Maternal adverse effects of different antenatal magnesium sulphate regimens for improving maternal and infant outcomes: A systematic review

BMC Pregnancy and Childbirth

Volumn 13, Issue , 2013, Pages

  Bain, Emily S ^a   Middleton, Philippa F ^a   Crowther, Caroline A ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Adverse effect; Antenatal; Magnesium sulfate; Magnesium sulphate; Systematic review

Indexed keywords

ANTIHYPERTENSIVE AGENT; GLUCONATE CALCIUM; MAGNESIUM SULFATE; NIFEDIPINE; PLACEBO;

AGITATION; APPENDICITIS; ARTICLE; BIBLIOGRAPHIC DATABASE; BLEEDING; BLURRED VISION; BRADYCARDIA; BREAST ENGORGEMENT; CARDIOPULMONARY ARREST; CENTRAL PONTINE MYELINOLYSIS; CESAREAN SECTION; CHEST TIGHTNESS; CHOLECYSTITIS; COMA; COMPARATIVE STUDY; CONFUSION; CYANOSIS; DELIRIUM; DIPLOPIA; DIZZINESS; DROWSINESS; DRUG DOSE COMPARISON; DRUG OVERDOSE; DRUG WITHDRAWAL; DYSPNEA; ECLAMPSIA; EDEMA; FATIGUE; FLUSHING; GALACTORRHEA; HEADACHE; HEART ARREST; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART PAIN; HEART PALPITATION; HEAT; HOARSENESS; HUMAN; HYPERKALEMIA; HYPOCALCEMIA; HYPONATREMIA; HYPOTENSION; HYPOTHERMIA; ILEUS; INJECTION SITE IRRITATION; INJECTION SITE PAIN; INJECTION SITE REACTION; KIDNEY FAILURE; LABIAL SWELLING; LUNG EDEMA; MALAISE; MATERNAL DISEASE; MATERNAL MORTALITY; MILK PRODUCTION; MUSCLE CONTRACTION; MUSCLE WEAKNESS; MYALGIA; MYOPATHY; NAUSEA; NAUSEA AND VOMITING; NEUROMUSCULAR JUNCTION DISORDER; NEUROPATHOLOGY; NEUROPROTECTION; OSTEOPENIA; OSTEOPOROSIS; OUTCOME ASSESSMENT; PAIN; PARALYSIS; PARESTHESIA; PHLEBITIS; PHOTOPHOBIA; POSTPARTUM HEMORRHAGE; PREECLAMPSIA; PREMATURE LABOR; PRURITUS; PUBLICATION; QT PROLONGATION; QUADRIPLEGIA; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; RESPIRATION DEPRESSION; RESPIRATORY ARREST; RESPIRATORY FAILURE; RISK; SIDE EFFECT; SLURRED SPEECH; SOMNOLENCE; SWEATING; SWELLING; SYSTEMATIC REVIEW; TACHYCARDIA; TENDON REFLEX; TETANY; THIRST; THORAX PAIN; TOCOLYSIS; UROLITHIASIS; URTICARIA; VISUAL ACUITY; VISUAL DISORDER; VOMITING; VULVAR EDEMA; WEAKNESS; XEROSTOMIA;

ADMINISTRATION, INTRAVENOUS; ANTICONVULSANTS; ECLAMPSIA; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; MAGNESIUM SULFATE; PREGNANCY; PREMATURE BIRTH; WITHHOLDING TREATMENT;

EID: 84885778833     PISSN: None     EISSN: 14712393     Source Type: Journal    
DOI: 10.1186/1471-2393-13-195     Document Type: Article

References (167)

1. Duley L, Gülmezoglu A, Chou D. Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database Syst Rev 2010, 9. CD002960.
2. Duley L, Henderson-Smart D, Chou D. Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev 2010, 10. CD000128.
3. Duley L, Henderson-Smart D, Walker G, Chou D. Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev 2010, 12. CD000127.
4. Duley L, Gulmezoglu A, Henderson-Smart D, Chou D. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev 2010, 11. CD000025.
5. Crowther CA, Hiller JE, Doyle LW. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev 2002, 4. CD001060.
6. Han S, Crowther CA, Moore V. Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour. Cochrane Database Syst Rev 2010, 7. CD000940.
7. Doyle LW, Crowther CA, Middleton P, Marret S, Rouse DJ. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2009, 1. CD004661.
8. Lu J, Nightingale C. Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles. Clin Pharmacokinet 2000, 38(4):305-314. 10.2165/00003088-200038040-00002, 10803454.
9. Duley L, Matar H, Almerie M, Hall D. Alternative magnesium sulphate regimens for women with pre-eclampsia and eclampsia. Cochrane Database Syst Rev 2010, 8. CD007388.
10. Golder S, Loke YK, Bland M. Meta-analyses of adverse effects data derived from randomised controlled trials as compared to observational studies: methodological overview. PLoS Med 2011, 8(5):e1001026. 10.1371/journal.pmed.1001026, 3086872, 21559325.
11. Papanikolaou PN, Christidi GD, Ioannidis JPA. Comparison of evidence on harms of medical interventions in randomized and nonrandomized studies. CMAJ 2006, 174(5):635-641. 10.1503/cmaj.050873, 1389826, 16505459.
12. Loke Y, Price D, Herxheimer A. Cochrane Adverse Effects Methods Group Systematic reviews of adverse effects: framework for a structured approach. BMC Med Res Methodol 2007, 7:1-9. 10.1186/1471-2288-7-1, 1783663, 17217545, Cochrane Adverse Effects Methods Group.
13. Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 2011, The Cochrane Collaboration, Available at: http://handbook.cochrane.org.
14. Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell M. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.
15. Ioannidis JPA, Evans SJW, Gotzsche PC, O'Neill RT, Altman DG, Schulz K, Moher D. CONSORT Group Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann Intern Med 2004, 141(1):781-788. CONSORT Group.
16. Chen FP, Chang SD, Chu KK. Expectant management in severe preeclampsia: does magnesium sulfate prevent the development of eclampsia?. Acta Obstet Gynecol Scand 1995, 74:181-185. 10.3109/00016349509008935, 7900522.
17. Coetzee EJ, Dommisse J, Anthony J. A randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia. Br J Obstet Gynaecol 1998, 105(3):300-303. 10.1111/j.1471-0528.1998.tb10090.x, 9532990.
18. Cox SM, Sherman ML, Leveno KJ. Randomized investigation of magnesium sulfate for prevention of preterm birth. Am J Obstet Gynecol 1990, 163(3):767-772. 10.1016/0002-9378(90)91065-K, 2206069.
19. Crowther CA, Hiller JE, Doyle LW, Haslam RR. Australasian Collaborative Trial of Magnesium Sulphate Collaborative Group Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. JAMA 2006, 290(2):2669-2676. Australasian Collaborative Trial of Magnesium Sulphate Collaborative Group.
20. The Magpie Trial Collaborative Group Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: A randomised placebo-controlled trial. Lancet 2002, 359(9321):1877-1890. The Magpie Trial Collaborative Group.
21. Livingston JC, Livingston LW, Ramsey R, Mabie BC, Sibai BM. Magnesium sulfate in women with mild preeclampsia: a randomized controlled trial. Obstet Gynecol 2003, 101(2):217-220. 10.1016/S0029-7844(02)03053-3, 12576241.
22. Ma L. Magnesium sulfate in prevention of preterm labor. Zhong hua yi xue za zhi 1992, 72(3):158-161.
23. Marret S, Marpeau L, Zupan-Simunek V, Eurin D, Leveque C, Hellot M-F, Benichou J. PREMAG trial group Magnesium sulfate given before very-preterm birth to protect infant brain: the randomized controlled PREMAG trial. Br J Obstet Gynaecol 2007, 114(3):310-318. PREMAG trial group.
24. Moodley J, Moodley VV. Prophylactic anticonvulsant therapy in hypertensive crises of pregnancy the need for a large, randomized trial. Hypertens Pregnancy 1994, 13(3):245-252.
25. Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Alexander JM, Harper M, Thorp JM, Ramin SM, Malone FD, Carpenter M, Miodovnik M, Moawad A, O'Sullivan MJ, Peaceman AM, Hankins GDV, Langer O, Caritis SN, Roberts JM. For the Eunice Kennedy Shiver NICHD Maternal-Fetal Medicine Units Network A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med 2008, 359:895-905. 10.1056/NEJMoa0801187, 2803083, 18753646, For the Eunice Kennedy Shiver NICHD Maternal-Fetal Medicine Units Network.
26. Witlin AG, Friedman SA, Sibai BM. The effect of magnesium sulfate therapy on the duration of labor in women with mild preeclampsia at term: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol 1997, 176(3):623-627. 10.1016/S0002-9378(97)70558-1, 9077617.
27. Shilva Saha SC, Kalra J, Prasad R. Safety and efficacy of low-dose MgSO4 in the treatment of eclampsia. Int J Gynaecol Obstet 2007, 97(2):150-151. 10.1016/j.ijgo.2007.01.008, 17368649.
28. Malapaka SVN, Ballal PK. Low-dose magnesium sulfate versus Pritchard regimen for the treatment of eclampsia imminent eclampsia. Int J Gynaecol Obstet 2011, 115(1):70-72. 10.1016/j.ijgo.2011.05.013, 21798536.
29. Bhattacharjee N, Saha SP, Ganguly RP, Patra KK, Dhali B, Das N, Barui G. A randomised comparative study between low-dose intravenous magnesium sulphate and standard intramuscular regimen for treatment of eclampsia. J Obstet Gynaecol 2011, 31(4):298-303. 10.3109/01443615.2010.549972, 21534749.
30. Chissell S, Botha JH, Moodley J, McFadyen L. Intravenous and intramuscular magnesium sulphate regimens in severe pre-eclampsia. S Afr Med J 1994, 84(9):607-610.
31. Mundle S, Regi A, Biswas B, Bracken H, Easterling T, Winikoff B. Preeclampsia in low-resource settings: a randomized trial of IV MgSO4 via flow controlled pump. Int J Gynaecol Obstet 2009, 107(2):S278.
32. Ehrenberg HM, Mercer BM. Abbreviated postpartum magnesium sulfate therapy for women with mild preeclampsia: a randomized controlled trial. Obstet Gynecol 2006, 108(4):833-838. 10.1097/01.AOG.0000236493.35347.d8, 17012443.
33. Suneja A, Sinha S, Vaid N, Ahuja S. A prospective randomized controlled trial to individualize the duration of post partum magnesium sulfate therapy. Hypertens Pregnancy 2008, 27:504.
34. Behrad V, Moossavifar N, Mojtahedzadeh M, Esmaili H, Moghtadeii P. A prospective, randomized, controlled trial of high and low doses of magnesium sulfate for acute tocolysis. Acta Med Iran 2003, 41(2):126-131.
35. Terrone DA, Rinehart BK, Kimmel ES, May WL, Larmon JE, Morrison JC. A prospective, randomized, controlled trial of high and low maintenance doses of magnesium sulfate for acute tocolysis. Am J Obstet Gynecol 2000, 182(6):1477-1482. 10.1067/mob.2000.107334, 10871468.
36. Zygmunt M, Heilmann L, Berg C, Wallwiener D, Grischke E, Munstedt K, Spindler A, Lang U. Local and systemic tolerability of magnesium sulphate for tocolysis. Eur J Obstet Gynecol Reprod Biol 2003, 107(2):168-175. 10.1016/S0301-2115(02)00368-8, 12648863.
37. Ales KL, Charlson ME. Prognosis of hypertension first documented during labor. Am J Perinatol 1987, 4(4):317-323. 10.1055/s-2007-999799, 3651190.
38. Seyb ST, Berka RJ, Socol ML, Dooley SL. Risk of cesarean delivery with elective induction of labor at term in nulliparous women. Obstet Gynecol 1999, 94(4):600-607. 10.1016/S0029-7844(99)00377-4, 10511367.
39. Park KH, Cho YK, Lee CM, Choi H, Kim BR, Lee HK. Effect of preeclampsia, magnesium sulfate prophylaxis, and maternal weight on labor induction: a retrospective analysis. Gynecol Obstet Invest 2006, 61(1):40-44. 10.1159/000088424, 16179789.
40. Assaley J, Baron JM, Cibils LA. Effects of magnesium sulfate infusion upon clotting parameters in patients with pre-eclampsia. J Perinat Med 1998, 26(2):115-119. 10.1515/jpme.1998.26.2.115, 9650132.
41. Kynczl-Leisure M, Cibils LA. Increased bleeding time after magnesium sulfate infusion. Am J Obstet Gynecol 1996, 175(5):1293-1294. 10.1016/S0002-9378(96)70043-1, 8942503.
42. Ramanathan J, Sibai BM, Duggirala V, Maduska AL. Pulmonary function in preeclamptic women receiving MgSO4. J Reprod Med 1988, 33(5):432-435.
43. Ramanathan J, Sibai BM, Pillai R, Angel JJ. Neuromuscular transmission studies in preeclamptic women receiving magnesium sulfate. Am J Obstet Gynecol 1988, 158(1):40-46. 10.1016/0002-9378(88)90772-7, 2827486.
44. Poggi SH, Barr S, Cannum R, Collea JV, Landy HJ, Kezsler M, Ghidini A. Risk factors for pulmonary edema in triplet pregnancies. J Perinatol 2003, 23(6):462-465. 10.1038/sj.jp.7210968, 13679932.
45. Magee LA, Miremadi S, Li J, Cheng C, Ensom MHH, Carleton B, Cote A-M, Von-Dadelszan P. Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia. Am J Obstet Gynecol 2005, 193(1):153-163. 10.1016/j.ajog.2004.11.059, 16021073.
46. Chowdhury JR, Chaudhuri S, Bhattacharyya N, Biswas PK, Panpalia M. Comparison of intramuscular magnesium sulfate with low dose intravenous magnesium sulfate regimen for treatment of eclampsia. J Obstet Gynaecol Res 2009, 35(1):119-125. 10.1111/j.1447-0756.2008.00842.x, 19215558.
47. Mahajan NN, Thomas A, Soni RN, Gaikwad NL, Jain SM. 'Padhar regime' - a low-dose magnesium sulphate treatment for eclampsia. Gynecol Obstet Invest 2009, 67(1):20-24. 10.1159/000158647, 18824861.
48. Young BK, Weinstein HM. Effects of magnesium sulfate on toxemic patients in labor. Obstet Gynecol 1977, 49(6):681-685.
49. Shoaib T, Khan S, Javed I, Bhutta SZ. Loading dose of magnesium sulphate versus standard regime for prophylaxis of pre-eclampsia. J Coll Physicians Surg Pak 2009, 19(1):30-33.
50. Palmer L, Newby BD. Development of a simplified protocol for administration of 20% magnesium sulphate for prophylaxis and treatment of eclampsia. Can J Hosp Pharm 2009, 62(6):490-495. 2827019, 22478937.
51. Nassar AH, Sakhel K, Maarouf H, Naassan GR, Usta IM. Adverse maternal and neonatal outcome of prolonged course of magnesium sulfate tocolysis. Acta Obstet Gynecol Scand 2006, 85(9):1099-1103. 10.1080/00016340600756896, 16929415.
52. Aali BS, Khazaeli P, Ghasemi F. Ionized and total magnesium concentration in patients with severe preeclampsia-eclampsia undergoing magnesium sulfate therapy. J Obstet Gynaecol Res 2007, 33(2):138-143. 10.1111/j.1447-0756.2007.00508.x, 17441885.
53. Adewole IF, Oladokun A, Okewole AI, Omigbodun AO, Afolabi A, Ekele B, Audu LR, Obed Y. Magnesium sulphate for treatment of eclampsia: the Nigerian experience. Afr J Med Med Sci 2000, 29(3-4):239-241.
54. Ekele BA, Badung SLH. Is serum magnesium estimate necessary in patients with eclampsia on magnesium sulphate?. Afr J Reprod Health 2005, 9(1):128-132.
55. Pritchard JA, Cunningham FG, Pritchard SA. The Parkland Memorial Hospital protocol for treatment of eclampsia: evaluation of 245 cases. Am J Obstet Gynecol 1984, 148(7):951-963. 10.1016/0002-9378(84)90538-6, 6711634.
56. Raman NV, Rao CA. Magnesium sulfate as an anticonvulsant in eclampsia. Int J Gynaecol Obstet 1995, 49(3):289-298. 10.1016/0020-7292(95)02388-S, 9764868.
57. Elliott JP. Magnesium sulfate as a tocolytic agent. Am J Obstet Gynecol 1983, 147(3):277-284.
58. Girard B, Beucher G, Muris C, Simonet T, Dreyfus M. Magnesium sulphate and severe preeclampsia: its use in current practice. J Gynecol Obstet Biol Reprod 2005, 34(1 Pt 1):17-22.
59. Harding K, Erskine K, Howell P. Audit of the impact of magnesium sulphate on the management of severe pre-eclampsia in a London university hospital. Eur J Anaesthesiol 1997, 14(5):527-528.
60. Thapa K, Jha R. Magnesium sulphate: a life saving drug. J Nepal Med Assoc 2008, 47(171):104-108.
61. Dasari P, Habeebullah S. Maternal mortality due to hypertensive disorders of pregnancy in a tertiary care center in Southern India. Int J Gynaecol Obstet 2010, 110(3):271-273. 10.1016/j.ijgo.2010.04.021, 20570262.
62. Donovan EF, Tsang RC, Steichen JJ, Strub RJ, Chen IW, Chen M. Neonatal hypermagnesemia: effect on parathyroid hormone and calcium homeostasis. J Pediatr 1980, 96(2):305-310. 10.1016/S0022-3476(80)80835-3, 7351603.
63. Mojadidi Q, Thompson RJ. Five years' experience with eclampsia. South Med 1973, 66(4):414-416.
64. Tukur J, Muhammad Z. Management of eclampsia at AKTH: before and after magnesium sulphate. Niger J Med 2010, 19(1):104-107.
65. Getaneh W, Kumbi S. Use of magnesium sulfate in pre-eclampsia and eclampsia in teaching hospitals in Addis Ababa: a practice audit. Ethiop Med J 2010, 48(2):157-164.
66. Ahmed R. Magnesium sulphate as an anticonvulsant in the management of eclampsia. J Coll Physicians Surg Pak 2004, 14(10):605-607.
67. Begum R, Begum A, Johanson R, Ali MN, Akhter S. A low dose ("Dhaka") magnesium sulphate regime for eclampsia. Acta Obstet Gynecol Scand 2001, 80(11):998-1002.
68. Digre KB, Varner MW, Schiffman JS. Neuroophthalmologic effects of intravenous magnesium sulfate. Am J Obstet Gynecol 1990, 163(6 Pt 1):1848-1852.
69. Hales KA, Matthews JP, Rayburn WF, Atkinson BD. Intravenous magnesium sulfate for premature labor: comparison between twin and singleton gestations. Am J Perinatol 1995, 12(1):7-10. 10.1055/s-2007-994388, 7710584.
70. Sass N, Mesquita M, Kenji G, Goncalves F, Arauj F. Do women with preeclampsia benefit from an exclusively intravenous magnesium sulphate regimen? Is 2.0 grams/hour effective? (abstract). Hypertens Pregnancy 2007, 4:S591.
71. Omu AE, Al-Harmi J, Vedi HL, Mlechkova L, Sayed AF, Al-Ragum NS. Magnesium sulphate therapy in women with pre-eclampsia and eclampsia in Kuwait. Med Princ Pract 2008, 17(3):227-232. 10.1159/000117797, 18408392.
72. Cotton DB, Gonik B, Dorman KF. Cardiovascular alterations in severe pregnancy-induced hypertension: acute effects of intravenous magnesium sulfate. Am J Obstet Gynecol 1984, 148(2):162-165. 10.1016/S0002-9378(84)80169-6, 6691393.
73. Yeast JD, Halberstadt C, Meyer BA, Cohen GR, Thorp JA. The risk of pulmonary edema and colloid osmotic pressure changes during magnesium sulfate infusion. Am J Obstet Gynecol 1993, 169(6):1566-1571. 10.1016/0002-9378(93)90438-O, 8267063.
74. Jirapinyo M, Thuvasethakul P, Leelaphiwat S. Prospective study on premature labor with magnesium sulfate. Asia Oceania J Obstet Gynaecol 1990, 16(2):91-96.
75. Kfuri TA, Morlock L, Hicks RW, Shore AD. Medication errors in obstetrics. Clin Perinatol 2008, 35(1):101-117. 10.1016/j.clp.2007.11.015, 18280878.
76. Little JA, Velazquez MB, Rayburn WF. Reported medication errors in obstetric inpatients in 1 hospital. J Reprod Med 2003, 48(10):818-820.
77. Bilgin T, Cengiz C, Ozan H. Alterations in respiratory functions during magnesium sulfate infusion in severe preeclampsia and eclampsia. Int J Gynaecol Obstet 1994, 45(1):59-60. 10.1016/0020-7292(94)90768-4, 7913062.
78. Herpolsheimer A, Brady K, Yancey MK, Pandian M, Duff P. Pulmonary function of preeclamptic women receiving intravenous magnesium sulfate seizure prophylaxis. Obstet Gynecol 1991, 78(2):241-244.
79. Ghia N, Spong CY, Starbuck VN, Scialli AR, Ghidini A. Magnesium sulfate therapy affects attention and working memory in patients undergoing preterm labor. Am J Obstet Gynecol 2000, 183(4):940-944. 10.1067/mob.2000.109045, 11035343.
80. Fuentes A, Rojas A, Porter KB, Saviello G, O'Brien WF. The effect of magnesium sulfate on bleeding time in pregnancy. Am J Obstet Gynecol 1995, 173(4):1246-1249. 10.1016/0002-9378(95)91363-7, 7485330.
81. Guzin K, Goynumer G, Gokdagli F, Turkgeldi E, Gunduz G, Kayabasoglu F. The effect of magnesium sulfate treatment on blood biochemistry and bleeding time in patients with severe preeclampsia. J Matern Fetal Neonatal Med 2010, 23(5):399-402. 10.3109/14767050903156684, 19639519.
82. Yazdani M, Jahvani FA, Tabei SZ. Effects of magnesium sulfate on bleeding time in premature labor. Iran J Med Sci 2004, 29(4):172-174.
83. Moghadas FRS, Motevalian M, Rezai Z, Ehteshamipour E. The effect of magnesium sulfate therapy on bleeding time in women with threatened preterm labor. Iran J Pharmacol Ther 2007, 6(1):55-57.
84. Anon Magnesium overdose kills pregnant R.Ph.; her twins saved. Drug Top 1990, 134:11-12. Anon.
85. Cohen MR, Davis NM. Free flow associated with electronic infusion devices: underestimated danger. Hosp Pharm 1992, 27(5):384-390.
86. Richards A, Stather-Dunn L, Moodley J. Cardiopulmonary arrest after the administration of magnesium sulphate. A case report. S Afr Med J 1985, 67(4):145.
87. Simpson KR, Knox GE. Obstetrical accidents involving intravenous magnesium sulfate: recommendations to promote patient safety. MCN Am J Matern Child Nurs 2004, 29(3):161-169. 10.1097/00005721-200405000-00006, 15123972.
88. McCubbin JM, Sibai BM, Ardella TN, Anderson GD. Cardiopulmonary arrest due to acute maternal hypermagnesaemia. Lancet 1981, 1(8228):1058.
89. McDonnell NJ. Cardiopulmonary arrest in pregnancy: two case reports of successful outcomes in association with perimortem Caesarean delivery. Br J Anaesth 2009, 103(3):406-409. 10.1093/bja/aep176, 19561013.
90. Morisaki H, Yamamoto S, Morita Y, Kotake Y, Ochiai R, Takeda J. Hypermagnesemia-induced cardiopulmonary arrest before induction of anesthesia for emergency cesarean section. J Clin Anesth 2000, 12(3):224-226. 10.1016/S0952-8180(00)00142-2, 10869923.
91. Rabinerson D, Gruber A, Kaplan B, Royburt M, Ovadia J. Accidental cardiopulmonary arrest following magnesium sulphate overdose. Eur J Obstet Gynecol Reprod Biol 1994, 55(2):149-150. 10.1016/0028-2243(94)90071-X, 7958154.
92. Swartjes JM, Schutte MF, Bleker OP. Management of eclampsia: cardiopulmonary arrest resulting from magnesium sulfate overdose. Eur J Obstet Gynecol Reprod Biol 1992, 47(1):73-75. 10.1016/0028-2243(92)90217-M, 1426514.
93. Bohman VR, Cotton DB. Supralethal magnesemia with patient survival. Obstet Gynecol 1990, 76(5 Pt 2):984-986.
94. Cao Z, Bideau R, Valdes R, Elin RJ. Acute hypermagnesemia and respiratory arrest following infusion of MgSO4 for tocolysis. Clin Chim Acta 1999, 285(1-2):191-193.
95. McKenna D. That's our drip counter!. Lancet 1873, 2006:367(9525).
96. Wax JR, Segna RA, Vandersloot JA. Magnesium toxicity and resuscitation-an unusual cause of postcesarean evisceration. Int J Gynaecol Obstet 1995, 48(2):213-214. 10.1016/0020-7292(94)02251-S, 7789597.
97. Bruhwiler H, Hafliger M, Luscher KP. Severe accidental magnesium poisoning in a twins pregnancy in the 32nd week of pregnancy. Geburtshilfe Frauenheilkd 1994, 54(3):184-186. 10.1055/s-2007-1023579, 8188021.
98. Hayashi K, Oshiro M, Takara I, Iha H, Sugahara K. Coma caused by hypermagnesemia in a pregnant woman complicated with HELLP syndrome. Masui 2003, 52(7):783-785.
99. McDonnell NJ, Muchatuta NA, Paech MJ. Acute magnesium toxicity in an obstetric patient undergoing general anaesthesia for caesarean delivery. Int J Obstet Anesth 2010, 19(2):226-231. 10.1016/j.ijoa.2009.09.009, 20219345.
100. Buettner AU. Two cases of inadvertent magnesium sulphate overdose. Int J Obstet Anesth 2011, 20(1):92-93. 10.1016/j.ijoa.2010.08.003, 21134738.
101. Dror A, Henriksen E. Accidental epidural magnesium sulfate injection. Anesth Analg 1987, 66(10):1020-1021.
102. Goodman EJ, Haas AJ, Kantor GS. Inadvertent administration of magnesium sulfate through the epidural catheter: report and analysis of a drug error. Int J Obstet Anesth 2006, 15(1):63-67. 10.1016/j.ijoa.2005.06.009, 16256336.
103. Lejuste MJ. Inadvertant intrathecal administration of magnesium sulfate. S Afr Med J 1985, 68(6):367-368.
104. Lewis-Younger C, Speranza V, Gaar G. Temporary paralysis resulting from medical error. J Toxicol Clin Toxicol 2004, 42(5):732.
105. Bashuk RG, Krendel DA. Myasthenia gravis presenting as weakness after magnesium administration. Muscle Nerve 1990, 13(8):708-712. 10.1002/mus.880130808, 2385256.
106. Bruner JP, Yeast JD. Pregnancy associated with Friedreich ataxia. Obstet Gynecol 1990, 76(5 Pt 2):976-977.
107. Catanzarite V, Gambling D, Bird LM, Honold J, Perkins E. Respiratory compromise after MgSO4 therapy for preterm labor in a woman with myotonic dystrophy: a case report. J Reprod Med 2008, 53(3):220-222.
108. Hosono T, Suzuki M, Chiba Y. Contraindication of magnesium sulfate in a pregnancy complicated with late-onset diabetes mellitus and sensory deafness due to mitochondrial myopathy. J Matern Fetal Med 2001, 10:355-356. 10.1080/jmf.10.5.355.356-20, 11730501.
109. Cohen BA, London RS, Goldstein PJ. Myasthenia gravis and preeclampsia. Obstet Gynecol 1976, 48(1 Suppl):35S-37S.
110. Mueksch JN, Stevens WA. Undiagnosed myasthenia gravis masquerading as eclampsia. Int J Obstet Anesth 2007, 16(4):379-382. 10.1016/j.ijoa.2007.03.012, 17693079.
111. Robins K, Lyons G. Opioid-related narcosis in a woman with myopathy receiving magnesium. Int J Obstet Anesth 2007, 16(4):367-369. 10.1016/j.ijoa.2007.01.013, 17643282.
112. Moriarty KT, McFarland R, Whittaker R, Burch J, Turnbull HE, Taylor RW, Turnbull DM. Pre-eclampsia and magnesium toxicity with therapeutic plasma level in a woman with m.3243A > G melas mutation. J Obstet Gynaecol 2008, 28(3):349. 10.1080/01443610802048545, 18569490.
113. Archer TL, Heitmeyer JD. Perioperative hemodynamics obtained by pulse contour analysis facilitated the management of a patient with chronic hypertension, renal insufficiency, and superimposed preeclampsia during cesarean delivery. J Clin Anesth 2010, 22(4):274-279. 10.1016/j.jclinane.2009.03.019, 20522358.
114. Chan SM, Lu CC, Ho ST, Liaw WJ, Cherng CH, Chen WH, Lin TC. Eclampsia following cesarean section with HELLP syndrome and multiple organ failure. Acta Anaesthesiol Taiwan 2008, 46(1):46-48. 10.1016/S1875-4597(08)60021-1, 18390402.
115. Nethravathi M, Panicker JN, Taly AB, Arunodaya GR, Sinha S. Therapeutic magnesium for eclampsia: an unusual cause for antepartum flaccid paralysis. J Postgrad Med 2007, 53(1):79-80. 10.4103/0022-3859.30341, 17244984.
116. Saitoh K, Motegi R, Hirabayashi Y, Shimizu R. Cardiac arrests probably induced by hypermagnesemia during anesthesia for caesarean section. Masui 1994, 43(3):388-391.
117. Baraka A, Dajani A, Jabagi S. Magnesium-induced respiratory arrest in a parturient recovering from general anesthesia-a case report. Middle East J Anesthesiol 1984, 7(6):437-440.
118. Nguyen TTT, Koenders MEF, Wierda JMKH. Drug interaction in a pregnancy complicated by pre-eclampsia and cesarean section. Ned Tijdschr Anesthesiol 2001, 14(1):21-25.
119. Fay TN, Bogod D. Magnesium sulphate: the time for reckoning. Br J Obstet Gynaecol 1996, 103(8):852.
120. Funai Y, Ikeda Y, Takahashi R, Asada A. Prolonged apnea from rocuronium in a patient with hypermagnesemia after cesarean section: a case report. Masui 2010, 59(6):721-723.
121. Hino H, Kaneko I, Miyazawa A, Aoki T, Ishizuka B, Kosuqi K, Amemiya A. Prolonged neuromuscular blockade with vecuronium in patient with triple pregnancy treated with magnesium sulfate. Masui 1997, 46(2):266-270.
122. Kwan WF, Lee C, Chen BJ. A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient. J Clin Anesth 1996, 8(5):392-397. 10.1016/0952-8180(96)00087-6, 8832451.
123. Sinatra RS, Philip BK, Naulty JS, Ostheimer GW. Prolonged neuromuscular blockade with vecuronium in a patient treated with magnesium sulfate. Anesth Analg 1985, 64(12):1220-1222.
124. Yoshida A, Itoh Y, Nagaya K, Takino K, Sugawara J-I, Murakami T, Okamura K, Takahashi M. Prolonged relaxant effects of vecuronium in patients with deliberate hypermagnesemia: time for caution in cesarean section. J Anesth 2006, 20(1):33-35. 10.1007/s00540-005-0354-9, 16421674.
125. Sloan PA, Rasul M. Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium. Anesth Analg 2002, 94(1):123-124.
126. Ben-Ami M, Giladi Y, Shalev E. The combination of magnesium sulphate and nifedipine: a cause of neuromuscular blockade. Br J Obstet Gynaecol 1994, 101(3):262-263. 10.1111/j.1471-0528.1994.tb13126.x, 8193107.
127. Snyder SW, Cardwell MS. Neuromuscular blockade with magnesium sulfate and nifedipine. Am J Obstet Gynecol 1989, 161(1):35-36. 10.1016/0002-9378(89)90226-3, 2750819.
128. Wu Q-A, Ye Y-Q. Neuromuscular blockade after therapy with magnesium sulfate and amlodipine. Eur J Obstet Gynecol Reprod Biol 2010, 149(2):225.
129. Pittman JA. Magnesium sulphate for pre-eclampsia and a sudden bradycardia. Br J Anaesth 2000, 85(2):327-328.
130. Scardo JA, Brost BC, Sola E, Newman RB, Tate SB. Severe hypotension with nifedipine-magnesium in severe preeclampsia: A hemodynamic observation. J Matern Fetal Investig 1997, 7(3):152-154.
131. Waisman GD, Mayorga LM, Camera MI, Vignolo CA, Martinotti A. Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia?. Am J Obstet Gynecol 1988, 159(2):308-309. 10.1016/S0002-9378(88)80072-3, 3407684.
132. Awwad JT, Khalil AM, Aswad NK, Suidan FJ, Karam KS. Labial edema in pregnancy. A case report. J Reprod Med 1994, 39(11):921-922.
133. Basaran A, Bozdag G, Aksu AT, Deren O. Twin pregnancy complicated with acute appendicitis and cholecystitis in the same gestational period. Arch Gynecol Obstet 2007, 276(3):291-293. 10.1007/s00404-007-0331-7, 17287980.
134. Haldeman W. Can magnesium sulfate therapy impact lactogenesis?. J Hum Lact 1993, 9(4):249-252. 10.1177/089033449300900426, 8260059.
135. Hill WC, Gill PJ, Katz M. Maternal paralytic ileus as a complication of magnesium sulfate tocolysis. Am J Perinatol 1985, 2(1):47-48. 10.1055/s-2007-999911, 3838678.
136. Hung J-W, Tsai M-Y, Yang B-Y, Chen J-F. Maternal osteoporosis after prolonged magnesium sulfate tocolysis therapy: a case report. Arch Phys Med Rehabil 2005, 86(1):146-149. 10.1016/j.apmr.2004.02.016, 15641005.
137. Lurie S, Rotmensch S, Feldman N, Glezerman M. Breast engorgement and galactorrhea during magnesium sulfate treatment of preterm labor. Am J Perinatol 2002, 19(5):239-240. 10.1055/s-2002-33086, 12152141.
138. Riggs JE, Hogg JP. Central pontine myelinolysis: association with parenteral magnesium administration. Mil Med 2000, 165(6):494-495.
139. Sameshima H, Higo T, Kodama Y, Ikenoue T. Magnesium tocolysis as the cause of urinary calculus during pregnancy. J Matern Fetal Med 1997, 6(5):296-297.
140. Spital A, Greenwell R. Severe hyperkalemia during magnesium sulfate therapy in two pregnant drug abusers. South Med J 1991, 84(7):919-921. 10.1097/00007611-199107000-00026, 2068641.
141. Roberts D, Haslett E, Hickey-Dwyer M, McCormack J. Eclampsia complicated by bilateral retinal detachments and abnormal eye movements. Lancet 1998, 351(9105):803-804. 10.1016/S0140-6736(05)78930-3, 9519957.
142. Thorp JM, Katz VL, Campbell D, Cefalo RC. Hypersensitivity to magnesium sulfate. Am J Obstet Gynecol 1989, 161(4):889-890. 10.1016/0002-9378(89)90744-8, 2801834.
143. Bourgeois FJ, Thiagarajah S, Harbert GM, DiFazio C. Profound hypotension complicating magnesium therapy. Am J Obstet Gynecol 1986, 154(4):919-920. 10.1016/0002-9378(86)90485-0, 3963084.
144. Rodis JF, Vintzileos AM, Campbell WA, Deaton JL, Nochimson DJ. Maternal hypothermia: an unusual complication of magnesium sulfate therapy. Am J Obstet Gynecol 1987, 156(2):435-436. 10.1016/0002-9378(87)90300-0, 3826181.
145. Cardosi RJ, Chez RA. Magnesium sulfate, maternal hypothermia, and fetal bradycardia with loss of heart rate variability. Obstet Gynecol 1998, 92(4 Pt 2):691-693.
146. Hennessy A, Hill I. A case of maternal bradycardia at therapeutic doses of magnesium sulphate in preeclampsia. Aust N Z J Obstet Gynaecol 1999, 39(2):256-257. 10.1111/j.1479-828X.1999.tb03387.x, 10755794.
147. Oettinger M, Perlitz Y. Asymptomatic paroxysmal atrial fibrillation during intravenous magnesium sulfate treatment in preeclampsia. Gynecol Obstet Invest 1993, 36(4):244-246. 10.1159/000292638, 8300011.
148. Pritchard JA. The use of magnesium sulfate in preeclampsia-eclampsia. J Reprod Med 1979, 23(3):107-114.
149. Herschel M, Mittendorf R. Tocolytic magnesium sulfate toxicity and unexpected neonatal death. J Perinatol 2001, 21(4):261-262. 10.1038/sj.jp.7200498, 11533846.
150. Tang F, Xiao B, Xiong Q, Yang M. A case report: magnesium intoxication occurring in the process of total serum magnesium decrease. J Obstet Gynaecol Res 2010, 36(1):174-177. 10.1111/j.1447-0756.2009.01084.x, 20178546.
151. Sherer D, Cialone P, Abramowicz J, Woods J. Transient symptomatic subendocardial ischemia suring magnesium sulfate tocolytic therapy. Am J Obstet Gynecol 1992, 166(1 Pt 1):33-35.
152. Koontz SL, Friedman SA, Schwartz ML. Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipine. Am J Obstet Gynecol 2004, 190(6):1773-1776. 10.1016/j.ajog.2004.02.050, 15284796.
153. Mayan H, Hourvitz A, Schiff E, Farfel Z. Symptomatic hypocalcaemia in hypermagnesaemia-induced hypoparathyroidism, during magnesium tocolytic therapy - Possible involvement of the calcium-sensing receptor. Nephrol Dial Transplant 1999, 14(7):1764-1766. 10.1093/ndt/14.7.1764, 10435892.
154. Monif GR, Savory J. Iatrogenic maternal hypocalcemia following magnesium sulfate therapy. JAMA 1972, 219(11):1469-1470. 10.1001/jama.1972.03190370059013, 5066903.
155. Nassar AH, Salti I, Makarem NN, Usta IM. Marked hypocalcemia after tocolytic magnesium sulphate therapy. Am J Perinatol 2007, 24(8):481-482. 10.1055/s-2007-986696, 17853341.
156. Ganzevoort JW, Hoogerwaard EM, van der Post JAM. Hypocalcemic delirium due to magnesium sulphate therapy in a pregnant woman with pre-eclampsia]. Ned Tijdschr Geneeskd 2002, 146(31):1453-1456.
157. Elliott JP, O'Keeffe DF, Greenberg P, Freeman RK. Pulmonary edema associated with magnesium sulfate and betamethasone administration. Am J Obstet Gynecol 1979, 134(6):717-719.
158. Worrell JA, Brunner JP, O'Donnell DM, Carroll FE. Pulmonary edema associated with tocolytic therapy. AJR Am J Roentgenol 1992, 158(6):1356-1357. 10.2214/ajr.158.6.1590140, 1590140.
159. Institute for Safe Medical Practices ISMP Medication Safety Alert. Enhance systems to ensure safe IV magnesium use http://www.ismp.org/Newsletters/acutecare/articles/19970212.asp, Institute for Safe Medical Practices.
160. Office of Safety & Quality in Healthcare Government of Western Australia Sharing Lessons Learned - Feb 2010. Preventing Magnesium Sulphate Overdose in Obstetric Settings http://www.safetyandquality.health.wa.gov.au/home/patient_news.cfm, Office of Safety & Quality in Healthcare Government of Western Australia.
161. Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol 2009, 33(3):130-137. 10.1053/j.semperi.2009.02.010, 19464502.
162. Tucker J, McGuire W. Epidemiology of preterm birth. BMJ 2004, 329:675-678. 10.1136/bmj.329.7467.675, 517653, 15374920.
163. Loke YK, Golder SP, Vandenbroucke JP. Comprehensive evaluations of the adverse effects of drugs: importance of appropriate study selection and data sources. Ther Adv Drug Saf 2011, 2(2):59-68.
164. Kremer L, Phillips R, Van-Dalen E. Tips and tricks for understanding and using SR results - no 13: adverse effects in systematic reviews. Evidence-Based Child Health 2009, 4:384-385.
165. Grimes D, Nanda K. Magnesium sulfate tocolysis: time to quit. Obstet Gynecol 2006, 108(4):986-989. 10.1097/01.AOG.0000236445.18265.93, 17012463.
166. U.S. Food and Drug Administration FDA recommends against prolonged use of magnesium sulfate to stop pre-term labor due to bone changes in exposed babies http://www.fda.gov/Drugs/DrugSafety/ucm353333.htm, U.S. Food and Drug Administration.
167. Ioannidis JPA. Adverse events in randomized trials: neglected, restricted, distorted, and silenced. Arch Intern Med 2009, 169(19):1737-1739. 10.1001/archinternmed.2009.313, 19858427.