A rapid and highly specific method to evaluate the presence of pyrrolizidine alkaloids in Borago officinalis seed oil

Journal of Mass Spectrometry

Volumn 48, Issue 10, 2013, Pages 1078-1082

  Vacillotto, Giulio ^a   Favretto, Donata ^b   Seraglia, Roberta ^a   Pagiotti, Rita ^c   Traldi, Pietro ^a   Mattoli, Luisa ^d  

^a CNR   (Italy)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

^d Research Area   (Italy)

Author keywords

Borago officinalis seed oil; electrospray ionization; high resolution mass spectrometry; Pyrrolizidine alkaloids; tandem mass spectrometry

Indexed keywords

COMPLEX MOLECULES; HIGH RESOLUTION MASS SPECTROMETRY; INTERNATIONAL REGULATIONS; LIMIT OF DETECTION; POSITIVE ION MODE; PYRROLIZIDINE ALKALOID; SEED OIL; TANDEM MASS SPECTROMETRY;

ALKALOIDS; ELECTROSPRAY IONIZATION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; NITROGEN COMPOUNDS; PLANT EXTRACTS;

OILS AND FATS;

BORAGE OIL; PYRROLIZIDINE ALKALOID;

ARTICLE; BORAGO; CONTROLLED STUDY; ELECTROSPRAY; EXTRACTION; FOOD INDUSTRY; GAS CHROMATOGRAPHY; HEALTH FOOD; LIMIT OF DETECTION; MASS SPECTROMETRY; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY;

BORAGO OFFICINALIS SEED OIL; ELECTROSPRAY IONIZATION; HIGH RESOLUTION MASS SPECTROMETRY; PYRROLIZIDINE ALKALOIDS; TANDEM MASS SPECTROMETRY;

BORAGO; LIMIT OF DETECTION; PLANT OILS; PYRROLIZIDINE ALKALOIDS; SEEDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84885600373     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3251     Document Type: Article

References (26)

1. T. Hartmann, C. Theuring, T. Beuerle, L. Ernst, M.S. Singer, E.A. Bernays,. Acquired and partially de novo synthesized pyrrolidine alkaloids in two polyphagusarctiis and the alkaloid profiles of their larval food-plant. J. Chem. Ecol. 2004, 30, 229.
2. D.M. Holstege, J.N. Seiber, F.D. Galey,. Rapid multiresidue screen for alkaloids in plant material and biological sample. J. Agricul. Food Chem. 1995, 43, 691.
3. L.J. Doorduin, K. Vrieling,. A review of the phytochemical support for shifting defence hypothesis. Phytochem. Rev. 2011, 10, 99.
4. M. Màčel, K. Vrielin,. Pyrrolizidine alkaloids as oviposition stimulants for the cinnabar moth, Tyriajacobaeae. J. Chem. Ecol. 2003, 29, 1435.
5. E.A. Bernays, T. Hartmann, R.F. Chapman,. Gustatory responsiveness to pyrrolizidine alkaloids in the Senecio specialist, Tyriajacobaeae (Lepidoptera, Actiidae). Phys. Entomol. 2004, 29, 67.
6. D. Oder, T. Hartmann,. Homospermidine synthase, the first pathway-specific enzyme of pyrrolidine alkaloid biosynthesis, evolved from deoxyhypusine synthase. Proc. Nat. Acad.Sci. 1999, 96, 14777.
7. J. Wainwright, M.M. Schonland,. Toxic hepatitis in black patients in Natal. South AfricanMed. J. 1977, 51, 571.
8. R.J. Huxtable, R.A. Cooper,. in Natural and Selected Synthetic Toxins: Biological Implications, (Eds:, A.T. Tu, W. Gaffield,), American Chemical Society, Washington D.C. 2000, pp: 100-117.
9. F.C Willmot, G.W. Robertson,. Senecio disease or cirrhosis of the liver due to Senecio poisoning. Lancet, 1920, 2, 848.
10. K.A. Beales, K. Betteridge, S.M. Colegate, J.A. Edgar,. Solid-phase extraction and LC-MS analysis of pyrrolizidine alkaloids in honeys. J.Agricul. Food Chem., 2004, 52, 6664.
11. K. Betteridge, Y. Cao, S.M. Colegate,. Improved method for extraction and LC-MS analysis of pyrrolizidine alkaloids and their N-oxides in honey: Application to Echiumvulgare honeys. J. Agricul. Food Chem., 2005, 53, 1894.
12. A. Dübecke, G. Beckh, C. Lüllmann,. Pyrrolizidine Alkaloids in honey and pollen. Food Additives and Contaminants, 2011, 28, 348.
13. M. Kempf, S. Heil, I. Hasslauer, L. Schmidt, K. von der Ohe, C. Theuring, A. Reinhard, P. Schreier, T. Beuerle,. Pyrrolizidine alkaloids in pollen and pollen products. Mol. Nut. FoodChem., 2010, 54, 292.
14. J.A. Edgar, L.W. Smith,. in Natural and Selected Synthetic Toxins: Biological Implications.Transfer of pyrrolizidine alkaloids into eggs: Food safety implications. (Eds:, A.T. Tu, W. Gaffield,) ACS Symposium Series, 1999, 745, 118.
15. E. Röder, Medicinal plants in Europe containing pyrrolizidine alkaloids, Pharmazie, 1995, 50, 83.
16. Y-C. Yang, J. Yan, D. R. Doerge, P-C. Chan, P. P. Fu, M. W. Chou,. Metabolic Activation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine, Leading to DNA Adduct Formation in Vivo. Chem. Res. Toxicol., 2001, 14, 101.
17. E. Roeder,. Medicinal plants in China containing pyrrolizidine alkaloids. Pharmazie, 2000, 55, 711.
18. C.D. Dodson, F.R. Stermitz,. Pyrrolizidine Alkaloids from Borage (Borago officinalis) Seeds and Flowers. J. Nat. Prod., 1986, 49, 727.
19. K.M. Larson, M.R. Roby, F.R. Stermitz,. Unsatured pyrrolizidines from borage (Borago officinalis L.), a common garden herb. J. Nat. Prod., 1984, 47, 747.
20. A.R. Mattocks,. Chemistry and toxicology of pyrrolizidine alkaloids, Academic Press, New York, 1986, pp 1-39.
21. N.A. Beauboire, J.E. Simon,. Production potential of borage (Borago officinalis L.). Acta Hort., 1987, 208, 101.
22. J.A. Duke,. In Handbook of phytochemical constituents of GRAS herbs and other economical plants. CRC Press, London, 1992, p 412
23. I. Wretensiö, L. Svensson, W.W. Christie,. Gas-Chromatography- mass spectrometry Identification of the fatty acids in Borage oil using the picolinyl ester derivatives J. Chromatogr. 1990, 521, 89.
24. H-J. Mierendorff,. Bestimmung von pirrolizidinalkaloidendurchDünn schichtchromatografie in Samenölen von Borago officinalis L.Fta Sci. Technol. 1995, 97, 33.
25. O. Parvais, B. Vander Stricht, R. Vanhaelen-Fastre, M. Vanhaelen,. TLC detection of pyrrolizidine alkaloids in oil extracted from the seeds of Borago officinalis. J. Planar Chromatogr. 1994, 7, 80.
26. 2 of the pyrrolizidine alkaloid adonifoline in Senecio scadens. Phytochem. Anal 2008, 19, 25.