Development and validation of a sensitive method for simultaneous determination of rosuvastatin and N-desmethyl rosuvastatin in human plasma using liquid chromatography/negative electrospray ionization/tandem mass spectrometry

Biomedical Chromatography

Volumn 27, Issue 11, 2013, Pages 1369-1374

  Lee, H K ^a   Ho, C S ^a   Hu, M ^a   Tomlinson, B ^a   Wong, C K ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

HMG CoA reductase inhibitor; LC MS; N desmethyl rosuvastatin; Pharmacokinetics; Rosuvastatin

Indexed keywords

ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PLASMA (HUMAN);

ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; HMG-COA REDUCTASE INHIBITOR; HUMAN PLASMAS; LC/MS; N-DESMETHYL ROSUVASTATIN; NEGATIVE ELECTROSPRAY IONIZATIONS; PLASMA SAMPLES; ROSUVASTATIN; SENSITIVE METHOD; SIMULTANEOUS DETERMINATIONS;

PHARMACOKINETICS;

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; N DESMETHYL ROSUVASTATIN; ROSUVASTATIN; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NORMAL HUMAN; PLASMA; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

HMG-COA REDUCTASE INHIBITOR; LC/MS; N-DESMETHYL ROSUVASTATIN; PHARMACOKINETICS; ROSUVASTATIN;

CHROMATOGRAPHY, LIQUID; FLUOROBENZENES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIMIT OF DETECTION; PYRIMIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

EID: 84885905736     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2944     Document Type: Article

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