Comparison of HSCORE assessment of endometrial β3 integrin subunit expression with digital HSCORE using computerized image analysis (ImageJ)

Analytical and Quantitative Cytology and Histology

Volumn 35, Issue 4, 2013, Pages 210-216

  Fuhrich, Daniele G ^a   Lessey, Bruce A ^a   Savaris, Ricardo F ^b  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Beta3 integrin; Endometrium; HSCORE; ImageJ; Infertility

Indexed keywords

BETA3 INTEGRIN; DIAMINOBENZIDINE;

ARTICLE; COMPUTER PROGRAM; ENDOMETRIUM BIOPSY; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMATIC REVIEW; COMPUTER ANALYSIS; DIGITAL HISTOLOGICAL SCORE; ENDOMETRIUM; FEMALE INFERTILITY; HISTOLOGICAL SCORE; IMAGING SOFTWARE; INTERMETHOD COMPARISON; MEDICAL EXPERT; MENSTRUAL CYCLE; PROTEIN SUBUNIT; SCIENTIST; SCORING SYSTEM;

ADULT; ENDOMETRIUM; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFERTILITY, FEMALE; INTEGRIN BETA3; OBSERVER VARIATION; PATHOLOGY, CLINICAL; REPRODUCIBILITY OF RESULTS;

EID: 84885905851     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Donaghay M, Lessey BA: Uterine receptivity: Alterations associated with benign gynecological disease. Semin Reprod Med 2007;25:461-475
2. Cakmak H, Taylor HS: Implantation failure: Molecular mechanisms and clinical treatment. Hum Reprod Update 2011;17:242-253
3. Revel A: Defective endometrial receptivity. Fertil Steril 2012; 97:1028-1032
4. Lessey BA, Damjanovich L, Coutifaris C, Castelbaum A, Albelda SM, Buck CA: Integrin adhesion molecules in the human endometrium: Correlation with the normal and abnormal menstrual cycle. J Clin Invest 1992;90:188-195
5. Lessey BA, Castelbaum AJ, Buck CA, Lei Y, Yowell CW, Sun J: Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril 1994;62: 497-506
6. Lessey BA, Castelbaum AJ, Sawin SW, Buck CA, Schinnar R, Bilker W, Strom BL: Aberrant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab 1994;79:643-649
7. Meyer WR, Castelbaum AJ, Somkuti S, Sagoskin AW, Doyle M, Harris JE, Lessey BA: Hydrosalpinges adversely affect markers of endometrial receptivity. Hum Reprod 1997;12: 1393-1398
8. Savaris RF, Pedrini JL, Flores R, Fabris G, Zettler CG: Expression of alpha 1 and beta 3 integrins subunits in the endometrium of patients with tubal phimosis or hydrosalpinx. Fertil Steril 2006;85:188-192
9. Apparao KB, Murray MJ, Fritz MA, Meyer WR, Chambers AF, Truong PR, Lessey BA: Osteopontin and its receptor alphavbeta(3) integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab 2001;86:4991-5000
10. Lessey BA, Castelbaum AJ, Sawin SW, Sun J: Integrins as markers of uterine receptivity in women with primary unexplained infertility. Fertil Steril 1995;63:535-542
11. Ceydeli N, Kaleli S, Calay Z, Erel CT, Akbas F, Ertungealp E: Difference in alpha(v)beta3 integrin expression in endometrial stromal cell in subgroups of women with unexplained infertility. Eur J Obstet Gynecol Reprod Biol 2006;126:206-211
12. Boroujerdnia MG, Nikbakht R: Beta3 integrin expression within uterine endometrium and its relationship with unexplained infertility. Pak J Biol Sci 2008;11:2495-2499
13. Creus M, Balasch J, Ordi J, Fábregues F, Casamitjana R, Quinto L, Coutifaris C, Vanrell JA: Integrin expression in normal and out-of-phase endometria. Hum Reprod 1998;13: 3460-3468
14. Casals G, Ordi J, Creus M, Fábregues F, Casamitjana R, Quinto L, Campo E, Balasch J: Osteopontin and alphavbeta3 integrin expression in the endometrium of infertile and fertile women. Reprod Biomed Online 2008;16:808-816
15. Casals G, Ordi J, Creus M, Fábregues F, Carmona F, Casamitjana R, Balasch J: Osteopontin and alphavbeta3 integrin as markers of endometrial receptivity: The effect of different hormone therapies. Reprod Biomed Online 2010;21:349-359
16. Casals G, Ordi J, Creus M, Fábregues F, Carmona F, Casamitjana R, Balasch J: Expression pattern of osteopontin and avβ3 integrin during the implantation window in infertile patients with early stages of endometriosis. Hum Reprod 2012; 27:805-813
17. Hii LL, Rogers PA: Endometrial vascular and glandular expression of integrin alpha(v)beta3 in women with and without endometriosis. Hum Reprod 1998;13:1030-1035
18. Meng CX, Marions L, Byström B, Gemzell-Danielsson K: Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity. Hum Reprod 2010;25:874-883
19. Gonzalez RR, Palomino A, Boric A, Vega M, Devoto L: A quantitative evaluation of alpha1, alpha4, alphaV and beta3 endometrial integrins of fertile and unexplained infertile women during the menstrual cycle: A flow cytometric appraisal. Hum Reprod 1999;14:2485-2492
20. Usadi RS, Groll JM, Lessey BA, Lininger RA, Zaino RJ, Fritz MA, Young SL: Endometrial development and function in experimentally induced luteal phase deficiency. J Clin Endocrinol Metab 2008;93:4058-4064
21. Quezada S, Avellaira C, Johnson MC, Gabler F, Fuentes A, Vega M: Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Fertil Steril 2006;85:1017-1026
22. Budwit-Novotny DA, McCarty KS, Cox EB, Soper JT, Mutch DG, Creasman WT, Flowers JL, McCarty KS Jr: Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody. Cancer Res 1986; 46:5419-5425
23. Ruifrok AC, Johnston DA: Quantification of histochemical staining by color deconvolution. Anal Quant Cytol Histol 2001;23:291-299
24. Vrekoussis T, Chaniotis V, Navrozoglou I, Dousias V, Pavlakis K, Stathopoulos EN, Zoras O: Image analysis of breast cancer immunohistochemistry-stained sections using ImageJ: An RGB-based model. Anticancer Res 2009;29:4995-4998
25. Drury JA, Nik H, van Oppenraaij RH, Tang AW, Turner MA, Quenby S: Endometrial cell counts in recurrent miscarriage: A comparison of counting methods. Histopathology 2011;59: 1156-1162
26. Helps SC, Thornton E, Kleinig TJ, Manavis J, Vink R: Automatic nonsubjective estimation of antigen content visualized by immunohistochemistry using color deconvolution. Appl Immunohistochem Mol Morphol 2012;20:82-90
27. Wang S, Sorenson CM, Sheibani N: Lack of thrombospondin 1 and exacerbation of choroidal neovascularization. Arch Ophthalmol 2012;130:615-620
28. Hulley SB, Cummings SR, Browner WS, Grady DG, Newman TB (editors): Estimating sample size and power: Applications and examples. In Designing Clinical Research: An Epidemiologic Approach. 3rd edition. Philadelphia, Lippincott Williams & Wilkins, 2006, pp 65-94
29. Zou KH, Tuncali K, Silverman SG: Correlation and simple linear regression. Radiology 2003;227:617-622
30. Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307-310
31. Miller PB, Parnell BA, Bushnell G, Tallman N, Forstein DA, Higdon HL 3rd, Kitawaki J, Lessey BA: Endometrial receptivity defects during IVF cycles with and without letrozole. Hum Reprod 2012;27:881-888