Fine tuning and measurement of mechanical properties of crosslinked hyaluronic acid hydrogels as biomimetic scaffold coating in regenerative medicine

Journal of the Mechanical Behavior of Biomedical Materials

Volumn 29, Issue , 2014, Pages 309-316

  Credi, Caterina ^a   Biella, Serena ^a   De Marco, Carmela ^a   Levi, Marinella ^a   Suriano, Raffaella ^a   Turri, Stefano ^a  

^a POLITECNICO DI MILANO   (Italy)

Author keywords

Biopolymers; Crosslinking; Hydrogels; Mechanical properties; Rheology

Indexed keywords

BIOMIMETIC SCAFFOLDS; CROSS LINKING AGENTS; CROSS-LINKING PROCESS; EXTRACELLULAR MATRICES; HYALURONIC ACID HYDROGELS; NANOINDENTATION EXPERIMENTS; REGENERATIVE MEDICINE; RHEOLOGICAL ANALYSIS;

ATOMIC FORCE MICROSCOPY; BIOCOMPATIBILITY; BIOMIMETICS; BIOPOLYMERS; COATINGS; CROSSLINKING; EXPERIMENTS; HYALURONIC ACID; MECHANICAL PROPERTIES; ORGANIC ACIDS; PROCESS CONTROL; RHEOLOGY; STEM CELLS; TISSUE;

HYDROGELS;

HYALURONIC ACID; SULFONE DERIVATIVE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BIOCOMPATIBILITY; CROSS LINKING; DENSITY; EVAPORATION; EXTRACELLULAR MATRIX; FLOW KINETICS; HYDROGEL; MATERIAL COATING; MECHANICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; REACTION TIME; REGENERATIVE MEDICINE; RIGIDITY; STEM CELL NICHE; STOICHIOMETRY; SYNTHESIS; THERMOGRAVIMETRY; WATER CONTENT; YOUNG MODULUS;

BIOPOLYMERS; CROSSLINKING; HYDROGELS; MECHANICAL PROPERTIES; RHEOLOGY;

BIOMIMETIC MATERIALS; HYALURONIC ACID; HYDROGELS; MATERIALS TESTING; MECHANICAL PROCESSES; MICROSCOPY, ATOMIC FORCE; REGENERATIVE MEDICINE; RHEOLOGY; SULFONES;

EID: 84885922539     PISSN: 17516161     EISSN: 18780180     Source Type: Journal    
DOI: 10.1016/j.jmbbm.2013.09.025     Document Type: Article

References (35)

1. Anseth K.S., Bowman C.N., Brannon-Peppas L. Mechanical properties of hydrogels and their experimental determination. Biomaterials 1996, 17(17):1647-1657.
2. Baier Leach J., et al. Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. Biotechnol. Bioeng. 2003, 82(5):578-589.
3. Bencherif S.A., et al. Influence of the degree of methacrylation on hyaluronic acid hydrogels properties. Biomaterials 2008, 29(12):1739-1749.
4. Burdick J.A., Prestwich G.D. Hyaluronic acid hydrogels for biomedical applications. Adv. Mater. 2011, 23(12):H41-H56.
5. Butt H.-J., Cappella B., Kappl M. Force measurements with the atomic force microscope: technique, interpretation and applications. Surf. Sci. Rep. 2005, 59(1-6):1-152.
6. Camci-Unal G., et al. Synthesis and characterization of hybrid hyaluronic acid-gelatin hydrogels. Biomacromolecules 2013, 14(4):1085-1092.
7. Clifford C.A., Seah M.P. Quantification issues in the identification of nanoscale regions of homopolymers using modulus measurement via AFM nanoindentation. Appl. Surf. Sci. 2005, 252(5):1915-1933.
8. Collins M.N., Birkinshaw C. Comparison of the effectiveness of four different crosslinking agents with hyaluronic acid hydrogel films for tissue-culture applications. J. Appl. Polym. Sci. 2007, 104(5):3183-3191.
9. Collins M.N., Birkinshaw C. Morphology of crosslinked hyaluronic acid porous hydrogels. J. Appl. Polym. Sci. 2011, 120(2):1040-1049.
10. Discher D.E., Janmey P., Wang Y.-l. Tissue cells feel and respond to the stiffness of their substrate. Science 2005, 310(5751):1139-1143.
11. Engler A.J., et al. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126(4):677-689.
12. Evans N.D., et al. Substrate stiffnessaffects early differentiation events in embryonic stem cells. Eur. Cells Mater. 18 2009, 1-14.
13. Flores-Merino M.V., et al. Nanoscopic mechanical anisotropy in hydrogel surfaces. Soft Matter 2010, 6(18):4466-4470.
14. Flory P.J. Principles of Polymer Chemistry 1953, xvi:672. Cornell University Press, Ithaca; London.
15. Gaffney J., et al. Therapeutic applications of hyaluronan. Molecular Biosystems 2010, 6(3):437-443.
16. Hachet E., et al. Design of biomimetic cell-interactive substrates using hyaluronic acid hydrogels with tunable mechanical properties. Biomacromolecules 2012, 13(6):1818-1827.
17. Ibrahim S., Kang Q.K., Ramamurthi A. The impact of hyaluronic acid oligomer content on physical, mechanical, and biologic properties of divinyl sulfone-crosslinked hyaluronic acid hydrogels. J. Biomed. Mater. Res. Part A 2010, 94A(2):355-370.
18. Ibrahim S., et al. A surface-tethered model to assess size-specific effects of hyaluronan (HA) on endothelial cells. Biomaterials 2007, 28(5):825-835.
19. Ji Y., et al. Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials 2006, 27(20):3782-3792.
20. Johnson K.L., Kendall K., Roberts A.D. Surface energy and the contact of elastic solids. Proc. R. Soc. London Ser. A. Math. Phys. Sci. 1971, 324(1558):301-313.
21. Kenne L., et al. Modification and cross-linking parameters in hyaluronic acid hydrogels-definitions and analytical methods. Carbohyd. Polym. 2013, 91(1):410-418.
22. Kim I.L., Mauck R.L., Burdick J.A. Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid. Biomaterials 2011, 32(34):8771-8782.
23. Lin D.C., Dimitriadis E.K., Horkay F. Robust strategies for automated AFM force curve analysis-II: Adhesion-influenced indentation of soft, elastic materials. J. Biomech. Eng. 2007, 129(6):904-912.
24. Lin D.C., Horkay F. Nanomechanics of polymer gels and biological tissues: a critical review of analytical approaches in the Hertzian regime and beyond. Soft Matter 2008, 4(4):669-682.
25. Markert, C.D., et al., Characterizing the micro-scale elastic modulus of hydrogels for use in regenerative medicine. Journal of the Mechanical Behavior of Biomedical Materials, (0).
26. Marsano E., et al. Behaviour of gels based on (hydroxypropyl) cellulose methacrylate. Polymer 2000, 41(21):7691-7698.
27. Ouasti S., et al. Network connectivity, mechanical properties and cell adhesion for hyaluronic acid/PEG hydrogels. Biomaterials 2011, 32(27):6456-6470.
28. Peppas N.A., et al. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv. Mater. 2006, 18(11):1345-1360.
29. Schante C.E., et al. Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications. Carbohyd. Polym. 2011, 85(3):469-489.
30. Sneddon I.N. The relation between load and penetration in the axisymmetric boussinesq problem for a punch of arbitrary profile. Int. J. Eng. Sci. 1965, 3(1):47-57.
31. Takagi A., et al. Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11). J. Controlled Release 2006, 115(2):134-139.
32. Treloar L.R.G. The Physics of Rubber Elasticity 2005, xii:310. Clarendon Press, Oxford. third ed.
33. Wagner R., et al. Uncertainty quantification in nanomechanical measurements using the atomic force microscope. Nanotechnology 2011, 22(45):455703.
34. Xu X., et al. Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks. Soft Matter 2012, 8(12):3280-3294.
35. Yeom J., et al. Effect of cross-linking reagents for hyaluronic acid hydrogel dermal fillers on tissue augmentation and regeneration. Bioconjugate Chem. 2010, 21(2):240-247.