Clusterin associates specifically with aβ40 in alzheimer's disease brain tissue

Brain Pathology

Volumn 23, Issue 6, 2013, Pages 623-632

  Howlett, David R ^a   Hortobágyi, Tibor ^a,b   Francis, Paul T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Alzheimer's disease; amyloid beta protein; apolipoprotein J; biomarker; clusterin

Indexed keywords

AMYLOID BETA PROTEIN 40 ANTIBODY; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CLUSTERIN; CLUSTERIN ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANTIBODY LABELING; ARTICLE; BRAIN BLOOD VESSEL; BRAIN CORTEX; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; SENILE PLAQUE;

ALZHEIMER'S DISEASE; AMYLOID BETA-PROTEIN; APOLIPOPROTEIN J; BIOMARKER; CLUSTERIN;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CEREBRAL CORTEX; CLUSTERIN; FEMALE; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; YOUNG ADULT;

EID: 84885664791     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12057     Document Type: Article

References (27)

1. Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, et al (2002) Brain clearance of Alzheimer's amyloid-beta 40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target 10: 359-368.
2. Braak H, Braak E, (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239-259.
3. Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, et al (1999) Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J 344: 375-383.
4. Fritz IB, Burdzy K, Setchell B, Blasckuk O, (1983) Ram rete testis fluid contains a protein (clusterin) which influences cell-cell interaction in vitro. Biol Reprod 28: 1173-1188.
5. Giannakopoulos P, Kovari E, French LE, Viard I, Hof PR, Bouras C, (1998) Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol 95: 387-394.
6. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, et al (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 41: 1088-1093.
7. Howlett DR, Bowler K, Soden PE, Riddell D, Davis JB, Richardson JC, et al (2008) Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease. Histol Histopathol 23: 67-76.
8. Howlett DR, Richardson JC, Austin A, Parsons AA, Bate ST, Davies DC, et al (2004) Cognitive correlates of A beta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes. Brain Res 1017: 130-136.
9. Iwatsubo T, Saido TC, Mann DMA, Lee VMY, Trojanowski JQ, (1996) Full-length amyloid-beta(1-42(43)) and amino-terminally modified and truncated amyloid-beta-42(43) deposit in diffuse plaques. Am J Pathol 149: 1823-1830.
10. Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, et al (2013) Clusterin regulates b-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry. doi: 10.1038/mp.2012.163.
11. Kitamoto T, Ogomori K, Tateishi J, Prusiner SB, (1987) Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest 57: 230-236.
12. Koch-Brandt C, Morgans C, (1996) Clusterin: a role in cell survival in the face of apoptosis? Prog Mol Subcell Biol 16: 130-149.
13. Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41: 1094-1099.
14. Lovestone S, Guntert A, Hye A, Lynham S, Thambisetty M, Ward M, (2007) Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers. Expert Rev Proteomics 4: 227-238.
15. Mann DM, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, et al (1996) Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. Am J Pathol 148: 1257-1266.
16. McGeer PL, Kawamata T, Walker DG, (1992) Distribution of clusterin in Alzheimer brain tissue. Brain Res 579: 337-341.
17. Miller DL, Potempska A, Wegiel J, Mehta PD, (2011) High-affinity rabbit monoclonal antibodies specific for amyloid peptides amyloid-40 and amyloid-42. J Alzheimer Dis 23: 293-305.
18. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41: 479-486.
19. Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, et al (2012) The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-beta(1-40) peptide. Nat Struct Mol Biol 19: 79-83.
20. Oda T, Pasinetti GM, Osterburg HH, Anderson C, Johnson SA, Finch CE, (1994) Purification and characterization of brain clusterin. Biochem Biophys Res Commun 204: 1131-1136.
21. Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, et al (2000) Clearance of Alzheimer's amyloid-beta(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106: 1489-1499.
22. Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, et al (2000) Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. Am J Pathol 156: 489-499.
23. Suzuki N, Iwatsubo T, Odaka A, Ishibashi Y, Kitada C, Ihara Y, (1994) High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. Am J Pathol 145: 452-460.
24. Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, et al (2010) Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry 67: 739-748.
25. Tomic JL, Pensalfini A, Head E, Glabe CG, (2009) Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis 35: 352-358.
26. Xuereb JH, Brayne C, Dufouil C, Gertz H, Wischik C, Harrington C, et al (2000) Neuropathological findings in the very old. Results from the first 101 brains of a population-based longitudinal study of dementing disorders. Annals N Y Acad Sci 903: 490-496.
27. Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Harigaya Y, (1988) Diffuse type of senile plaques in the brains of Alzheimer-type dementia. Acta Neuropathol 77: 113-119.