Carbapenem and cefoxitin resistance of klebsiella pneumoniae strains associated with porin ompK36 loss and DHA-1 β-lactamase production

Brazilian Journal of Microbiology

Volumn 44, Issue 2, 2013, Pages 435-442

  Shi, Weifeng ^a   Li, Kun ^a   Ji, Yun ^a   Jiang, Qinbo ^a   Wang, Yuyue ^a   Shi, Mei ^a   Mi, Zuhuang ^b  

^a THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b Wuxi Clone Gen Tech Institute   (China)

Author keywords

AmpC lactamase; Klebsiella pneumoniae; Molecular biology; Porin

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CEFOXITIN; OMPK36 PROTEIN, KLEBSIELLA PNEUMONIAE; PORIN;

ANTIBIOTIC RESISTANCE; CHEMISTRY; CHINA; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HOSPITAL; HUMAN; KLEBSIELLA INFECTION; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; SECRETION (PROCESS);

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; CEFOXITIN; CHINA; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HOSPITALS; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR WEIGHT; POLYMERASE CHAIN REACTION; PORINS;

EID: 84885783780     PISSN: 15178382     EISSN: 16784405     Source Type: Journal    
DOI: 10.1590/S1517-83822013000200015     Document Type: Article

References (25)

1. Coyne S, Rosenfeld N, Lambert T, Courvalin Pand Perichon B (2010) Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acine-tobacter baumannii. Antimicrob Agents Chemother. 54:4389-4393.
2. Ding H, Yang Y, Lu Q, Wang Y, Chen Y, Deng L, Wang A, Deng Q, Zhang Hand Wang C (2008) The prevalence of plas-mid-mediated AmpC P-lactamases among clinical isolates of Escherichia coli and Klebsiella pneumoniae from five children's hospitals in China. European journal of clinical microbiology & infectious diseases 27:915-921.
3. Doumith M, Ellington MJ, Livermore DMand Woodford N (2009) Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK. J Antimicrob Chemother 63:659-667.
4. Endimiani A, DePasquale JM, Forero S, Perez F, Hujer AM, Roberts-Pollack D, Fiorella PD, Pickens N, Kitchel Band Casia-no-Colón AE (2009) Emergence of blaKPC-containing Klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system. Journal of Antimicrobial Chemotherapy 64:1102.
5. Goldfarb D, Harvey SB, Jessamine K, Jessamine P, Toye Band Desjardins M (2009) Detection of plasmid-mediated KPC-producing Klebsiella pneumoniae in Ottawa, Canada: evidence of intrahospital transmission. J Clin Microbiol 47:1920-1922.
6. Guglierame P, Pasca MR, De Rossi E, Buroni S, Arrigo P, Manina Gand Riccardi G (2006) Efflux pump genes of the resis-tance-nodulation-division family in Burkholderia cenoce-pacia genome. BMC Microbiol. 6:66.
7. Hernandez-Alles S, Alberti S, Alvarez D, Domenech-Sanchez A, Martinez-Martinez L, Gil J, Tomas JMand Benedi VJ (1999) Porin expression in clinical isolates of Klebsiella pneumoniae. Microbiology 145:673-679.
8. Huang YT and Hsueh PR (2008) Antimicrobial drug resistance in Taiwan. Int J Antimicrob Agents.32 Suppl 3:174-178.
9. Husain Fand Nikaido H (2010) Substrate path in the AcrB multi-drug efflux pump of Escherichia coli. Mol Microbiol 78:320-330.
10. Jiang X, Espedido BA, Partridge SR, Thomas LC, Wang Fand Iredell JR (2009) Paradoxical effect of Klebsiella pneumo-niae OmpK36 porin deficiency. Pathology 41:388-392.
11. Jiang Y, Yu D, Wei Z, Shen P, Zhou Zand Yu Y (2010) Complete nucleotide sequence of Klebsiella pneumoniae multidrug resistance plasmid pKP048, carrying blaKPC-2, blaDHA-1, qnrB4, and armA. Antimicrob Agents Chemother 54:3967-3969.
12. Kaczmarek FM, Dib-Hajj F, Shang Wand Gootz TD (2006) High-level carbapenem resistance in a Klebsiella pneumo-niae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe. Antimicrob Agents Chemother 50:3396-3406.
13. Kontopoulou K, Protonotariou E, Vasilakos K, Kriti M, Koteli A, Antoniadou Eand Sofianou D (2010) Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 beta-lactamase resistant to colistin. J Hosp Infect 76:70-73.
14. Landman D, Bratu Sand Quale J (2009) Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae. J Med Microbiol 58:1303-1308.
15. Lee K, Yong D, Choi YS, Yum JH, Kim JM, Woodford N, Livermore DMand Chong Y (2007) Reduced imipenem susceptibility in Klebsiella pneumoniae clinical isolates with plasmid-mediated CMY-2 and DHA-1 beta-lactamases co-mediated by porin loss. Int J Antimicrob Agents 29:201-206.
16. Maltezou HC, Giakkoupi P, Maragos A, Bolikas M, Raftopoulos V, Papahatzaki H, Vrouhos G, Liakou Vand Vatopoulos AC (2009) Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece). J Infect 58:213-219.
17. Martinez-Martinez L (2008) Extended-spectrum beta-lactamases and the permeability barrier. Clin Microbiol Infect.14 Suppl 1:82-89.
18. Munoz-Price L, Sand Quinn JP (2009) The spread of Klebsiella pneumoniae carbapenemases: a tale of strains, plasmids, and transposons. Clin Infect Dis 49:1739-1741.
19. Piddock LJ (2006) Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Micro-biol Rev 19:382-402.
20. Pournaras S, Kristo I, Vrioni G, Ikonomidis A, Poulou A, Petro-poulou Dand Tsakris A (2010) Characteristics of merope-nem heteroresistance in Klebsiella pneumoniae carbape-nemase (KPC)-producing clinical isolates of K. pneumoniae. J Clin Microbiol 48:2601-2604.
21. Shi WF, Jiang JP, Xu N, Huang ZMand Wang YY (2005) Inhibitory effects of reserpine and carbonyl cyanide m-chloro-phenylhydrazone on fluoroquinolone resistance of Acineto-bacter baumannii. Chin Med J 118:340-343.
22. Su LH, Chu C, Cloeckaert Aand Chiu CH (2008) An epidemic of plasmids? Dissemination of extended spectrum cephalospo-rinases among Salmonella and other Enterobacteriaceae. FEMS Immunology & Medical Microbiology 52:155-168.
23. Wang XD, Cai JC, Zhou HW, Zhang Rand Chen GX (2009) Reduced susceptibility to carbapenems in Klebsiella pneu-moniae clinical isolates associated with plasmid-mediated beta-lactamase production and OmpK36 porin deficiency. J Med Microbiol 58:1196-1202.
24. Yamada Y, Ishii Y, Kouyama Y, Katho M, Odashiro R, Yamahata K, Tateda K, Yamaguchi Kand Suwabe A (2009) Characterization of Klebsiella pneumoniae producing SHV-12 and DHA-1 beta-lactamases accompanied by carbapenem resistance during hospitalization in a chronic care ward in Japan. J Chemother 21:445-447.
25. Zhang Y, Bao Q, Gagnon LA, Huletsky A, Oliver A, Jin Sand Langaee T (2010) ampG gene of Pseudomonas aeruginosa and its role in beta-lactamase expression. Antimicrob Agents Chemother 54:4772-4779.