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Volumn 62, Issue 10, 2013, Pages 1599-1608

AE37 peptide vaccination in prostate cancer: A 4-year immunological assessment updates on a phase i trial

Author keywords

AE37 vaccine; HER 2 neu; Immunological memory; Prostate cancer

Indexed keywords

AE36 PEPTIDE; AE37 PEPTIDE; CANCER VACCINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VACCINE;

EID: 84885859512     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1461-3     Document Type: Article
Times cited : (28)

References (43)
  • 1
    • 77954939175 scopus 로고    scopus 로고
    • Prostate cancer as a model for tumour immunotherapy
    • 10.1038/nri2817 20651745 10.1038/nri2817 1:CAS:528:DC%2BC3cXpt1Gju78%3D
    • Drake CG (2010) Prostate cancer as a model for tumour immunotherapy. Nat Rev Immunol 10:580-593. doi: 10.1038/nri2817
    • (2010) Nat Rev Immunol , vol.10 , pp. 580-593
    • Drake, C.G.1
  • 4
    • 0034833701 scopus 로고    scopus 로고
    • Her-2/neu expression in prostate cancer: High level of expression associated with exposure to hormone therapy and androgen independent disease
    • 11547123 10.1016/S0022-5347(05)65822-3 1:CAS:528:DC%2BD3MXptVKksLg%3D
    • Shi Y, Brands FH, Chatterjee S, Feng AC, Groshen S, Schewe J, Lieskovsky G, Cote RJ (2001) Her-2/neu expression in prostate cancer: high level of expression associated with exposure to hormone therapy and androgen independent disease. J Urol 166:1514-1519
    • (2001) J Urol , vol.166 , pp. 1514-1519
    • Shi, Y.1    Brands, F.H.2    Chatterjee, S.3    Feng, A.C.4    Groshen, S.5    Schewe, J.6    Lieskovsky, G.7    Cote, R.J.8
  • 5
    • 0034614108 scopus 로고    scopus 로고
    • Her-2-neu expression and progression toward androgen independence in human prostate cancer
    • 11106683 10.1093/jnci/92.23.1918 1:CAS:528:DC%2BD3cXptVehu7Y%3D
    • Signoretti S, Montironi R, Manola J et al (2000) Her-2-neu expression and progression toward androgen independence in human prostate cancer. J Natl Cancer Inst 92:1918-1925
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1918-1925
    • Signoretti, S.1    Montironi, R.2    Manola, J.3
  • 6
    • 33947594043 scopus 로고    scopus 로고
    • Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy
    • 10.1200/JCO.2006.07.0649 10.1200/JCO.2006.07.0649 1:CAS:528: DC%2BD2sXjt1Kgu7k%3D
    • Agus DB, Sweeney CJ, Morris MJ et al (2007) Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy. J Clin Oncolo Off J Am Soc Clin Oncol 25:675-681. doi: 10.1200/JCO.2006.07.0649
    • (2007) J Clin Oncolo off J Am Soc Clin Oncol , vol.25 , pp. 675-681
    • Agus, D.B.1    Sweeney, C.J.2    Morris, M.J.3
  • 7
    • 33846927744 scopus 로고    scopus 로고
    • Open-label phase II study evaluating the efficacy and safety of two doses of pertuzumab in castrate chemotherapy-naive patients with hormone-refractory prostate cancer
    • 10.1200/JCO.2006.07.0888 10.1200/JCO.2006.07.0888
    • de Bono JS, Bellmunt J, Attard G et al (2007) Open-label phase II study evaluating the efficacy and safety of two doses of pertuzumab in castrate chemotherapy-naive patients with hormone-refractory prostate cancer. J Clin Oncol Off J Am Soc Clin Oncol 25:257-262. doi: 10.1200/JCO.2006.07.0888
    • (2007) J Clin Oncol off J Am Soc Clin Oncol , vol.25 , pp. 257-262
    • De Bono, J.S.1    Bellmunt, J.2    Attard, G.3
  • 9
    • 0035900806 scopus 로고    scopus 로고
    • Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope
    • 10.1054/bjoc.2001.2089 11720440 10.1054/bjoc.2001.2089 1:CAS:528:DC%2BD38XkslemtQ%3D%3D
    • Sotiriadou R, Perez SA, Gritzapis AD et al (2001) Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope. Br J Cancer 85:1527-1534. doi: 10.1054/bjoc.2001.2089
    • (2001) Br J Cancer , vol.85 , pp. 1527-1534
    • Sotiriadou, R.1    Perez, S.A.2    Gritzapis, A.D.3
  • 10
    • 2542421142 scopus 로고    scopus 로고
    • Ii-Key/HER-2/neu MHC class-II antigenic epitope vaccine peptide for breast cancer
    • 10.1007/s00262-003-0463-y 10.1007/s00262-003-0463-y 1:CAS:528: DC%2BD2cXjs1Kjs7o%3D
    • Gillogly ME, Kallinteris NL, Xu M, Gulfo JV, Humphreys RE, Murray JL (2004) Ii-Key/HER-2/neu MHC class-II antigenic epitope vaccine peptide for breast cancer. Cancer immunol immunotherapy CII 53:490-496. doi: 10.1007/s00262-003-0463-y
    • (2004) Cancer Immunol Immunotherapy CII , vol.53 , pp. 490-496
    • Gillogly, M.E.1    Kallinteris, N.L.2    Xu, M.3    Gulfo, J.V.4    Humphreys, R.E.5    Murray, J.L.6
  • 11
    • 77951454087 scopus 로고    scopus 로고
    • A new era in anticancer peptide vaccines
    • Perez SA, von Hofe E, Kallinteris NL, Gritzapis AD, Peoples GE, Papamichail M, Baxevanis CN 10.1002/cncr.24988
    • Perez SA, von Hofe E, Kallinteris NL, Gritzapis AD, Peoples GE, Papamichail M, Baxevanis CN (2010) A new era in anticancer peptide vaccines. Cancer 116:2071-2080. doi: 10.1002/cncr.24988
    • (2010) Cancer , vol.116 , pp. 2071-2080
  • 12
    • 33847405324 scopus 로고    scopus 로고
    • Ii-Key/HER-2/neu(776-790) hybrid peptides induce more effective immunological responses over the native peptide in lymphocyte cultures from patients with HER-2/neu + tumors
    • 10.1007/s00262-006-0213-z 10.1007/s00262-006-0213-z 1:CAS:528: DC%2BD2sXisVaqtbs%3D
    • Sotiriadou NN, Kallinteris NL, Gritzapis AD et al (2007) Ii-Key/HER-2/neu(776-790) hybrid peptides induce more effective immunological responses over the native peptide in lymphocyte cultures from patients with HER-2/neu + tumors. Cancer Immunol Immunother CII 56:601-613. doi: 10.1007/s00262-006-0213-z
    • (2007) Cancer Immunol Immunother CII , vol.56 , pp. 601-613
    • Sotiriadou, N.N.1    Kallinteris, N.L.2    Gritzapis, A.D.3
  • 13
    • 34648833468 scopus 로고    scopus 로고
    • Induction of potent CD4 + T cell-mediated antitumor responses by a helper HER-2/neu peptide linked to the Ii-Key moiety of the invariant chain
    • 10.1002/ijc.22936 17634957 10.1002/ijc.22936 1:CAS:528:DC%2BD2sXhtFSjsLzN
    • Voutsas IF, Gritzapis AD, Mahaira LG, Salagianni M, von Hofe E, Kallinteris NL, Baxevanis CN (2007) Induction of potent CD4 + T cell-mediated antitumor responses by a helper HER-2/neu peptide linked to the Ii-Key moiety of the invariant chain. Int J Cancer 121:2031-2041. doi: 10.1002/ijc.22936
    • (2007) Int J Cancer , vol.121 , pp. 2031-2041
    • Voutsas, I.F.1    Gritzapis, A.D.2    Mahaira, L.G.3    Salagianni, M.4    Von Hofe, E.5    Kallinteris, N.L.6    Baxevanis, C.N.7
  • 14
    • 77954235468 scopus 로고    scopus 로고
    • Results from a phase i clinical study of the novel Ii-Key/HER-2/neu(776- 790) hybrid peptide vaccine in patients with prostate cancer
    • 10.1158/1078-0432.CCR-10-0085 10.1158/1078-0432.CCR-10-0085 1:CAS:528:DC%2BC3cXot1Wltrc%3D
    • Perez SA, Kallinteris NL, Bisias S et al (2010) Results from a phase I clinical study of the novel Ii-Key/HER-2/neu(776-790) hybrid peptide vaccine in patients with prostate cancer. Clin Cancer Res Off J Am Assoc Cancer Res 16:3495-3506. doi: 10.1158/1078-0432.CCR-10-0085
    • (2010) Clin Cancer Res off J Am Assoc Cancer Res , vol.16 , pp. 3495-3506
    • Perez, S.A.1    Kallinteris, N.L.2    Bisias, S.3
  • 15
    • 79251595590 scopus 로고    scopus 로고
    • Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers
    • 10.1016/j.imbio.2010.07.010 20822828 10.1016/j.imbio.2010.07.010 1:CAS:528:DC%2BC3MXhtlamu7o%3D
    • Sperner-Unterweger B, Neurauter G, Klieber M, Kurz K, Meraner V, Zeimet A, Fuchs D (2011) Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers. Immunobiology 216:296-301. doi: 10.1016/j.imbio.2010.07.010
    • (2011) Immunobiology , vol.216 , pp. 296-301
    • Sperner-Unterweger, B.1    Neurauter, G.2    Klieber, M.3    Kurz, K.4    Meraner, V.5    Zeimet, A.6    Fuchs, D.7
  • 16
    • 0031451315 scopus 로고    scopus 로고
    • Simultaneous measurement of serum tryptophan and kynurenine by HPLC
    • 9439467 1:CAS:528:DyaK1cXis1KltA%3D%3D
    • Widner B, Werner ER, Schennach H, Wachter H, Fuchs D (1997) Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 43:2424-2426
    • (1997) Clin Chem , vol.43 , pp. 2424-2426
    • Widner, B.1    Werner, E.R.2    Schennach, H.3    Wachter, H.4    Fuchs, D.5
  • 17
    • 0033526309 scopus 로고    scopus 로고
    • Natural history of progression after PSA elevation following radical prostatectomy
    • 10.1001/jama.281.17.1591 1:STN:280:DyaK1M3kvFagsg%3D%3D
    • Pound CR, Partin AW, Eisenberger MA, Chan DW, Pearson JD, Walsh PC (1999) Natural history of progression after PSA elevation following radical prostatectomy. JAMA J Am Med Assoc 281:1591-1597
    • (1999) JAMA J Am Med Assoc , vol.281 , pp. 1591-1597
    • Pound, C.R.1    Partin, A.W.2    Eisenberger, M.A.3    Chan, D.W.4    Pearson, J.D.5    Walsh, P.C.6
  • 18
    • 79957879852 scopus 로고    scopus 로고
    • PROVENGE (Sipuleucel-T) in prostate cancer: The first FDA-approved therapeutic cancer vaccine
    • 10.1158/1078-0432.CCR-10-3126 10.1158/1078-0432.CCR-10-3126
    • Cheever MA, Higano CS (2011) PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine. Clin Cancer Res Off J Am Assoc Cancer Res 17:3520-3526. doi: 10.1158/1078-0432.CCR-10-3126
    • (2011) Clin Cancer Res off J Am Assoc Cancer Res , vol.17 , pp. 3520-3526
    • Cheever, M.A.1    Higano, C.S.2
  • 20
    • 80052204537 scopus 로고    scopus 로고
    • Combination therapy: Abiraterone prolongs survival in metastatic prostate cancer
    • 10.1038/nrclinonc.2011.111 21808270 10.1038/nrclinonc.2011.111 1:CAS:528:DC%2BC3MXhtFWlur%2FO
    • Sartor O (2011) Combination therapy: abiraterone prolongs survival in metastatic prostate cancer. Nat Rev Clin Oncol 8:515-516. doi: 10.1038/nrclinonc.2011.111
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 515-516
    • Sartor, O.1
  • 21
    • 22144439081 scopus 로고    scopus 로고
    • Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
    • 10.1007/s00262-004-0653-2 10.1007/s00262-004-0653-2 1:CAS:528: DC%2BD2MXmtVajt78%3D
    • Knutson KL, Disis ML (2005) Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Cancer Immunol Immunother CII 54:721-728. doi: 10.1007/s00262-004-0653-2
    • (2005) Cancer Immunol Immunother CII , vol.54 , pp. 721-728
    • Knutson, K.L.1    Disis, M.L.2
  • 22
    • 42549138499 scopus 로고    scopus 로고
    • Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
    • 10.1038/nrc2373 18418403 10.1038/nrc2373 1:CAS:528:DC%2BD1cXltVGlur0%3D
    • Melief CJ, van der Burg SH (2008) Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines. Nat Rev Cancer 8:351-360. doi: 10.1038/nrc2373
    • (2008) Nat Rev Cancer , vol.8 , pp. 351-360
    • Melief, C.J.1    Van Der Burg, S.H.2
  • 23
    • 84868108564 scopus 로고    scopus 로고
    • A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma
    • 10.1371/journal.pone.0048424 23110239 10.1371/journal.pone.0048424 1:CAS:528:DC%2BC38Xhs1yrtb7K
    • Ebert LM, MacRaild SE, Zanker D, Davis ID, Cebon J, Chen W (2012) A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma. PLoS ONE 7:e48424. doi: 10.1371/journal.pone. 0048424
    • (2012) PLoS ONE , vol.7 , pp. 48424
    • Ebert, L.M.1    Macraild, S.E.2    Zanker, D.3    Davis, I.D.4    Cebon, J.5    Chen, W.6
  • 24
    • 66249115337 scopus 로고    scopus 로고
    • The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells
    • 10.1158/0008-5472.CAN-08-3726 19435913 10.1158/0008-5472.CAN-08-3726 1:CAS:528:DC%2BD1MXlvFWltbw%3D
    • Francois V, Ottaviani S, Renkvist N et al (2009) The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells. Cancer Res 69:4335-4345. doi: 10.1158/0008-5472.CAN-08-3726
    • (2009) Cancer Res , vol.69 , pp. 4335-4345
    • Francois, V.1    Ottaviani, S.2    Renkvist, N.3
  • 25
    • 40549110815 scopus 로고    scopus 로고
    • Induction of tumor-specific CD4 + and CD8 + T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine
    • 10.1158/1078-0432.CCR-07-1880 10.1158/1078-0432.CCR-07-1880 1:CAS:528:DC%2BD1cXoslGh
    • Welters MJ, Kenter GG, Piersma SJ et al (2008) Induction of tumor-specific CD4 + and CD8 + T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine. Clin Cancer Res Off J Am Assoc Cancer Res 14:178-187. doi: 10.1158/1078-0432.CCR-07-1880
    • (2008) Clin Cancer Res off J Am Assoc Cancer Res , vol.14 , pp. 178-187
    • Welters, M.J.1    Kenter, G.G.2    Piersma, S.J.3
  • 26
    • 77952197527 scopus 로고    scopus 로고
    • Monitoring of NY-ESO-1 specific CD4 + T cells using molecularly defined MHC class II/His-tag-peptide tetramers
    • 10.1073/pnas.1001322107 20368442 10.1073/pnas.1001322107 1:CAS:528:DC%2BC3cXlsFWhsb8%3D
    • Ayyoub M, Dojcinovic D, Pignon P, Raimbaud I, Schmidt J, Luescher I, Valmori D (2010) Monitoring of NY-ESO-1 specific CD4 + T cells using molecularly defined MHC class II/His-tag-peptide tetramers. Proc Natl Acad Sci USA 107:7437-7442. doi: 10.1073/pnas.1001322107
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7437-7442
    • Ayyoub, M.1    Dojcinovic, D.2    Pignon, P.3    Raimbaud, I.4    Schmidt, J.5    Luescher, I.6    Valmori, D.7
  • 27
    • 68249133652 scopus 로고    scopus 로고
    • Pretreatment frequency of circulating IL-17 + CD4 + T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients
    • 10.1002/ijc.24497 19533748 10.1002/ijc.24497 1:CAS:528: DC%2BD1MXovVelsrg%3D
    • Derhovanessian E, Adams V, Hahnel K, Groeger A, Pandha H, Ward S, Pawelec G (2009) Pretreatment frequency of circulating IL-17 + CD4 + T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int J Cancer 125:1372-1379. doi: 10.1002/ijc.24497
    • (2009) Int J Cancer , vol.125 , pp. 1372-1379
    • Derhovanessian, E.1    Adams, V.2    Hahnel, K.3    Groeger, A.4    Pandha, H.5    Ward, S.6    Pawelec, G.7
  • 28
    • 70350127838 scopus 로고    scopus 로고
    • Tumor antigen-specific FOXP3 + CD4 T cells identified in human metastatic melanoma: Peptide vaccination results in selective expansion of Th1-like counterparts
    • 10.1158/0008-5472.CAN-09-2226 19808957 10.1158/0008-5472.CAN-09-2226 1:CAS:528:DC%2BD1MXht1ynurfE
    • Jandus C, Bioley G, Dojcinovic D et al (2009) Tumor antigen-specific FOXP3 + CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts. Cancer Res 69:8085-8093. doi: 10.1158/0008-5472.CAN-09-2226
    • (2009) Cancer Res , vol.69 , pp. 8085-8093
    • Jandus, C.1    Bioley, G.2    Dojcinovic, D.3
  • 29
    • 77958196145 scopus 로고    scopus 로고
    • Circulating regulatory T cells (CD4+ CD25+ FOXP3+) decrease in breast cancer patients after vaccination with a modified MHC class II HER2/neu (AE37) peptide
    • 10.1016/j.vaccine.2010.09.029 20858449 10.1016/j.vaccine.2010.09.029 1:CAS:528:DC%2BC3cXhtlenu7zN
    • Gates JD, Clifton GT, Benavides LC et al (2010) Circulating regulatory T cells (CD4+ CD25+ FOXP3+) decrease in breast cancer patients after vaccination with a modified MHC class II HER2/neu (AE37) peptide. Vaccine 28:7476-7482. doi: 10.1016/j.vaccine.2010.09.029
    • (2010) Vaccine , vol.28 , pp. 7476-7482
    • Gates, J.D.1    Clifton, G.T.2    Benavides, L.C.3
  • 30
    • 84877076923 scopus 로고    scopus 로고
    • From the immune contexture to the Immunoscore: The role of prognostic and predictive immune markers in cancer
    • 10.1016/j.coi.2013.03.004 23579076 10.1016/j.coi.2013.03.004 1:CAS:528:DC%2BC3sXls1SntL8%3D
    • Angell H, Galon J (2013) From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer. Curr Opin Immunol 25:261-267. doi: 10.1016/j.coi.2013.03.004
    • (2013) Curr Opin Immunol , vol.25 , pp. 261-267
    • Angell, H.1    Galon, J.2
  • 31
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: Impact on clinical outcome
    • 10.1038/nrc3245 22419253 10.1038/nrc3245 1:CAS:528:DC%2BC38Xjslersb4%3D
    • Fridman WH, Pages F, Sautes-Fridman C, Galon J (2012) The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 12:298-306. doi: 10.1038/nrc3245
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3    Galon, J.4
  • 32
    • 84875744038 scopus 로고    scopus 로고
    • High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer
    • 10.1016/j.ejca.2012.11.035 23266046 10.1016/j.ejca.2012.11.035 1:CAS:528:DC%2BC38XhvFWhurnF
    • Flammiger A, Weisbach L, Huland H et al (2013) High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer. Eur J Cancer 49:1273-1279. doi: 10.1016/j.ejca.2012.11.035
    • (2013) Eur J Cancer , vol.49 , pp. 1273-1279
    • Flammiger, A.1    Weisbach, L.2    Huland, H.3
  • 33
    • 84877807450 scopus 로고    scopus 로고
    • Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer
    • 10.1002/ijc.28026 23319273
    • Huen NY, Pang AL, Tucker JA et al (2013) Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer. Int J Cancer. doi: 10.1002/ijc.28026
    • (2013) Int J Cancer
    • Huen, N.Y.1    Pang, A.L.2    Tucker, J.A.3
  • 34
    • 77950473925 scopus 로고    scopus 로고
    • Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer
    • 10.1007/s00262-009-0782-8 10.1007/s00262-009-0782-8 1:CAS:528: DC%2BC3cXis1yhtr8%3D
    • Gulley JL, Arlen PM, Madan RA et al (2010) Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer. Cancer Immunol Immunother CII 59:663-674. doi: 10.1007/s00262-009-0782-8
    • (2010) Cancer Immunol Immunother CII , vol.59 , pp. 663-674
    • Gulley, J.L.1    Arlen, P.M.2    Madan, R.A.3
  • 35
    • 39149129661 scopus 로고    scopus 로고
    • Peripheral T-cell tolerance associated with prostate cancer is independent from CD4+ CD25+ regulatory T cells
    • 10.1158/0008-5472.CAN-07-2429 18172322 10.1158/0008-5472.CAN-07-2429
    • Degl'Innocenti E, Grioni M, Capuano G, Jachetti E, Freschi M, Bertilaccio MT, Hess-Michelini R, Doglioni C, Bellone M (2008) Peripheral T-cell tolerance associated with prostate cancer is independent from CD4+ CD25+ regulatory T cells. Cancer Res 68:292-300. doi: 10.1158/0008-5472.CAN-07-2429
    • (2008) Cancer Res , vol.68 , pp. 292-300
    • Degl'Innocenti, E.1    Grioni, M.2    Capuano, G.3    Jachetti, E.4    Freschi, M.5    Bertilaccio, M.T.6    Hess-Michelini, R.7    Doglioni, C.8    Bellone, M.9
  • 36
    • 35748966479 scopus 로고    scopus 로고
    • 'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation
    • 10.1111/j.1600-065X.2007.00565.x 17979848 10.1111/j.1600-065X.2007.00565. x 1:CAS:528:DC%2BD2sXhsVKgtrvP
    • Wan YY, Flavell RA (2007) 'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev 220:199-213. doi: 10.1111/j.1600-065X.2007.00565.x
    • (2007) Immunol Rev , vol.220 , pp. 199-213
    • Wan, Y.Y.1    Flavell, R.A.2
  • 37
    • 77956220086 scopus 로고    scopus 로고
    • TGF-beta induces IL-9 production from human Th17 cells
    • 10.4049/jimmunol.1000356 20498357 10.4049/jimmunol.1000356 1:CAS:528:DC%2BC3cXns1CqsLs%3D
    • Beriou G, Bradshaw EM, Lozano E et al (2010) TGF-beta induces IL-9 production from human Th17 cells. J Immunol 185:46-54. doi: 10.4049/jimmunol. 1000356
    • (2010) J Immunol , vol.185 , pp. 46-54
    • Beriou, G.1    Bradshaw, E.M.2    Lozano, E.3
  • 38
    • 84868611628 scopus 로고    scopus 로고
    • Th9 cells promote antitumor immune responses in vivo
    • 10.1172/JCI65459 23064366 10.1172/JCI65459 1:CAS:528:DC%2BC38Xhs1CisL%2FE
    • Lu Y, Hong S, Li H et al (2012) Th9 cells promote antitumor immune responses in vivo. J Clin Invest 122:4160-4171. doi: 10.1172/JCI65459
    • (2012) J Clin Invest , vol.122 , pp. 4160-4171
    • Lu, Y.1    Hong, S.2    Li, H.3
  • 39
    • 16444374110 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation
    • 10.1111/j.1365-2567.2005.02115.x 15804285 10.1111/j.1365-2567.2005.02115. x 1:CAS:528:DC%2BD2MXjtFeqtLc%3D
    • Smeltz RB, Chen J, Shevach EM (2005) Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation. Immunology 114:484-492. doi: 10.1111/j.1365-2567.2005.02115.x
    • (2005) Immunology , vol.114 , pp. 484-492
    • Smeltz, R.B.1    Chen, J.2    Shevach, E.M.3
  • 40
    • 84874101369 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling controls activities of human intestinal CD8(+)T suppressor cells
    • 10.1053/j.gastro.2012.12.001 23232296
    • Rabinowitz KM, Wang Y, Chen EY et al (2013) Transforming growth factor beta signaling controls activities of human intestinal CD8(+)T suppressor cells. Gastroenterology 144(601-12):e1. doi: 10.1053/j.gastro.2012.12.001
    • (2013) Gastroenterology , vol.144 , Issue.601-612 , pp. 1
    • Rabinowitz, K.M.1    Wang, Y.2    Chen, E.Y.3
  • 41
    • 67651005826 scopus 로고    scopus 로고
    • Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer
    • 10.1172/JCI37480 19451693 10.1172/JCI37480 1:CAS:528:DC%2BD1MXntVCjt7c%3D
    • Bierie B, Chung CH, Parker JS, Stover DG, Cheng N, Chytil A, Aakre M, Shyr Y, Moses HL (2009) Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. J Clin Invest 119:1571-1582. doi: 10.1172/JCI37480
    • (2009) J Clin Invest , vol.119 , pp. 1571-1582
    • Bierie, B.1    Chung, C.H.2    Parker, J.S.3    Stover, D.G.4    Cheng, N.5    Chytil, A.6    Aakre, M.7    Shyr, Y.8    Moses, H.L.9
  • 42
    • 76249093444 scopus 로고    scopus 로고
    • Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance
    • 10.4049/jimmunol.0901004 19933867 10.4049/jimmunol.0901004 1:CAS:528:DC%2BD1MXhsFCkt7rF
    • Godin-Ethier J, Pelletier S, Hanafi LA et al (2009) Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance. J Immunol 183:7752-7760. doi: 10.4049/jimmunol.0901004
    • (2009) J Immunol , vol.183 , pp. 7752-7760
    • Godin-Ethier, J.1    Pelletier, S.2    Hanafi, L.A.3
  • 43
    • 84880279552 scopus 로고    scopus 로고
    • Combination checkpoint blockade: Taking melanoma immunotherapy to the next level
    • 10.1056/NEJMe1305484
    • Riley JL (2013) Combination checkpoint blockade: taking melanoma immunotherapy to the next level. The New England journal of medicine. doi: 10.1056/NEJMe1305484
    • (2013) The New England Journal of Medicine
    • Riley, J.L.1


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