Comparative pharmacokinetics of five rhubarb anthraquinones in normal and thrombotic focal cerebral ischemia-induced rats

Phytotherapy Research

Volumn 27, Issue 10, 2013, Pages 1489-1494

  Feng, Su Xiang ^a,b   Li, Jian Sheng ^b   Qu, Ling Bo ^a,c   Shi, Yan Mei ^a   Zhao, Di ^b  

^a ZHENGZHOU UNIVERSITY   (China)

^b HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

^c HENAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

anthraquinones; normal rats; pharmacokinetics comparison; rhubarb extract; thrombotic focal cerebral ischemia induced rats

Indexed keywords

ALOE EMODIN; CHRYSOPHANIC ACID; EMODIN; PHYSCION; RHEIN; RHUBARB EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ALOE; RATTUS; RHEUM PALMATUM; RHEUM X HYBRIDUM;

ANTHRAQUINONES; NORMAL RATS; PHARMACOKINETICS COMPARISON; RHUBARB EXTRACT; THROMBOTIC FOCAL CEREBRAL ISCHEMIA-INDUCED RATS;

ANIMALS; ANTHRAQUINONES; BRAIN ISCHEMIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; EMODIN; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RHEUM;

EID: 84885667812     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4890     Document Type: Article

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