BCL2A1 is a potential biomarker for postoperative seizure control in patients with low-grade gliomas

CNS Neuroscience and Therapeutics

Volumn 19, Issue 11, 2013, Pages 882-888

  You, Gan ^a   Feng, Lin ^b   Yan, Wei ^a   Zhang, Wei ^a   Wang, Yong Zhi ^a   Li, Shao Wu ^a   Li, Shou Wei ^c   Li, Gui Lin ^d   Song, Yi Jun ^e   Kang, Chun Sheng ^e   You, Yong Ping ^f   Jiang, Tao ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CANCER HOSPITAL   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e TIANJIN MEDICAL UNIVERSITY   (China)

^f THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

BCL2A1; Epilepsy; Glioma; Prognosis; Seizure

Indexed keywords

BCL2 RELATED PROTEIN A1; GLUTATHIONE PEROXIDASE 3; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 2; TRANSCRIPTION FACTOR HES 5; VALPROIC ACID;

ADULT; ANGPT2 GENE; ARTICLE; ASTROCYTOMA; BCL2A1 GENE; CCL8 GENE; CELLS; CH25H GENE; CUZD1 GENE; DISEASE CONTROL; FEMALE; GBP2 GENE; GEM GENE; GENE; GENE EXPRESSION PROFILING; GPX3 GENE; HEREDITY; HES5 GENE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIOMA; POSTOPERATIVE PERIOD; PROGNOSIS; QUANTITATIVE ANALYSIS; RECURRENT DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEIZURE; SURVIVAL; TUMOR LOCALIZATION; ZNF880 GENE;

BCL2A1; EPILEPSY; GLIOMA; PROGNOSIS; SEIZURE;

ADOLESCENT; ADULT; BRAIN NEOPLASMS; FEMALE; GLIOMA; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECURRENCE; SEIZURES; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84885929853     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12148     Document Type: Article

References (28)

1. Jackson JH. Localized convulsions from tumor of the brain. Brain 1882;5:364-374.
2. van Breemen MS, Wilms EB, Vecht CJ. Epilepsy in patients with brain tumours: Epidemiology, mechanisms, and management. Lancet Neurol 2007;6:421-430.
3. Lynam LM, Lyons MK, Drazkowski JF, et al. Frequency of seizures in patients with newly diagnosed brain tumors: A retrospective review. Clin Neurol Neurosurg 2007;109:634-638.
4. Taphoorn MJ, Klein M. Cognitive deficits in adult patients with brain tumours. Lancet Neurol 2004;3:159-168.
5. Klein M, Engelberts NH, van der Ploeg HM, et al. Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life. Ann Neurol 2003;54:514-520.
6. Chang EF, Potts MB, Keles GE, et al. Seizure characteristics and control following resection in 332 patients with low-grade gliomas. J Neurosurg 2008;108:227-235.
7. Chaichana KL, Parker SL, Olivi A, Quinones-Hinojosa A. Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. J Neurosurg 2009;111:282-292.
8. Luyken C, Blumcke I, Fimmers R, et al. The spectrum of long-term epilepsy-associated tumors: Long-term seizure and tumor outcome and neurosurgical aspects. Epilepsia 2003;44:822-830.
9. Engel J Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001;42:796-803.
10. Brell M, Tortosa A, Verger E, et al. Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. Clin Cancer Res 2005;11:5167-5174.
11. Kujas M, Lejeune J, Benouaich-Amiel A, et al. Chromosome 1p loss: A favorable prognostic factor in low-grade gliomas. Ann Neurol 2005;58:322-326.
12. You G, Sha ZY, Jiang T. The pathogenesis of tumor-related epilepsy and its implications for clinical treatment. Seizure 2012;21:153-159.
13. Beaumont A, Whittle IR. The pathogenesis of tumour associated epilepsy. Acta Neurochir (Wien) 2000;142:1-15.
14. Buckingham SC, Campbell SL, Haas BR, et al. Glutamate release by primary brain tumors induces epileptic activity. Nat Med 2011;17:1269-1274.
15. Fassunke J, Majores M, Tresch A, et al. Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. Brain 2008;131:3034-3050.
16. Aronica E, Boer K, Becker A, et al. Gene expression profile analysis of epilepsy-associated gangliogliomas. Neuroscience 2008;151:272-292.
17. You G, Sha ZY, Yan W, et al. Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of low-grade gliomas: A clinicopathological study. Neuro Oncol 2012;14:230-241.
18. de Groot M, Aronica E, Heimans JJ, Reijneved JC. Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. Neurology 2011;77:532-539.
19. Choi SS, Park SH, Kim UJ, Shin HS. Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3. Mamm Genome 1997;8:781-782.
20. Nagy B, Lundan T, Larramendy ML, et al. Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma. Br J Haematol 2003;120:434-441.
21. Monti S, Savage KJ, Kutok JL, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005;105:1851-1861.
22. Choi SS, Park IC, Yun JW, Sung YC, Hong SI, Shin HS. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene 1995;11:1693-1698.
23. Beverly LJ, Varmus HE. MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene 2009;28:1274-1279.
24. Karsan A, Yee E, Kaushansky K, Harlan JM. Cloning of human Bcl-2 homologue: Inflammatory cytokines induce human A1 in cultured endothelial cells. Blood 1996;87:3089-3096.
25. Martinon F, Burns K, Tschopp J. The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417-426.
26. Schroder K, Tschopp J. The inflammasomes. Cell 2010;140:821-832.
27. Noble KE, Wickremasinghe RG, DeCornet C, Panayiotidis P, Yong KL. Monocytes stimulate expression of the Bcl-2 family member, A1, in endothelial cells and confer protection against apoptosis. J Immunol 1999;162:1376-1383.
28. Samadani U, Judkins AR, Akpalu A, Aronica E, Crino PB. Differential cellular gene expression in ganglioglioma. Epilepsia 2007;48:646-653.