A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: Effects on subjective and objective sleepiness and cognitive function

Journal of Biological Rhythms

Volumn 28, Issue 5, 2013, Pages 306-321

  Wilhelmsen Langeland, Ane ^a,b   Saxvig, Ingvild W ^a,b   Pallesen, Ståle ^a,b   Nordhus, Inger Hilde ^a,b   Vedaa, Øystein ^c   Lundervold, Astri J ^a   Bjorvatn, Bjørn ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

bright light; circadian rhythms; daytime function; delayed sleep phase disorder; melatonin; randomized controlled trial; treatment

Indexed keywords

MELATONIN; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; BRIGHT LIGHT; CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SLEEP DISORDER; CIRCADIAN RHYTHMS; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAYTIME FUNCTION; DELAYED SLEEP PHASE DISORDER; DOUBLE BLIND PROCEDURE; FATIGUE; FEMALE; HUMAN; MALE; NORWAY; PATHOPHYSIOLOGY; PATIENT COMPLIANCE; PHOTOTHERAPY; PSYCHOLOGICAL ASPECT; RANDOMIZED CONTROLLED TRIAL; TREATMENT; YOUNG ADULT;

BRIGHT LIGHT; CIRCADIAN RHYTHMS; DAYTIME FUNCTION; DELAYED SLEEP PHASE DISORDER; MELATONIN; RANDOMIZED CONTROLLED TRIAL; TREATMENT;

ADOLESCENT; ADULT; CIRCADIAN RHYTHM; COGNITION; DOUBLE-BLIND METHOD; FATIGUE; FEMALE; HUMANS; MALE; MELATONIN; NORWAY; PATIENT COMPLIANCE; PHOTOTHERAPY; PLACEBOS; SLEEP DISORDERS, CIRCADIAN RHYTHM; YOUNG ADULT;

EID: 84885810755     PISSN: 07487304     EISSN: 15524531     Source Type: Journal    
DOI: 10.1177/0748730413500126     Document Type: Article

References (50)

1. Akerstedt T, Gillberg M. Subjective and objective sleepiness in the active individual. Int J Neurosci. 1990 ; 52: 29-37
2. Alloway CE, Ogilvie RD, Shapiro CM. The Alpha Attenuation Test: assessing excessive daytime sleepiness in narcolepsy-cataplexy. Sleep. 1997 ; 20: 258-266
3. The International Classification of Sleep Disorders: Diagnostic and Coding Manual. Westchester (IL): American Academy of Sleep Medicine ; 2005 :
4. Bjorvatn B, Pallesen S. A practical approach to circadian rhythm sleep disorders. Sleep Med Rev. 2009 ; 13: 47-60
5. Carskadon MA, Dement WC, Mitler MM, Roth T, Westbrook PR, Keenan S. Guidelines for the Multiple Sleep Latency Test (MSLT): a standard measure of sleepiness. Sleep. 1986 ; 9: 519-524
6. Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, Wallace EP. Development of a fatigue scale. J Psychosom Res. 1993 ; 37: 147-153
7. Cole RJ, Smith JS, Alcala YC, Elliott JA, Kripke DF. Bright-light mask treatment of delayed sleep phase syndrome. J Biol Rhythms. 2002 ; 17: 89-101
8. Conners K, Staff MHS Conners' Continuous Performance Test (CPT II): Version 5 for Windows. Technical Guide and Software Manual. Toronto: Multi-Health Systems Inc ; 2004:
9. Crowley SJ, Acebo C, Carskadon MA. Sleep, circadian rhythms, and delayed phase in adolescence. Sleep Med. 2007 ; 8: 602-612
10. Dagan Y, Eisenstein M. Circadian rhythm sleep disorders: toward a more precise definition and diagnosis. Chronobiol Int. 1999 ; 16: 213-222
11. Dahlitz M, Alvarez B, Vignau J, English J, Arendt J, Parkes JD. Delayed sleep phase syndrome response to melatonin. Lancet. 1991 ; 337: 1121-1124
12. Delis DC, Kaplan E, Kramer JH Delis-Kaplan Executive Function System (D-KEFS). San Antonio (TX): Pearson ; 2001:
13. Dijk DJ, Duffy JF, Silva EJ, Shanahan TL, Boivin DB, Czeisler CA. Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS One. 2012 ; 7: e30037
14. Duffy JF, Wright KP. Entrainment of the human circadian system by light. J Biol Rhythms. 2005 ; 20: 326-338
15. First MB, Spitzer RL, Gibbon M, Williams JB User's Guide for the Structures Clinical Interview for DSM-IV Axis I Disorders: SCID-I. Clinical Version. Arlington (VA): American Psychiatric Publishing Inc ; 1997:
16. Gradisar M, Dohnt H, Gardner G, Paine S, Starkey K, Menne A, Slater A, Wright H, Hudson JL, Weaver E, Trenowden S. A randomized controlled trial of cognitive-behavior therapy plus bright light therapy for adolescent delayed sleep phase disorder. Sleep. 2011a ; 34: 1671-1680
17. Gradisar M, Gardner G, Dohnt H. Recent worldwide sleep patterns and problems during adolescence: a review and meta-analysis of age, region, and sleep. Sleep Med. 2011b ; 12: 110-118
18. Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomised controlled trials. BMJ. 1999 ; 319: 670-674
19. Horne JA. Sleepiness as a need for sleep: when is enough, enough?. Neurosci Biobehav Rev. 2010 ; 34: 108-118
20. Iber C, Ancoli-Israel S, Chesson A, Quan SF The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 2007 ) The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 1st ed. Westchester (IL): American Academy of Sleep Medicine. Westchester (IL): American Academy of Sleep Medicine ; 2007:
21. Johns MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep. 1991 ; 14: 540-545
22. Kayumov L, Brown G, Jindal R, Buttoo K, Shapiro CM. A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome. Psychosom Med. 2001 ; 63: 40-48
23. Khalsa SB, Jewett ME, Cajochen C, Czeisler CA. A phase response curve to single bright light pulses in human subjects. J Physiol. 2003 ; 549: 945-952
24. Lack LC, Bramwell T, Wright H, Kemp K. Morning blue light can advance the melatonin rhythm in mild delayed sleep phase syndrome. Sleep Biol Rhythms. 2007 ; 5: 78-80
25. Lewy AJ, Bauer VK, Asaeeduddin A, Thomas KH, Cutler NL, Singer CM, Moffit MT, Sack RL. The human response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light. Chronobiol Int. 1998 ; 15: 71-83
26. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science. 1980 ; 210: 1267-1269
27. Loge JH, Ekeberg O, Kaasa S. Fatigue in the general Norwegian population: normative data and associations. J Psychosom Res. 1998 ; 45: 53-65
28. Mundey K, Benloucif S, Harsanyi K, Dubocovich ML, Zee PC. Phase-dependent treatment of delayed sleep phase syndrome with melatonin. Sleep. 2005 ; 28: 1271-1278
29. Nagtegaal JE, Kerkhof GA, Smits MG, Swart AC, Van Der Meer YG. Delayed sleep phase syndrome: a placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. J Sleep Res. 1998 ; 7: 135-143
30. Pallesen S, Nordhus IH, Omvik S, Sivertsen B, Tell GS, Bjorvatn B. Prevalence and risk factors of subjective sleepiness in the general adult population. Sleep. 2007 ; 30: 619-624
31. Rahman SA, Kayumov L, Shapiro CM. Antidepressant action of melatonin in the treatment of delayed sleep phase syndrome. Sleep Med. 2010 ; 11: 131-136
32. Raven J. The Raven's progressive matrices: change and stability over culture and time. Cogn Psychol. 2000 ; 41: 1-48
33. Regestein QR, Monk TH. Delayed sleep phase syndrome: a review of its clinical aspects. Am J Psychiatry. 1995 ; 152: 602-608
34. Reid KJ, Jaksa AA, Eisengart JB, Baron KG, Lu B, Kane P, Kang J, Zee PC. Systematic evaluation of Axis-I DSM diagnoses in delayed sleep phase disorder and evening-type circadian preference. Sleep Med. 2012 ; 13: 1171-1177
35. Rosenthal NE, Joseph-Vanderpool JR, Levendosky AA, Johnston SH, Allen R, Kelly KA, Souetre E, Schultz PM, Starz KE. Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome. Sleep. 1990 ; 13: 354-361
36. Saxvig IW, Pallesen S, Wilhelmsen-Langeland A, Molde H, Bjorvatn B. Prevalence and correlates of delayed sleep phase in high school students. Sleep Med. 2012 ; 13: 193-199
37. SaxvigIWWilhelmsen-LangelandAPallesenSNordhusIHVedaaØBjorvatnB (2013a) A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: effects on subjective and objective sleep. Chronobiol Int. In press.
38. Saxvig IW, Wilhelmsen-Langeland A, Pallesen S, Nordhus IH, Vedaa Ø, Sørensen E, Bjorvatn B. Objective measures of sleep and dim light melatonin onset in adolescents and young adults with delayed sleep phase disorder compared to healthy controls. J Sleep Res. 2013b ; 22: 365-372
39. Sharkey KM, Carskadon MA, Figueiro MG, Zhu Y, Rea MS. Effects of an advanced sleep schedule and morning short wavelength light exposure on circadian phase in young adults with late sleep schedules. Sleep Med. 2011 ; 12: 685-692
40. Shekleton JA, Rogers NL, Rajaratnam SM. Searching for the daytime impairments of primary insomnia. Sleep Med Rev. 2010 ; 14: 47-60
41. Stampi C, Stone P, Michimori A. A new quantitative method for assessing sleepiness: the Alpha Attenuation Test. Work Stress. 1995 ; 9: 368-376
42. Switula D. Principles of Good Clinical Practice (GCP) in clinical research. Sci Eng Ethics. 2000 ; 6: 71-77
43. Thorpy MJ, Korman E, Spielman AJ, Glovinsky PB. Delayed sleep phase syndrome in adolescents. J Adolesc Health Care. 1988 ; 9: 22-27
44. Van Dongen HP, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep. 2003 ; 26: 117-126
45. Vetter C, Juda M, Roenneberg T. The influence of internal time, time awake, and sleep duration on cognitive performance in shiftworkers. Chronobiol Int. 2012 ; 29: 1127-1138
46. Wechsler D Wechsler Adult Intelligence Scale: Administration and Scoring Manual. 1997 ) Wechsler Adult Intelligence Scale: Administration and Scoring Manual. 3rd ed.San Antonio (TX): The Psychological Corporation. San Antonio (TX): The Psychological Corporation ; 1997:
47. Weitzman ED, Czeisler CA, Coleman RM, Spielman AJ, Zimmerman JC, Dement W, Richardson G, Pollak CP. Delayed sleep phase syndrome: a chronobiological disorder with sleep-onset insomnia. Arch Gen Psychiatry. 1981 ; 38: 737-746
48. Wilhelmsen-Langeland A, Dundas I, Saxvig IW, Pallesen S, Nordhus IH, Bjorvatn B. Psychosocial challenges related to delayed sleep phase disorder. Open Sleep J. 2012 ; 5: 51-58
49. Wright HR, Lack LC, Kennaway DJ. Differential effects of light wavelength in phase advancing the melatonin rhythm. J Pineal Res. 2004 ; 36: 140-144
50. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983 ; 67: 361-370