S100B protein may detect brain death development after severe traumatic brain injury

Journal of Neurotrauma

Volumn 30, Issue 20, 2013, Pages 1762-1769

  Egea Guerrero, Juan J ^a   Murillo Cabezas, Francisco ^a   Gordillo Escobar, Elena ^a   Rodríguez Rodríguez, Ana ^a   Enamorado Enamorado, Judy ^a   Revuelto Rey, Jaume ^a   Pacheco Sánchez, María ^a   León Justel, Antonio ^a   Domínguez Roldán, Jose M ^a   Vilches Arenas, Angel ^b  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

BD; biomarkers; S100B protein; TBI

Indexed keywords

BIOLOGICAL MARKER; PROTEIN S100B;

ADULT; ARTICLE; BRAIN DEATH; EARLY DIAGNOSIS; GLASGOW COMA SCALE; HIGH RISK PATIENT; HUMAN; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MYDRIASIS; PREDICTIVE VALUE; PROGNOSIS; PROTEIN BLOOD LEVEL; PUPIL REFLEX; SCREENING TEST; SENSITIVITY AND SPECIFICITY; TRAUMATIC BRAIN INJURY;

ADOLESCENT; ADULT; BRAIN DEATH; BRAIN INJURIES; EARLY DIAGNOSIS; FEMALE; GLASGOW COMA SCALE; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PUPIL; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; SENSITIVITY AND SPECIFICITY; TISSUE DONORS;

EID: 84885619778     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2606     Document Type: Article

References (49)

1. Meers, C., Van Raemdonck, D., Van Gelder, F., Van Hees, D., Desschans, B., De Roey, J., Vanhaecke, J., Pirenne, J., and UZ Leuven Council for Transplantation (2009). Change in donor profile influenced the percentage of organs transplanted from multiple organ donors. Transplant. Proc. 41, 572-575
2. Kompanje, E.J., de Groot, Y.J., and Bakker, J. (2011). Is organ donation from brain dead donors reaching an inescapable and desirable nadir? Transplantation 91, 1177-1180
3. Salim, A., Berry, C., Ley, E.J., Schulman, D., Desai, C., Navarro, S., and Malinoski, D. (2011). In-house coordinator programs improve conversion rates for organ donation. J. Trauma 71, 733-736
4. Mar?́n-Caballos, A.J., Murillo-Cabezas, F., Cayuela-Dom? ́nguez, A., Dom?́nguez-Roldán, J.M., Rincón-Ferrari, M.D., Valencia-Anguita, J., Flores-Cordero, J.M., and Mun?oz-Sánchez, M.A.(2005). Cerebral perfusion pressure and risk of brain hypoxia in severe head injury: A prospective observational study. Crit. Care. 9, R670-676
5. Leal-Noval, S.R., Cayuela, A., Arellano-Orden, V., Mar?́n-Caballos, A., Padilla, V., Ferrándiz-Millón, C., Corcia, Y., Garc?́a-Alfaro, C., Amaya-Villar, R., and Murillo-Cabezas, F. (2010). Invasive and noninvasive assessment of cerebral oxygenation in patients with severe traumatic brain injury. Intensive Care Med. 36, 1309-1317
6. Haddad, S., Aldawood, A.S., Alferayan, A., Russell, N.A., Tamim, H.M., and Arabi, Y.M. (2011). Relationship between intracranial pressure monitoring and outcomes in severe traumatic brain injury patients. Anaesth. Intensive Care 39, 1043-1050
7. Dom?́nguez-Roldán, J.M., Barrera-Chacon, J.M., Martin-Bermudez, R., Murillo-Cabezas, F., Garcia-Alfaro, C., and Rincon-Ferrari, M.D. (1999). Changes in the intracranial pulse pressure waveform associated with brain death. Transplant Proc. 31, 2957-2958
8. Figaji, A.A., and Kent, S.J. (2010). Brain tissue oxygenation in children diagnosed with brain death. Neurocrit. Care 12, 56-61
9. Egea-Guerrero, J.J., Gordillo-Escobar, E., Revuelto-Rey, J., Enamorado- Enamorado, J., Vilches-Arenas, A., Pacheco-Sánchez, M., Dom?́nguez-Roldán, J.M., and Murillo-Cabezas, F. (2012) Clinical variables and neuromonitoring information (intracranial pressure and brain tissue oxygenation) as predictors of brain death development after severe traumatic brain injury. Transplant Proc. 44, 2050-2052
10. Raabe, A., and Seifert, V. (1999). Fatal secondary increase in serum S- 100B protein after severe head injury. Report of three cases. J. Neurosurg. 91, 875-877
11. Regner, A., Kaufman, M., Friedman, G., and Chemale I. (2001). Increased serum S100beta protein concentrations following severe head injury in humans: A biochemical marker of brain death? Neuroreport 26, 691-694
12. Dimopoulou, I., Korfias, S., Dafni, U., Anthi, A., Psachoulia, C., Jullien, G., Sakas, D.E., and Roussos, C. (2003). Protein S-100b serum levels in trauma induced brain death. Neurology 60, 947-951
13. Jensen, R., Marshak, D.R., Anderson, C., Lukas, T.J., and Watterson, D.M. (1985). Characterization of human brain S100 protein fraction: Amino acid sequence of S100 beta. J. Neurochem. 45, 700-705
14. Chen, Y., and Swanson, R.A. (2003). Astrocytes and brain injury. J. Cereb. Blood Flow Metab. 23, 137-139
15. Donato, R., and Heizmann, C.W. (2010). S100B protein in the nervous system and cardiovascular apparatus in normal and pathological conditions. Cardiovasc. Psychiatry Neurol. 92, 87-92
16. Anderson, R.E., Hansson, L.-O., Nilsson, O., Dijlai-Merzoug, R., and Settergren, G. (2001). High serum S100B levels for trauma patients without head injuries. Neurosurgery 48, 1255-1260
17. Pelinka, L.E., Szalay, L., Jafarmadar, M., Schmidhammer, R., Redl, H., and Bahrami, S. (2003). Circulating S100B is increased after bilateral femur fracture without brain injury in the rat. Br. J. Anaesth. 91, 595-597
18. Bloomfield, S.M., McKinney, J., Smith, L., and Brisman, J. (2007). Reliability of S100B in predicting severity of central nervous system injury. Neurocrit. Care 6, 121-138
19. Egea-Guerrero, J.J., Revuelto-Rey, J., Murillo-Cabezas, F., Mun?oz- Sánchez, M.A., Vilches-Arenas, A., Sánchez-Linares, P., Dom? ́nguez-Roldán, J.M., and León-Carrión, J. (2012). Accuracy of the S100b protein as a marker of brain damage in traumatic brain injury. Brain Inj. 26, 76-82
20. Raabe, A., and Seifert, V. (2000). Protein S-100B as a serum marker of brain damage in severe head injury: Preliminary results. Neurosurg. Rev. 23, 136-138
21. Pleines, U.E., Morganti-Kossmann, M.C., Rancan, M., Joller, H., Trentz, O., and Kossmann, T. (2001). S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J. Neurotrauma 18, 491-498
22. Mussack, T., Biberthaler, P., Kanz, K.G., Wiedemann, E., Gippner- Steppert, C., Mutschler, W., and Jochum, M. (2002). Serum S-100B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Crit. Care Med. 30, 2669-2674
23. Vos, P.E., Lamers, K.J., Hendriks, J.C., van Haaren, M., Beems, T., Zimmerman, C., van Geel, W., de Reus, H., Biert, J., and Verbeek, M.M. (2004). Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. Neurology 62, 1303-1310
24. Rainey, T., Lesko, M., Sacho, R., Lecky, F., and Childs, C. (2009). Predicting outcome after severe traumatic brain injury using the serum S100B biomarker: Results using a single (24h) time-point. Resuscitation 80, 341-345
25. Murillo-Cabezas, F., Mun?oz-Sánchez, M.A., Rincón-Ferrari, M.D., Mart?́n-Rodr?́guez, J.F., Amaya-Villar, R., Garc?́a-Gómez, S., and León-Carrión, J. (2010). The prognostic value of the temporal course of S100 beta protein in post-acute severe brain injury: A prospective and observational study. Brain Inj. 24, 609-619
26. Vos, P.E., Jacobs, B., Andriessen, T.M., Lamers, K.J., Borm, G.F., Beems, T., Edwards, M., Rosmalen, C.F., and Vissers, J.L. (2010). GFAP and S100B are biomarkers of traumatic brain injury: An observational cohort study. Neurology 75, 1786-1793
27. Rodr?́guez-Rodr?́guez, A., Egea-Guerrero, J.J., León-Justel, A., Gordillo-Escobar, E., Revuelto-Rey, J., Vilches-Arenas, A., Carrillo- Vico, A., Dom?́nguez-Roldán, J.M., Murillo-Cabezas, F., and Guerrero, J.M. (2012). Role of S100B protein in urine and serum as an early predictor of mortality after severe traumatic brain injury in adults. Clin. Chim. Acta. 414, 228-233
28. Marshall, L.F., Marshall, S.B., and Klauber, M.R. (1991). A new classification of head injury based on computerized tomography. J. Neurosurg. 75, S14-20
29. Mar?́n-Caballos, A.J., Murillo-Cabezas, F., Dom?́nguez- Roldan, J.M., Leal-Noval, S.R., Rincón-Ferrari, M.D., and Mun?oz-Sánchez, M.A. (2008). Monitoring of tissue oxygen pressure (PtiO2) in cerebral hypoxia: Diagnostic and therapeutic approach. Med. Intensiva 32, 81-90
30. The Brain Trauma Foundation, The American Association of Neurological Surgeons, and The Joint Section on Neurotrauma and Critical Care (2007). Guidelines for the Management of Severe Traumatic Brain Injury. 3rd edition. J. Neurotrauma. 24, S1-S106
31. Wijdicks, E.F. (2001). The diagnosis of brain death. N. Engl. J. Med. 344, 1215-1221
32. Escudero, D. (2009). Brain death diagnosis. Med. Intensiva 33, 185-195
33. Egea-Guerrero, J.J., Revuelto-Rey, J., and Gordillo-Escobar, E. (2012). Cerebral death is not a synonym of whole brain death. Neurologia 27, 377-378
34. Dominguez-Roldán, J.M., Murillo-Cabezas, F., Mun?oz-Sanchez, M.A., Santamar?́a, J.L., Maestre, A., and Rivera, V. (1994). Transcranial doppler sonography: A useful method for the diagnosis of cerebral circulatory arrest in brain dead patients. Revista Espan?ola de Trasplantes 3, 30-35
35. Dom?́nguez-Roldán, J.M., Egea-Guerrero, J.J., Garc?́a-Alfaro, C., Jimenez-Gonzalez, P., Hernandez Hazan?as, F., and Murillo-Cabezas, F. (2010). Transcranial Doppler sonography for the diagnosis of brain death: Analysis of the inter-examiner reliability of detecting cerebral circulatory arrest. Intensive Care Med. 36, Suppl. 2, 205-325
36. Egea-Guerrero, J.J., Revuelto-Rey, J., Latronico, N., Rasulo, F.A, and Wijdicks, E.F. (2011). The case against confirmatory tests for determining brain death in adults. Neurology 76, 489
37. The American Electroencephalographic Society (1994). Guideline three: Minimum technical standards for EEG recording in suspected cerebral death. J. Clin. Neurophysiol. 11, 10-13
38. Petzold, A., Green, A.J., Keir, G., Fairley, S., Kitchen, N., Smith, M., and Thompson, E.J. (2002). Role of serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: A pilot study. Crit. Care Med. 30, 2705-2710
39. Bo?hmer, A.E., Oses, J.P., Schmidt, A.P., Perón, C.S., Krebs, C.L., Oppitz, P.P., D?Avila, T.T., Souza, D.O., Portela, L.V., and Stefani, M.A. (2011). Neuron-specific enolase, S100B, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury. Neurosurgery 68, 1624-1630
40. Siminoff, L.A., Gordon, N., Hewlett, J., and Arnold, R.M. (2011). Factors influencing families? consent for donation of solid organs for transplantation. JAMA 1, 71-77
41. Dom?́nguez-Roldán, J.M., Garc?́a-Alfaro, C., Jimenéz-González, P.I., Hernández-Hazan?as, F., Gascón-Castillo, M.L., and Egea-Guerrero, J.J. (2009). Brain death: Repercussion on the organs and tissues. Med. Intensiva 33, 434-441
42. van Der Hoeven, J.A., Ter Horst, G.J., Molema, G., de Vos, P., Girbes, A.R., Postema, F., Freund, R.L., Wiersema, J., van Schilfgaarde, R., and Ploeg, R.J. (2000). Effects of brain death and hemodynamic status on function and immunologic activation of the potential donor liver in the rat. Ann. Surg. 232, 4-13
43. Wilhelm, M.J., Pratschke, J., Beato, F., Taal, M., Kusaka, M., Hancock, W.W., and Tilney, N.L. (2000). Activation of the heart by donor brain death accelerates acute rejection after transplantation. Circulation 102, 2426-2433
44. Koudstaal, L.G., Hart, N.A., Ottens, P.J., van den Berg, A., Ploeg, R.J., van Goor, H., and Leuvenink, H.G. (2008). Brain death induces inflammation in the donor intestine. Transplantation 86,148-154
45. Nijboer, W.N., Schuurs, T.A., van der Hoeven, J.A., Fekken, S., Wiersema-Buist, J., Leuvenink, H.G., Hofker, S., Homan van der Heide, J.J., van Son, W.J., and Ploeg, R.J. (2004). Effect of brain death on gene expression and tissue activation in human donor kidneys. Transplantation 78, 978-986
46. lznerowicz, A., Chudoba, P., Kamińska, D., Kościelska- Kasprzak, K., Drulis-Fajdasz, D., Ha1oń, A., Janczak, D., Boratyńska, M., Klinger, M., Patrza1ek, D., and Polak, W.G. (2011). Duration of brain death and cold ischemia time, but not warm ischemia time, increases expression of genes associated with apoptosis in transplanted kidneys from deceased donors. Transplant. Proc. 43, 2887-2890
47. Korfias, S., Stranjalis, G., Psachoulia, C., Vasiliadis, C., Pitaridis, M., Boviatsis, E., and Sakas, D.E. (2006). Slight and short-lasting increase of serum S-100B protein in extra-cranial trauma. Brain Inj. 20, 867-872
48. Savola, O., Pyhtinen, J., Leino, T.K., Siitonen, S., Niemela, O., and Hillbom, M. (2004). Effects of head and extracranial injuries on serum protein S100B levels in trauma patients. J. Trauma 56, 1229-1234
49. da Rocha, A.B., Schneider, R.F., de Freitas, G.R., André, C., Grivicich, I., Zanoni, C., Fossá, A., Gehrke, J.T., Pereira, J.G., Kaufmann, M., Simon, D., and Regner, A. (2006). Role of serum S100B as a predictive marker of fatal outcome following isolated severe head injury or multitrauma in males. Clin. Chem. Lab. Med. 44, 1234-1242