-
1
-
-
84885805999
-
-
Cardiovascular disease. Available from Last accessed 17 May 2013
-
Cardiovascular disease. Available from: http://www.who.int/ cardiovascular- diseases/en/[Last accessed 17 May 2013]
-
-
-
-
3
-
-
84857743319
-
Diagnosing the decline in pharmaceutical R&D efficiency
-
In this paper, the decline in pharmaceutical R&D efficiency is diagnosed and four factors are considered to be primary causes of the inefficiency of new drugs R&D
-
Scannell JW, Blanckley A, Bolden H, Warrington B. Diagnosing the decline in pharmaceutical R&D efficiency. Nat Rev Drug Discov 2012;11(3):191-200 .. In this paper, the decline in pharmaceutical R&D efficiency is diagnosed and four factors are considered to be primary causes of the inefficiency of new drugs R&D.
-
(2012)
Nat Rev Drug Discov
, vol.11
, Issue.3
, pp. 191-200
-
-
Scannell, J.W.1
Blanckley, A.2
Bolden, H.3
Warrington, B.4
-
4
-
-
84855383596
-
A decade of change
-
Arrowsmith J. A decade of change. Nat Rev Drug Discov 2012;11(1):17-18
-
(2012)
Nat Rev Drug Discov
, vol.11
, Issue.1
, pp. 17-18
-
-
Arrowsmith, J.1
-
5
-
-
84855374173
-
2011 in reflection
-
Muller A. 2011 in reflection. Nat Rev Drug Discov 2012;11(1):6-8
-
(2012)
Nat Rev Drug Discov
, vol.11
, Issue.1
, pp. 6-8
-
-
Muller, A.1
-
6
-
-
58149400627
-
Discontinued drugs in 2007 cardiovascular drugs
-
Zhang XS, Xiang BR. Discontinued drugs in 2007: Cardiovascular drugs. Expert Opin Investig Drugs 2008;17(12):1817-28
-
(2008)
Expert Opin Investig Drugs
, vol.17
, Issue.12
, pp. 1817-1828
-
-
Zhang, X.S.1
Xiang, B.R.2
-
7
-
-
67650422376
-
Discontinued drugs in 2008 cardiovascular drugs
-
Zhang XS, Xiang BR. Discontinued drugs in 2008: Cardiovascular drugs. Expert Opin Investig Drugs 2009;18(7):875-85
-
(2009)
Expert Opin Investig Drugs
, vol.18
, Issue.7
, pp. 875-885
-
-
Zhang, X.S.1
Xiang, B.R.2
-
9
-
-
84866556006
-
Discontinued drugs in 2011: Cardiovascular drugs
-
10. 2012 First Half Financial Results. Available from Last accessed 18 May 2013
-
Zhao HP, Jiang HM, Xiang BR. Discontinued drugs in 2011: Cardiovascular drugs. Expert Opin Investig Drugs 2012;21(10):1449-62 10. 2012 First Half Financial Results. Available from: http://www.nicox.com/uploads/default/files// HY20120727EN1. pdf [Last accessed 18 May 2013]
-
(2012)
Expert Opin Investig Drugs
, vol.21
, Issue.10
, pp. 1449-1462
-
-
Zhao, H.P.1
Jiang, H.M.2
Xiang, B.R.3
-
10
-
-
84885748284
-
-
Veloxis Pharmaceuticals announces a restructuring of the company to support and strengthen strategic focus on LCP-Tacro- and announces changes to management. Available from
-
Veloxis Pharmaceuticals announces a restructuring of the company to support and strengthen strategic focus on LCP-Tacro- and announces changes to management. Available from: http://files. shareholder.com/downloads/ABEA- 4J4LWA/1879740064x0x571368/19fd6e2a-c671-49aa-bd75- 5bfddaa79103/ 230512%20Veloxis% 20Announces%20Restructuring%20of% 20Company.pdf [Last accessed 18 May 2013]
-
-
-
-
11
-
-
84885732933
-
-
Development activities. Available from [Last accessed 19 May 2013]
-
Development activities. Available from: http://www.takeda.com/company/ publications/pdf/index/pipeline-20121031-en.pdf [Last accessed 19 May 2013]
-
-
-
-
12
-
-
84885787167
-
-
Company presentation, Roche, 12 Apr 2012. Available from [Last accessed 19 May 2013]
-
Company presentation, Roche, 12 Apr 2012. Available from: http://www.roche.com/irp1q12e-a.pdf [Last accessed 19 May 2013]
-
-
-
-
13
-
-
84885825317
-
-
Roche Investor Presentation Q1 2011 Sales. Available from [Last accessed 19 May 2013]
-
Roche Investor Presentation Q1 2011 Sales. Available from: http://www.roche.com/irp1q11e.pdf [Last accessed 19 May 2013]
-
-
-
-
14
-
-
84885809452
-
-
Company presentation, Roche, 12 Apr 2012. Available from [Last accessed 19 May 2013]
-
Company presentation, Roche, 12 Apr 2012. Available from: http://www.roche.com/irp1q12e-a.pdf [Last accessed 19 May 2013]
-
-
-
-
15
-
-
84885786002
-
-
Ascending Dose Study of the Safety and Tolerability of REGN728 in Healthy Volunteers. Available from [Last accessed 19 May 2013]
-
Ascending Dose Study of the Safety and Tolerability of REGN728 in Healthy Volunteers. Available from: http://clinicaltrials.gov/ct2/show/NCT01197391? term=REGN- 728&rank=1 [Last accessed 19 May 2013]
-
-
-
-
16
-
-
84885790135
-
-
Form 10-Q, Regeneron, 24 Oct 2012. Available from [Last accessed 19 May 2013]
-
Form 10-Q, Regeneron, 24 Oct 2012. Available from: http://sec.gov/ Archives/edgar/data/872589/000153217612000004/regn-93012x10q. htm#sBD24B4DD64FB210E0CBD73 74D5F26B40 [Last accessed 19 May 2013]
-
-
-
-
17
-
-
77955888805
-
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3- cyclopentyl-3,3a,4,5- tetrahydro-2H-benzo [g]indazole-7-carboxylic acid (PF- 3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy
-
Meyers MJ, Arhancet GB, Hockerman SL, et al. Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3- cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo [g]indazole-7-carboxylic acid (PF- 3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. J Med Chem 2010;53(16):5979-6002
-
(2010)
J Med Chem
, vol.53
, Issue.16
, pp. 5979-6002
-
-
Meyers, M.J.1
Arhancet, G.B.2
Hockerman, S.L.3
-
18
-
-
84885816538
-
-
Multiple Dose Study in Healthy Volunteers to Assess Safety, Pharmacokinetics and Pharmacodynamics of PF 03882845. Available from [Last accessed 19 May 2013]
-
Multiple Dose Study in Healthy Volunteers to Assess Safety, Pharmacokinetics and Pharmacodynamics of PF 03882845. Available from: http://clinicaltrials.gov/ct2/resultsterm=NCT00856258&Search=Search [Last accessed 19 May 2013]
-
-
-
-
19
-
-
84885790228
-
-
Company pipeline, Pfizer, 8 Nov 2012. Available from [Last accessed 19 May 2013]
-
Company pipeline, Pfizer, 8 Nov 2012. Available from: http://www.pfizer.com/files/research/pipeline/2012-1108/pipeline-2012-1108.pdf [Last accessed 19 May 2013]
-
-
-
-
20
-
-
84885724803
-
-
Company pipeline, Mitsubishi, 8 May 2012. Available from [Last accessed 19 May 2013]
-
Company pipeline, Mitsubishi, 8 May 2012. Available from: http://www.mtpharma. co.jp/e/develop/pipeline/e-pipeline1203.pdf [Last accessed 19 May 2013]
-
-
-
-
21
-
-
84885703650
-
-
Company presentation, Cardiome, Apr 2012. Available from [Last accessed 19 May 2013]
-
Company presentation, Cardiome, Apr 2012. Available from: http://cardiome.com/sites/default/files/financials/pdf/ FINAL%20MD%26A%20FY%202011. pdf [Last accessed 19 May 2013]
-
-
-
-
22
-
-
84885695896
-
-
Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure. Available from [Last accessed 20 May 2013]
-
Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure. Available from: http://clinicaltrials.gov/ ct2/show/NCT01092325?term=CXL- 1020&rank=2 [Last accessed 20 May 2013]
-
-
-
-
23
-
-
84885762652
-
-
A Dose-Defining Study of CXL-1020 in Patients With Systolic Heart Failure. Available from [Last accessed 21 May 2013]
-
A Dose-Defining Study of CXL-1020 in Patients With Systolic Heart Failure. Available from: http://clinicaltrials.gov/ct2/show/NCT01096043?term= CXL- 1020&rank=1 [Last accessed 21 May 2013]
-
-
-
-
24
-
-
84885814444
-
-
IMPACTS Trial. Investigation of the Modulation of Phospholipase in Acute Chest Syndrome. Available from [Last accessed 21 May 2013]
-
IMPACTS Trial. Investigation of the Modulation of Phospholipase in Acute Chest Syndrome. Available from: http://clinicaltrials.gov/ct2/show/NCT00434473? term=ANSCD1121& rank=1 [Last accessed 21 May 2013]
-
-
-
-
25
-
-
84885783247
-
-
A Randomized Double-blind Placebo-Controlled Study With Varespladib Infusion (A-001) in Subjects With Sickle Cell Disease and Vaso-Occlusive Crisis for the Prevention of Acute Chest Syndrome At-Risk Subjects. Available from [Last accessed 29 July 2013]
-
A Randomized, Double-blind, Placebo-Controlled Study With Varespladib Infusion (A-001) in Subjects With Sickle Cell Disease and Vaso-Occlusive Crisis for the Prevention of Acute Chest Syndrome At-Risk Subjects. Available from: http://ichgcp.net/clinical-trials-registry/NCT01522196 [Last accessed 29 July 2013]
-
-
-
-
26
-
-
84885810260
-
-
Tezosentan in Patients With Pulmonary Arterial Hypertension. Available from [Last accessed 21 May 2013]
-
Tezosentan in Patients With Pulmonary Arterial Hypertension. Available from: http://clinicaltrials.gov/ct2/show/NCT01094067term=NCT01094067&rank=1 [Last accessed 21 May 2013]
-
-
-
-
27
-
-
84885811523
-
-
Tezosentan in Pulmonary Arterial Hypertension. Available from [Last accessed 22 May 2013]
-
Tezosentan in Pulmonary Arterial Hypertension. Available from: http://clinicaltrials.gov/ct2/show/record/NCT01077297term=NCT01077297&rank= 1 [Last accessed 22 May 2013]
-
-
-
-
28
-
-
84885747887
-
-
Phase III clinical trial of veletri for the treatment of acute heart failure symptoms does not meet primary efficacy objective. Available from [Last accessed 22 May 2013]
-
Phase III clinical trial of veletri for the treatment of acute heart failure symptoms does not meet primary efficacy objective. Available from: http://www1.actelion.com/en/investors/media-releases/index.page?newsId=1211970 [Last accessed 22 May 2013]
-
-
-
-
29
-
-
84885753497
-
-
Single Intravenous Administration of TB-402 for the Prophylaxis of Venous Thromboembolic Events (VTE) After Total Knee Replacement Surgery. Available from [Last accessed 24 July 2013]
-
Single Intravenous Administration of TB-402 for the Prophylaxis of Venous Thromboembolic Events (VTE) After Total Knee Replacement Surgery. Available from: http://clinicaltrials.gov/ct2/show/NCT00793234term=NCT00793234&rank=1 [Last accessed 24 July 2013]
-
-
-
-
30
-
-
84885812143
-
-
Single IV Administration of TB-402 for Prophylaxis of Venous Thromboembolic Events (VTE) After Total Hip Replacement Surgery. Available from [Last accessed 24 July 2013]
-
Single IV Administration of TB-402 for Prophylaxis of Venous Thromboembolic Events (VTE) After Total Hip Replacement Surgery. Available from: http://clinicaltrials.gov/ct2/show/NCT01344954term=NCT01344954&rank=1 [Last accessed 24 July 2013]
-
-
-
-
31
-
-
84885753250
-
-
Enrollment complete in ThromboGenics, BioInvent TB-402 Phase IIb trial on VTE. Available from [Last accessed 23 May 2013]
-
Enrollment complete in ThromboGenics, BioInvent TB-402 Phase IIb trial on VTE. Available from: http://www.newsmedical. net/news/20111217/ Enrollmentcomplete- in-ThromboGenics-BioInvent- TB-402-Phase-IIb-trial-on-VTE. aspx [Last accessed 23 May 2013]
-
-
-
-
32
-
-
84885771109
-
-
BioInvent, Thrombo Genics announce results from TB-402 Phase IIb trial on VTE. Available from [Last accessed 24 July 2013]
-
BioInvent, Thrombo Genics announce results from TB-402 Phase IIb trial on VTE. Available from: http://www.newsmedical.net/news/20120605/BioInvent- ThromboGenics-announce-results-from- TB-402-Phase-IIb-trial-on-VTE.aspx [Last accessed 24 July 2013]
-
-
-
-
33
-
-
84885737849
-
-
Form 10K, Spherix, 29 Mar 2012. Available from [Last accessed 30 July 2013]
-
Form 10K, Spherix, 29 Mar 2012. Available from: http://www.sec.gov/ Archives/edgar/data/12239/000110465912022224/a12-1151-110k. htm [Last accessed 30 July 2013]
-
-
-
-
34
-
-
84885794145
-
-
Spherix?s 2010 Annual Shareholder Meeting Script. Available from [Last accessed 23 May 2013]
-
Spherix?s 2010 Annual Shareholder Meeting Script. Available from: http://www.spherix.com/documents/MeetingScript2010-000.pdf [Last accessed 23 May 2013]
-
-
-
-
35
-
-
38049186809
-
Tagatose, a new antidiabetic and obesity control drug
-
Lu Y, Levin GV, Donner TW. Tagatose, a new antidiabetic and obesity control drug. Diabetes Obes Metab 2008;10(2):109-34
-
(2008)
Diabetes Obes Metab
, vol.10
, Issue.2
, pp. 109-134
-
-
Lu, Y.1
Levin, G.V.2
Donner, T.W.3
-
36
-
-
84885803369
-
-
Spherix Incorporated (Nasdaq: SPEX) January 2011. Available from [Last accessed 23 May 2013]
-
Spherix Incorporated (Nasdaq: SPEX) January 2011. Available from: http://www.spherix.com/documents/SPEXCorporatePresentation1-11-FINAL. pdf [Last accessed 23 May 2013]
-
-
-
-
37
-
-
84885726527
-
-
Japan Tobacco Inc Clinical development (as of October 31, 2011). Available from [Last accessed 23 May 2013]
-
Japan Tobacco Inc. Clinical development (as of October 31, 2011). Available from: http://www.jt.com/investors/results/pharmaceuticals/pdf/P.L. 20111031-E.pdf [Last accessed 23 May 2013]
-
-
-
-
38
-
-
84885713955
-
-
A Study to Evaluate the Safety, Tolerability, and Activity of Intravenous MLDL1278A in Patients on Standard-of-Care Therapy for Stable Atherosclerotic Cardiovascular Disease (GLACIER). Available from [Last accessed 24 July 2013]
-
A Study to Evaluate the Safety, Tolerability, and Activity of Intravenous MLDL1278A in Patients on Standard-of-Care Therapy for Stable Atherosclerotic Cardiovascular Disease (GLACIER). Available from: http://clinicaltrials.gov/ct2/ show/NCT01258907term=NCT01258907&rank=1 [Last accessed 24 July 2013]
-
-
-
-
39
-
-
84885716937
-
-
Announcement of topline results from the GLACIER study. Available from [Last accessed 23 May 2013]
-
Announcement of topline results from the GLACIER study. Available from: http://www.bioinvent.com/investors/press-releases/release.aspx? releaseid=682959 [Last accessed 23 May 2013]
-
-
-
-
40
-
-
84885830851
-
-
BioInvent Reports Positive Phase I Results for BI-204, in development for prevention of cardiovascular conditions associated with atherosclerosis Available from
-
BioInvent Reports Positive Phase I Results for BI-204, in development for prevention of cardiovascular conditions associated with atherosclerosis. Available from: http://www.bioinvent.com/mediacentre/press-releases/release. aspxreleaseid=424533
-
-
-
-
41
-
-
84885827228
-
-
A Multi-centre Study Comparing the Effects of AZD2927 and Placebo on the Electrical Activity in the Heart in Patients. Available from [Last accessed 28 May 2013]
-
A Multi-centre Study Comparing the Effects of AZD2927 and Placebo on the Electrical Activity in the Heart in Patients. Available from: http://clinicaltrials.gov/ct2/show/results/NCT01396226?term=AZD- 2927&rank=2§=X3015#evnt [Last accessed 28 May 2013]
-
-
-
-
42
-
-
84885759457
-
-
MeltDose- Technology Platform. Available from [Last accessed 29 May 2013]
-
MeltDose- Technology Platform. Available from: http://www.veloxis.com/ technology.cfm [Last accessed 29 May 2013]
-
-
-
-
43
-
-
84885783134
-
-
Pharmaceutical compositions comprising fenofibrate and atorvastatin. Available from [Last accessed 29 May 2013]
-
Pharmaceutical compositions comprising fenofibrate and atorvastatin. Available from: http://www.freshpatents.com/Pharmaceutical-compositions- comprisingfenofibrate- and-atorvastatindt20070118ptan20070014846. php [Last accessed 29 May 2013]
-
-
-
-
44
-
-
84885756849
-
-
LifeCycle Pharma Announces Positive Data from LCP-AtorFen Phase II Clinical Program Available from
-
LifeCycle Pharma Announces Positive Data from LCP-AtorFen Phase II Clinical Program. Available from: http://www.drugs.com/clinical-trials/ lifecyclepharma- announces-positive-data-lcpatorfen- phase-ii-clinical-program- 4190. html
-
-
-
-
45
-
-
84885783145
-
-
Veloxis Pharmaceuticals announces a restructuring of the company to support and strengthen strategic focus on LCP-Tacro- and announces changes to management. Available from [Last accessed 30 July 2013]
-
Veloxis Pharmaceuticals announces a restructuring of the company to support and strengthen strategic focus on LCP-Tacro- and announces changes to management. Available from: http://files. shareholder.com/downloads/ABEA- 4J4LWA/1879740064x0x571368/19fd6e2a-c671-49aa-bd75- 5bfddaa79103/ 230512%20Veloxis% 20Announces%20Restructuring%20of% 20Company.pdf [Last accessed 30 July 2013]
-
-
-
-
46
-
-
84885784823
-
-
Eisai heart drug looks safe in mid-stage trials. Available from [Last accessed 6 June 2013]
-
Eisai heart drug looks safe in mid-stage trials. Available from: http://www.reuters.com/article/2010/08/30/heart-eisaiidUSLDE67T0IH20100830 [Last accessed 6 June 2013]
-
-
-
-
47
-
-
84885759603
-
-
A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab-) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock. Available from [Last accessed 24 July 2013]
-
A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab-) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock. Available from: http://clinicaltrials.gov/ct2/show/ NCT01145560term=NCT01145560&rank=1 [Last accessed 24 July 2013]
-
-
-
-
48
-
-
84885780365
-
-
BTG Announces Data from Phase IIb Study of AZD9773. Available from [Last accessed 6 June 2013]
-
BTG Announces Data from Phase IIb Study of AZD9773. Available from: http://www.btgplc.com/page/21061/media/press-releases/2012/btg-announcesdata- from-phase-iib-study-of-azd9773[Last accessed6June2013]
-
-
-
-
49
-
-
84885828718
-
-
Essential Hypertension Available From (REDUCE-1). Last Accessed 24 July 2013]
-
Essential Hypertension (REDUCE-1). Available from: http://clinicaltrials. gov/ct2/show/NCT01264692term=NCT01264692&rank=1 [Last accessed 24 July 2013]
-
-
-
-
50
-
-
84885783762
-
-
Actelion announces first quarter 2012 financial results. Available from [Last accessed 6 June 2013]
-
Actelion announces first quarter 2012 financial results. Available from: http://www.actelion.com/en/investors/media-releases/index.page? newsId=1603781 [Last accessed 6 June 2013]
-
-
-
-
51
-
-
84885821747
-
-
TC-5214 as Augmentation Therapy in Patients With Refractory Hypertension. Available from [Last accessed 24 July 2013]
-
TC-5214 as Augmentation Therapy in Patients With Refractory Hypertension. Available from: http://clinicaltrials.gov/ct2/show/NCT00899977term= NCT00899977&rank=1 [Last accessed 24 July 2013]
-
-
-
-
52
-
-
84885796717
-
-
TC-5214 as Augmentation Therapy in Patients With Refractory Hypertension. Available from [Last accessed 7 June 2013]
-
TC-5214 as Augmentation Therapy in Patients With Refractory Hypertension. Available from: http://clinicaltrials.gov/ct2/show/NCT00899977?term=TC- 5214&rank=7 [Last accessed 7 June 2013]
-
-
-
-
53
-
-
84885699028
-
-
AstraZeneca updates on olaparib and TC-5214 development programmes. Available from [Last accessed 30 July 2013]
-
AstraZeneca updates on olaparib and TC-5214 development programmes. Available from: http://www.astrazeneca.com/Media/Press-releases/Article/ 20111220-az-updates-olaparib-TC5214- development [Last accessed 30 July 2013]
-
-
-
-
54
-
-
84885765763
-
-
Remaining TC-5214 Phase III efficacy studies do not meet endpoint, regulatory filing will not be pursued. Available from [Last accessed 6 June 2013]
-
Remaining TC-5214 Phase III efficacy studies do not meet endpoint, regulatory filing will not be pursued. Available from: http://www.astrazeneca. com/Media/Press-releases/Article/20032012tc5214-failed-phase-iiiendpoint [Last accessed 6 June 2013]
-
-
-
-
55
-
-
60249101701
-
Effects of 1-H-indole-3-glyoxamide (A-002 on concentration of secretory phospholipase A 2) (PLASMA study): A phase II double-blind, randomised, placebo-controlled trial
-
Rosenson RS, Hislop C, McConnell D, et al. Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A(2) (PLASMA study): A phase II double-blind, randomised, placebo-controlled trial. Lancet 2009;373(9664):649-58
-
(2009)
Lancet
, vol.373
, Issue.9664
, pp. 649-658
-
-
Rosenson, R.S.1
Hislop, C.2
McConnell, D.3
-
56
-
-
84885760740
-
-
Anthera Halts VISTA-16 Clinical Study Due to Lack of Efficacy Following Recommendation by the Independent Data Safety Monitoring Board. Available from [Last accessed 7 June 2013]
-
Anthera Halts VISTA-16 Clinical Study Due to Lack of Efficacy Following Recommendation by the Independent Data Safety Monitoring Board. Available from: http://cn.reuters.com/article/pressRelease/idUS238189+09-Mar-2012 +PRN20120309?symbol=ANTH.OQ [Last accessed 7 June 2013]
-
-
-
-
57
-
-
84885775320
-
-
Form 10-Q, Merck, 9 Nov 2012. Available from [Last accessed 14 June 2013]
-
Form 10-Q, Merck, 9 Nov 2012. Available from: http://www.sec.gov/ Archives/edgar/data/310158/000119312512463586/d400394d10q. htm [Last accessed 14 June 2013]
-
-
-
-
58
-
-
84885719981
-
-
Chrysalin (Rusalatide Acetate, TP508) Pre-Clinical Results Show Significant Beneficial Effect in Chronic Heart Disease. Available from [Last accessed 30 July 2013]
-
Chrysalin (Rusalatide Acetate, TP508) Pre-Clinical Results Show Significant Beneficial Effect in Chronic Heart Disease. Available from: http://cn.reuters.com/article/pressRelease/idUS124947+03- Sep-2008+GNW20080903? sp=true [Last accessed 30 July 2013]
-
-
-
-
59
-
-
55249122720
-
Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair?
-
Carney DH, Olszewska-Pazdrak B. Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair? Expert Opin Pharmacother 2008;9(15):2717-26
-
(2008)
Expert Opin Pharmacother
, vol.9
, Issue.15
, pp. 2717-2726
-
-
Carney, D.H.1
Olszewska-Pazdrak, B.2
-
60
-
-
84885710210
-
-
Capstone Therapeutics Announces Operational Update. Available from [Last accessed 14 June 2013]
-
Capstone Therapeutics Announces Operational Update. Available from: http://files.shareholder.com/downloads/OLGC/1650916856x0x535254/ 6a0b4efc-de04-405f-84f7-4810ead2d08d/CAPS-News-2012-1-20-General- Releases.pdf [Last accessed 14 June 2013]
-
-
-
-
61
-
-
84885754384
-
-
Efficacy Study of Iferanserin to Treat Hemorrhoids. Available from [Last accessed 24 July 2013]
-
Efficacy Study of Iferanserin to Treat Hemorrhoids. Available from: http://clinicaltrials.gov/ct2/show/NCT01483833term=NCT01483833&rank=1 [Last accessed 24 July 2013]
-
-
-
-
62
-
-
84885715808
-
-
Ventrus Announces Publication of Prior Phase 2b Study on the Safety and Efficacy of Iferanserin in the Treatment of Hemorrhoid Disease. Available from [Last accessed 27 July 2013]
-
Ventrus Announces Publication of Prior Phase 2b Study on the Safety and Efficacy of Iferanserin in the Treatment of Hemorrhoid Disease. Available from: http://investor.ventrusbio.com/releasedetail.cfm?ReleaseID=639247 [Last accessed 27 July 2013]
-
-
-
-
63
-
-
84885822636
-
-
S-1/A 1 v196825-s1a.htm. Available from [Last accessed 13 June 2013]
-
S-1/A 1 v196825-s1a.htm. Available from: http://www.sec.gov/Archives/ edgar/data/1426800/000114420410052266/v196825-s1a.htm [Last accessed 13 June 2013]
-
-
-
-
64
-
-
84885810463
-
-
Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids (VEN309). Available from [Last accessed 24 July 2013]
-
Efficacy and Safety Study to Treat Subjects With Symptomatic Internal Hemorrhoids (VEN309). Available from: http://clinicaltrials.gov/ct2/show/ NCT01355874term=NCT01355874&rank=1 [Last accessed 24 July 2013]
-
-
-
-
65
-
-
84885769914
-
-
Ventrus Biosciences Announces Results From Pivotal Phase 3 Trial of Iferanserin (VEN 309) in Patients With Hemorrhoidal Disease. Available from [Last accessed 13 June 2013]
-
Ventrus Biosciences Announces Results From Pivotal Phase 3 Trial of Iferanserin (VEN 309) in Patients With Hemorrhoidal Disease. Available from: http://investor.ventrusbio.com/releasedetail.cfm?ReleaseID=686060 [Last accessed 13 June 2013]
-
-
-
-
66
-
-
84885773395
-
-
Efficacy and Safety Study of Eprotirome in HeFH Patients Who Are on Optimal Standard of Care (AKKA). Available from [Last accessed 24 July 2013]
-
Efficacy and Safety Study of Eprotirome in HeFH Patients Who Are on Optimal Standard of Care (AKKA). Available from: http://clinicaltrials.gov/ct2/ show/NCT01410383term=NCT01410383&rank=1 [Last accessed 24 July 2013]
-
-
-
-
67
-
-
84885820509
-
-
KARO BIO TERMINATES THE EPROTIROME PROGRAM. Available from [Last accessed 13 June 2013]
-
KARO BIO TERMINATES THE EPROTIROME PROGRAM. Available from: http://www.karobio.com/investormedia/pressreleaser/pressrelease? pid=639535 [Last accessed 13 June 2013]
-
-
-
-
68
-
-
84885803995
-
-
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI (ASPECT). Available from [Last accessed 24 July 2013]
-
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI (ASPECT). Available from: http://clinicaltrials.gov/ct2/show/NCT00990327term=NCT00990327&rank=1 [Last accessed 24 July 2013]
-
-
-
-
69
-
-
84885776882
-
-
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI (ASPECT2). Available from [Last accessed 24 July 2013]
-
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI (ASPECT2). Available from: http://clinicaltrials.gov/ct2/show/NCT01313572term=NCT01313572&rank=1 [Last accessed 24 July 2013]
-
-
-
-
70
-
-
84885775861
-
-
A Comparison Study of Apadenoson and Adenosine to Treadmill Exercise Stress. Available from [Last accessed 24 July 2013]
-
A Comparison Study of Apadenoson and Adenosine to Treadmill Exercise Stress. Available from: http://clinicaltrials.gov/ct2/show/NCT00380198term= NCT00380198&rank=1 [Last accessed 24 July 2013]
-
-
-
-
71
-
-
84885744974
-
-
A Study to Examine MPI SPECT Imaging With BMS068645 and Adenosine Compared to Coronary Angiography. Available from [Last accessed 24 July 2013]
-
A Study to Examine MPI SPECT Imaging With BMS068645 and Adenosine Compared to Coronary Angiography. Available from: http://clinicaltrials.gov/ct2/ show/NCT00162084term=NCT00162084&rank=1 [Last accessed 24 July 2013]
-
-
-
-
72
-
-
84885781538
-
-
Forest Laboratories 2012 Annual Report. Available from [Last accessed 10 June 2013]
-
Forest Laboratories 2012 Annual Report. Available from: http://investor.frx.com/sites/frx.investorhq.businesswire.com/files/report/file/ Full-Report.pdf [Last accessed 10 June 2013]
-
-
-
-
73
-
-
33644748228
-
Academia given a helping hand in drug development
-
Branca MA. Academia given a helping hand in drug development. Nat Rev Drug Discov 2006;5:177
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 177
-
-
Branca, M.A.1
-
74
-
-
54249107905
-
Failure is an option: Learning from unsuccessful proof-of-concept trials
-
This paper gives some insightful advice on how to reduce Phase II disappointments
-
Scha?fer S, Kolkhof P. Failure is an option: Learning from unsuccessful proof-of-concept trials. Drug Discov Today 2008;13:913-16 . This paper gives some insightful advice on how to reduce Phase II disappointments.
-
(2008)
Drug Discov Today
, vol.13
, pp. 913-916
-
-
Schafer, S.1
Kolkhof, P.2
-
75
-
-
40049110428
-
Drug approvals and failures: Implications for alliances
-
Czerepak EA, Ryser S. Drug approvals and failures: Implications for alliances. Nat Rev Drug Discov 2008;7:197-8
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 197-198
-
-
Czerepak, E.A.1
Ryser, S.2
-
76
-
-
77957750242
-
Emerging trends in contract research industry in India
-
Drabu S, Gupta A, Bhadauria A. Emerging trends in contract research industry in India. Contemp Clin Trials 2010;31:419-22
-
(2010)
Contemp Clin Trials
, vol.31
, pp. 419-422
-
-
Drabu, S.1
Gupta, A.2
Bhadauria, A.3
-
77
-
-
80052218993
-
Drug repositioning: Re-investigating existing drugs for new therapeutic indications
-
Padhy BM, Gupta YK. Drug repositioning: Re-investigating existing drugs for new therapeutic indications. J Postgrad Med 2011;57:153-60
-
(2011)
J Postgrad Med
, vol.57
, pp. 153-160
-
-
Padhy, B.M.1
Gupta, Y.K.2
|