Neuropeptide y and peptide YY protect from weight loss caused by Bacille Calmette-Guérin in mice

British Journal of Pharmacology

Volumn 170, Issue 5, 2013, Pages 1014-1026

  Painsipp, Evelin ^a   Köfer, Martin J ^a   Farzi, Aitak ^a   Dischinger, Ulrich S ^a   Sinner, Frank ^b   Herzog, Herbert ^c   Holzer, Peter ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b JOANNEUM RESEARCH   (Austria)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Bacille Calmette Gu rin; corticosterone; exploration; food intake; IL 6; immune stimulation; locomotion; neuropeptide Y; peptide YY; sickness behaviour

Indexed keywords

BCG VACCINE; CORTICOSTERONE; INTERLEUKIN 6; NEUROPEPTIDE Y; PEPTIDE YY;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; C57BL 6 MOUSE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENERGY BALANCE; EXPLORATORY BEHAVIOR; FEVER; FLUID INTAKE; FOOD INTAKE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOSTIMULATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; WEIGHT REDUCTION;

BACILLE CALMETTE-GUÉRIN; CORTICOSTERONE; EXPLORATION; FOOD INTAKE; IL-6; IMMUNE STIMULATION; LOCOMOTION; NEUROPEPTIDE Y; PEPTIDE YY; SICKNESS BEHAVIOUR;

ANIMALS; BCG VACCINE; BEHAVIOR, ANIMAL; CIRCADIAN RHYTHM; CORTICOSTERONE; EATING; ENERGY METABOLISM; EXPLORATORY BEHAVIOR; FEMALE; INTERLEUKIN-6; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEUROPEPTIDE Y; PEPTIDE YY; TIME FACTORS; WEIGHT LOSS;

EID: 84885641518     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12354     Document Type: Article

References (41)

1. Alexander SPH, Mathie A, Peters JA, (2011). Guide to receptors and channels (GRAC), 5th edn. Br J Pharmacol 164 (Suppl. 1): S1-S324.
2. Allie N, Alexopoulou L, Quesniaux VJ, Fick L, Kranidioti K, Kollias G, et al. (2008). Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection. Immunology 125: 522-534.
3. Bannon AW, Seda J, Carmouche M, Francis JM, Norman MH, Karbon B, et al. (2000). Behavioral characterization of neuropeptide Y knockout mice. Brain Res 868: 79-87.
4. Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, et al. (2006). Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 4: 223-233.
5. Boey D, Lin S, Karl T, Baldock P, Lee N, Enriquez R, et al. (2006). Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity. Diabetologia 49: 1360-1370.
6. Brabham T, Phelka A, Zimmer C, Nash A, Lõpez JF, Vázquez DM, (2000). Effects of prenatal dexamethasone on spatial learning and response to stress is influenced by maternal factors. Am J Physiol 279: R1899-R1909.
7. Braun TP, Marks DL, (2011). Hypothalamic regulation of muscle metabolism. Curr Opin Clin Nutr Metab Care 14: 237-242.
8. Braun TP, Zhu X, Szumowski M, Scott GD, Grossberg AJ, Levasseur PR, et al. (2011). Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis. J Exp Med 208: 2449-2463.
9. Célérier A, Piérard C, Rachbauer D, Sarrieau A, Béracochéa D, (2004). Contextual and serial discriminations: a new learning paradigm to assess simultaneously the effects of acute stress on retrieval of flexible or stable information in mice. Learn Mem 11: 196-204.
10. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW, (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9: 46-56.
11. Edelsbrunner ME, Herzog H, Holzer P, (2009). Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent manner. Behav Brain Res 203: 97-107.
12. Erickson JC, Clegg KE, Palmiter RD, (1996). Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381: 415-421.
13. Forbes S, Herzog H, Cox HM, (2012). A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress. Br J Pharmacol 166: 2307-2316.
14. Gehlert DR, (1999). Role of hypothalamic neuropeptide Y in feeding and obesity. Neuropeptides 33: 329-338.
15. Gibb J, Hayley S, Gandhi R, Poulter MO, Anisman H, (2008). Synergistic and additive actions of a psychosocial stressor and endotoxin challenge: circulating and brain cytokines, plasma corticosterone and behavioral changes in mice. Brain Behav Immun 22: 573-589.
16. Goehler LE, Gaykema RPA, Hansen MK, Anderson K, Maier SF, Watkins LR, (2000). Vagal immune-to-brain communication: a visceral chemosensory pathway. Auton Neurosci 85: 49-59.
17. Haroon E, Raison CL, Miller AH, (2012). Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37: 137-162.
18. Harrington M, Molyneux P, Soscia S, Prabakar C, McKinley-Brewer J, Lall G, (2007). Behavioral and neurochemical sources of variability of circadian period and phase: studies of circadian rhythms of NPY-/- mice. Am J Physiol 292: R1306-R1314.
19. Heilig M, (2004). The NPY system in stress, anxiety and depression. Neuropeptides 38: 213-224.
20. Herzog H, (2003). Neuropeptide Y and energy homeostasis: insights from Y receptor knockout models. Eur J Pharmacol 480: 21-29.
21. Hirsch D, Zukowska Z, (2012). NPY and stress 30 years later: the peripheral view. Cell Mol Neurobiol 32: 645-659.
22. Huygen K, Vandenbussche P, Heremans H, (1991). Interleukin-6 production in Mycobacterium bovis BCG-infected mice. Cell Immunol 137: 224-231.
23. Karl T, Duffy L, Herzog H, (2008). Behavioural profile of a new mouse model for NPY deficiency. Eur J Neurosci 28: 173-180.
24. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
25. Leal IS, Flõrido M, Andersen P, Appelberg R, (2001). Interleukin-6 regulates the phenotype of the immune response to a tuberculosis subunit vaccine. Immunology 103: 375-381.
26. Lin S, Boey D, Herzog H, (2004). NPY and Y receptors: lessons from transgenic and knockout models. Neuropeptides 38: 189-200.
27. McEwen BS, (2007). Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87: 873-904.
28. McGowan BMC, Bloom SR, (2004). Peptide YY and appetite control. Curr Opin Pharmacol 4: 583-588.
29. McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
30. Morales-Medina JC, Dumont Y, Quirion R, (2010). A possible role of neuropeptide Y in depression and stress. Brain Res 1314: 194-205.
31. Moreau M, André C, O'Connor JC, Dumich SA, Woods JA, Kelley KW, et al. (2008). Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior. Brain Behav Immun 22: 1087-1095.
32. O'Connor JC, André C, Wang Y, Lawson MA, Szegedi SS, Lestage J, et al. (2009a). Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci 29: 4200-4209.
33. O'Connor JC, Lawson MA, André C, Briley EM, Szegedi SS, Lestage J, et al. (2009b). Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior. J Immunol 182: 3202-3212.
34. Painsipp E, Herzog H, Holzer P, (2008). Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice. Neuropharmacology 55: 117-126.
35. Painsipp E, Herzog H, Holzer P, (2010). Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge. J Psychopharmacol 24: 1551-1560.
36. Painsipp E, Herzog H, Sperk G, Holzer P, (2011). Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y. Br J Pharmacol 163: 1302-1314.
37. Sander B, Skansén-Saphir U, Damm O, Håkansson L, Andersson J, Andersson U, (1995). Sequential production of Th1 and Th2 cytokines in response to live bacillus Calmette-Guérin. Immunology 86: 512-518.
38. Ueno H, Yamaguchi H, Mizuta M, Nakazato M, (2008). The role of PYY in feeding regulation. Regul Pept 145: 12-16.
39. Vázquez DM, (1998). Stress and the developing limbic-hypothalamic- pituitary-adrenal axis. Psychoneuroendocrinology 23: 663-700.
40. Wheway J, Herzog H, Mackay F, (2007). NPY and receptors in immune and inflammatory diseases. Curr Top Med Chem 7: 1743-1752.
41. Zhang L, Nguyen AD, Lee IC, Yulyaningsih E, Riepler SJ, Stehrer B, et al. (2012). NPY modulates PYY function in the regulation of energy balance and glucose homeostasis. Diabetes Obes Metab 14: 727-736.