;118:1032-1034.
15. Kontogianni K, Nicholson AG, Butcher D, et al. CD56: a useful tool for the diagnosis of small cell lung carcinomas on biopsies with extensive crush artefact. J Clin Pathol. 2005;58:978-980.
16. Kurokawa M, Nabeshima K, Akiyama Y, et al. CD56: a useful marker for diagnosing Merkel cell carcinoma. J Dermatol Sci. 2003;31:219-224.
17. McNiff JM, Cowper SE, Lazova R, et al. CD56 staining in Merkel cell carcinoma and natural killer-cell lymphoma: magic bullet, diagnostic pitfall, or both? J Cutan Pathol. 2005;32: 541-545.
18. Micke P, Basrai M, Faldum A, et al. Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. Clin Cancer Res. 2003;9188-9194.
19. Ngan HTS, Collins RJ, Wong LC, et al. The value of tumor markers in a mixed tumor, mucinous and neuroendocrine carcinoma of the ovary. Gynecol Oncol 1989;35:272-274.
20. Ohira S, Itoh K, Shiozawa T, et al. Ovarian NSCNEC with paraneoplastic parathyroid hormone-related hypercalcemia. Int J Gynecol Pathol. 2004;23:393-397.
21. Pan CX, Yang XJ, Lopez-Beltran A, et al. C-kit expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications. Mod Pathol. 2005;18:320-323.
22. Pelosi G, Masullo M, Leon ME, et al. CD117 immunoreactivity in high-grade neuroendocrine tumors of the lung: a comparative study of 39 large-cell neuroendocrine carcinomas and 27 surgically resected small-cell carcinomas. Virchows Arch. 2004;445:449-455. Epub 2004 September 16.
23. Rayhan N, Sano T, Qian ZR, et al. Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach. J Med Invest. 2005;52:191-202.
24. Reyes A, Moran CA, Suster S, et al. Neuroendocrine carcinomas (carcinoid tumor) of the testis. A clinicopathologic and immunohistochemical study of ten cases. Am J Clin Pathol. 2003;120:182-187.
25. Sasaki E, Sasano N, Kimura N, et al. Demonstration of neuroendocrine cells in ovarian mucinous tumors. Int J Gynecol Pathol 1989;8:189-200.
26. Su LD, Fullen DR, Lowe L, et al. CD117 (KIT receptor) expression in Merkel cell carcinoma. Am J Dermatopathol. 2002;24:289-293.
27. Tiffett O, Nicholson AG, Ladas G, et al. A clinicopathologic study of 12 neuroendocrine tumors arising in the thymus. Chest. 2004;125:2368-2369.
28. Wang HL, Lu DW. Overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervix. Mod Pathol. 2004;17:732-738.
29. Yamasaki T, Shimazaki H, Aida S, et al. Primary small cell (oat cell) carcinoma of the breast: report of a case and review of the literature. Pathol Int. 2000;50:914-918.
30. Yang DT, Holden JA, Florell SR. CD117, CK20, TTF-1, and DNA topoisomerase II-alpha antigen expression in small cell tumors. J Cutan Pathol. 2004;31:254-261.
31. Yao JL, Madeb R, Bourne P, et al. Small cell carcinoma of the prostate: an immunohistochemical study. Am J Surg Pathol. 2006; 30:705-712.
32. Zhao P, Hou N, Shao Y, et al. Clinicopathological significance of expression of c-kit protein in neuroendocrine lung carcinoma. Zhonghua Yi Xue Za Zhi. 2005;85:1526-1529.