A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Analytical and Bioanalytical Chemistry

Volumn 402, Issue 3, 2012, Pages 1217-1227

  MacWan, Joyce S ^a   Ionita, Ileana A ^a   Akhlaghi, Fatemeh ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Assay; Lactone; LC MS MS; N Desmethyl; Pharmacokinetics; Protein precipitation; Rosuvastatin

Indexed keywords

LACTONE; LC-MS/MS; N-DESMETHYL; PROTEIN PRECIPITATION; ROSUVASTATIN;

ACETIC ACID; ACETONITRILE; ASSAYS; DEUTERIUM; ELECTROSPRAY IONIZATION; LIQUIDS; MASS SPECTROMETRY; METHANOL; ORGANIC SOLVENTS; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS;

LIQUID CHROMATOGRAPHY;

FLUOROBENZENE; LACTONE; N DESMETHYLROSUVASTATIN; N-DESMETHYLROSUVASTATIN; PYRIMIDINE DERIVATIVE; ROSUVASTATIN; ROSUVASTATIN LACTONE; SULFONAMIDE;

ARTICLE; BLOOD; ECONOMICS; HUMAN; LIQUID CHROMATOGRAPHY; METHODOLOGY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, LIQUID; FLUOROBENZENES; HUMANS; LACTONES; PYRIMIDINES; SENSITIVITY AND SPECIFICITY; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

EID: 84856215633     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5548-4     Document Type: Article

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