Celiac disease patients presenting with anemia have more severe disease than those presenting with diarrhea

Clinical Gastroenterology and Hepatology

Volumn 11, Issue 11, 2013, Pages 1472-1477

  Abu Daya, Hussein ^a   Lebwohl, Benjamin ^a   Lewis, Suzanne K ^a   Green, Peter H ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

BMD; Gluten; HDL; Iron Deficiency

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ADULT; ANEMIA; ARTICLE; BONE DENSITY; CELIAC DISEASE; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DIARRHEA; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; ENZYME BLOOD LEVEL; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; INTESTINE VILLUS ATROPHY; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE;

ANTI-TTG; BMD; BMI; BODY MASS INDEX; BONE MINERAL DENSITY; CD; CELIAC DISEASE; CI; CONFIDENCE INTERVAL; ERYTHROCYTE SEDIMENTATION RATE; ESR; GLUTEN; HCT; HDL; HEMATOCRIT; HIGH-DENSITY LIPOPROTEIN; IRON DEFICIENCY; LDL; LOW-DENSITY LIPOPROTEIN; ODDS RATIO; OR; PARTIAL VILLOUS ATROPHY; PVA; S/TVA; SUBTOTAL/TOTAL VILLOUS ATROPHY; TC; TG; TISSUE TRANSGLUTAMINASE ANTIBODY; TOTAL CHOLESTEROL; TOTAL VILLOUS ATROPHY; TRIGLYCERIDES; TVA;

ADULT; AGED; ANEMIA; AUTOANTIBODIES; BLOOD SEDIMENTATION; BONE DENSITY; CELIAC DISEASE; CHOLESTEROL; COHORT STUDIES; DIARRHEA; FEMALE; GTP-BINDING PROTEINS; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SEX FACTORS; TRANSGLUTAMINASES;

EID: 84885869810     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.05.030     Document Type: Article

References (41)

1. Green P.H., Jabri B. Coeliac disease. Lancet 2003, 362:383-391.
2. Fasano A., Berti I., Gerarduzzi T., et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003, 163:286-292.
3. West J., Logan R.F., Hill P.G., et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 2003, 52:960-965.
4. Bai D., Brar P., Holleran S., et al. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol 2005, 40:183-187.
5. Rampertab S.D., Pooran N., Brar P., et al. Trends in the presentation of celiac disease. Am J Med 2006, 119:355.
6. Harper J.W., Holleran S.F., Ramakrishnan R., et al. Anemia in celiac disease is multifactorial in etiology. Am J Hematol 2007, 82:996-1000.
7. Bottaro G., Cataldo F., Rotolo N., et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol 1999, 94:691-696.
8. Bode S., Gudmand-Hoyer E. Symptoms and haematologic features in consecutive adult coeliac patients. Scand J Gastroenterol 1996, 31:54-60.
9. Green P.H., Cellier C. Celiac disease. NEngl J Med 2007, 357:1731-1743.
10. Dahlbom I., Korponay-Szabo I.R., Kovacs J.B., et al. Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase. JPediatr Gastroenterol Nutr 2010, 50:140-146.
11. Taavela J., Kurppa K., Collin P., et al. Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease. Clin Gastroenterol Hepatol 2013, 11:166-171.
12. Thomas H.J., Ahmad T., Rajaguru C., et al. Contribution of histological, serological, and genetic factors to the clinical heterogeneity of adult-onset coeliac disease. Scand J Gastroenterol 2009, 44:1076-1083.
13. Zanini B., Caselani F., Magni A., et al. Celiac disease with mild enteropathy is not mild disease. Clin Gastroenterol Hepatol 2013, 11:253-258.
14. Jatla M., Bokhari A., Bierly P., et al. Anthropometric, serologic, and laboratory correlation with villous blunting in pediatric celiac disease: diabetics are different. JClin Gastroenterol 2009, 43:622-626.
15. Jores R.D., Frau F., Cucca F., et al. HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease. Scand J Gastroenterol 2007, 42:48-53.
16. Karinen H., Karkkainen P., Pihlajamaki J., et al. Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease. Scand J Gastroenterol 2006, 41:191-199.
17. Brar P., Kwon G.Y., Egbuna, et al. Lack of correlation of degree of villous atrophy with severity of clinical presentation of coeliac disease. Digestive and Liver Disease 2007, 39:26-32.
18. Murray J.A., Moore S.B., Van Dyke C.T., et al. HLA DQ gene dosage and risk and severity of celiac disease. Clin Gastroenterol Hepatol 2007, 5:1406-1412.
19. Murray J.A., Rubio-Tapia A., Van Dyke C.T., et al. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment. Clin Gastroenterol Hepatol 2008, 6:186-193. quiz 25.
20. Best W.R., Becktel J.M., Singleton J.W., et al. Development of a Crohn's disease activity index: National Cooperative Crohn's Disease Study. Gastroenterology 1976, 70:439-444.
21. Lo W., Sano K., Lebwohl B., et al. Changing presentation of adult celiac disease. Dig Dis Sci 2003, 48:395-398.
22. WHO, UNICEF, UNU. Iron deficiency anaemia: assessment, prevention and control, a guide for programme managers. Geneva: World Health Organization, 2001. Available at: Accessed February 13, 2013. http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/WHO_NHD_01.3/en/index.html.
23. Oberhuber G., Granditsch G., Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999, 11:1185-1194.
24. Hill P.G., Holmes G.K. Coeliac disease: a biopsy is not always necessary for diagnosis. Aliment Pharmacol Ther 2008, 27:572-577.
25. Alessio M.G., Tonutti E., Brusca I., et al. Correlation between IgA tissue transglutaminase antibody ratio and histological finding in celiac disease. JPediatr Gastroenterol Nutr 2012, 55:44-49.
26. Leffler D.A., Dennis M., Edwards George J., et al. Avalidated disease-specific symptom index for adults with celiac disease. Clin Gastroenterol Hepatol 2009, 7:1328-1334.
27. Dorn S.D., Hernandez L., Minaya M.T., et al. The development and validation of a new coeliac disease quality of life survey (CD-QOL). Aliment Pharmacol Ther 2010, 31:666-675.
28. Zanini B., Magni A., Caselani F., et al. High tissue-transglutaminase antibody level predicts small intestinal villous atrophy in adult patients at high risk of celiac disease. Digestive and Liver Disease 2012, 44:280-285.
29. Weizman Z., Ben-Zion Y.Z., Binsztok M., et al. Correlation of clinical characteristics and small bowel histopathology in celiac disease. JPediatr Gastroenterol Nutr 1997, 24:555-558.
30. Licata A., Cappello M., Arini A., et al. Serology in adults with celiac disease: limited accuracy in patients with mild histological lesions. Intern Emerg Med 2012, 7:337-342.
31. Donaldson M.R., Book L.S., Leiferman K.M., et al. Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease. JClin Gastroenterol 2008, 42:256-260.
32. Tursi A., Brandimarte G., Giorgetti G.M. Prevalence of antitissue transglutaminase antibodies in different degrees of intestinal damage in celiac disease. JClin Gastroenterol 2003, 36:219-221.
33. Biagi F., Bianchi P.I., Vattiato C., et al. Influence of HLA-DQ2 and DQ8 on severity in celiac disease. JClin Gastroenterol 2012, 46:46-50.
34. Abrams J.A., Brar P., Diamond B., et al. Utility in clinical practice of immunoglobulin a anti-tissue transglutaminase antibody for the diagnosis of celiac disease. Clin Gastroenterol Hepatol 2006, 4:726-730.
35. Ciacci C., Cirillo M., Giorgetti G., et al. Low plasma cholesterol: a correlate of nondiagnosed celiac disease in adults with hypochromic anemia. Am J Gastroenterol 1999, 94:1888-1891.
36. Capristo E., Addolorato G., Mingrone G., et al. Low-serum high-density lipoprotein-cholesterol concentration as a sign of celiac disease. Am J Gastroenterol 2000, 95:3331-3332.
37. Brar P., Kwon G.Y., Holleran S., et al. Change in lipid profile in celiac disease: beneficial effect of gluten-free diet. Am J Med 2006, 119:786-790.
38. Vuoristo M., Miettinen T.A. Increased biliary lipid secretion in celiac disease. Gastroenterology 1985, 88(Pt 1):134-142.
39. Glickman R.M., Green P.H., Lees R.S., et al. Apoprotein A-I synthesis in normal intestinal mucosa and in Tangier disease. NEngl J Med 1978, 299:1424-1427.
40. Lewis N.R., Sanders D.S., Logan R.F., et al. Cholesterol profile in people with newly diagnosed coeliac disease: a comparison with the general population and changes following treatment. Br J Nutr 2009, 102:509-513.
41. Dorn S.D., Hernandez L., Minaya M.T., et al. Psychosocial factors are more important than disease activity in determining gastrointestinal symptoms and health status in adults at a celiac disease referral center. Dig Dis Sci 2010, 55:3154-3163.