Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model

Oncogene

Volumn 32, Issue 41, 2013, Pages 4989-4994

  Berger, T ^a   Ueda, T ^a,b   Arpaia, E ^a   Chio, I I C ^a   Shirdel, E A ^a,c   Jurisica, I ^c,d   Hamada, K ^e   You Ten, A ^a   Haight, J ^a   Wakeham, A ^a   Cheung, C C ^f   Mak, T W ^a,d  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e KUMAMOTO UNIVERSITY   (Japan)

^f UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Breast cancer; flotillin 1; metastasis; MMTV PyMT; reggie1 2

Indexed keywords

FLOTILLIN 1; FLOTILLIN 2; VIRUS T ANTIGEN;

AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME 17Q; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; FEMALE; FLOT2 GENE; GENE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; LIPID RAFT; LUNG METASTASIS; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR VOLUME;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COMPARATIVE GENOMIC HYBRIDIZATION; DISEASE MODELS, ANIMAL; FEMALE; GENE SILENCING; HUMANS; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANE PROTEINS; MICE;

ANIMALIA; MOUSE MAMMARY TUMOR VIRUS; MUS; MUS MUSCULUS;

EID: 84885572182     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.499     Document Type: Article

References (28)

1. Boyle P, Levin B. International Agency for Research on Cancer. World Health Organization. World Cancer Report 2008. International Agency for Research on Cancer; Distributed by WHO Press: Lyon Geneva, 2008, 510pp.
2. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000; 1: 31-39.
3. Le Moyec L, Tatoud R, Eugene M, Gauville C, Primot I, Charlemagne D et al. Cell and membrane lipid analysis by proton magnetic resonance spectroscopy in five breast cancer cell lines. Br J Cancer 1992; 66: 623-628.
4. Nohara K, Wang F, Spiegel S. Glycosphingolipid composition of MDA-MB-231 and MCF-7 human breast cancer cell lines. Breast Cancer Res Treat 1998; 48: 149-157. (Pubitemid 28156359)
5. Rothberg KG, Heuser JE, Donzell WC, Ying YS, Glenney JR, Anderson RG. Caveolin, a protein component of caveolae membrane coats. Cell 1992; 68: 673-682.
6. Yamada E. The fine structure of the renal glomerulus of the mouse. J Biophys Biochem Cytol 1955; 1: 551-566.
7. Schulte T, Paschke KA, Laessing U, Lottspeich F, Stuermer CA. Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration. Development 1997; 124: 577-587. (Pubitemid 27101691)
8. Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem 1997; 272: 13793-13802. (Pubitemid 27225457)
9. Neumann-Giesen C, Fernow I, Amaddii M, Tikkanen R. Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton. J Cell Sci 2007; 120(Pt 3): 395-406. (Pubitemid 46332503)
10. Stuermer CA, Langhorst MF, Wiechers MF, Legler DF, Von Hanwehr SH, Guse AH et al. PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction. FASEB J 2004; 18: 1731-1733. (Pubitemid 39561666)
11. de Laurentiis A, Donovan L, Arcaro A. Lipid rafts and caveolae in signaling by growth factor receptors. Open Biochem J 2007; 1: 12-32.
12. Pike LJ. Lipid rafts: bringing order to chaos. J Lipid Res 2003; 44: 655-667. (Pubitemid 37279667)
13. Buccione R, Caldieri G, Ayala I. Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix. Cancer Metastasis Rev 2009; 28: 137-149.
14. Yamaguchi H, Takeo Y, Yoshida S, Kouchi Z, Nakamura Y, Fukami K. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res 2009; 69: 8594-8602.
15. Lin C, Wu Z, Lin X, Yu C, Shi T, Zeng Y et al. Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clin Cancer Res 2011; 17: 3089-3099.
16. Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D et al. Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. Cancer Res 2004; 64: 7361-7369. (Pubitemid 39372075)
17. Rickman DS, Millon R, De Reynies A, Thomas E, Wasylyk C, Muller D et al. Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays. Oncogene 2008; 27: 6607-6622.
18. Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 1992; 12: 954-961.
19. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA et al. TM4 microarray software suite. Methods Enzymol 2006; 411: 134-193.
20. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N et al. TM4: a free, open-source system for microarray data management and analysis. BioTechniques 2003; 34: 374-378. (Pubitemid 36184095)
21. Ludwig A, Otto GP, Riento K, Hams E, Fallon PG, Nichols BJ. Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J Cell Biol 2010; 191: 771-781.
22. Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ et al. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003; 163: 2113-2126. (Pubitemid 37310040)
23. Qiu TH, Chandramouli GV, Hunter KW, Alkharouf NW, Green JE, Liu ET. Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease. Cancer Res 2004; 64: 5973-5981. (Pubitemid 39129393)
24. Maglione JE, Moghanaki D, Young LJ, Manner CK, Ellies LG, Joseph SO et al. Transgenic polyoma middle-T mice model premalignant mammary disease. Cancer Res 2001; 61: 8298-8305. (Pubitemid 33091625)
25. de Leeuw RJ, Davies JJ, Rosenwald A, Bebb G, Gascoyne RD, Dyer MJ et al. Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes. Hum Mol Genet 2004; 13: 1827-1837. (Pubitemid 39214331)
26. Ishkanian AS, Malloff CA, Watson SK, DeLeeuw RJ, Chi B, Coe BP et al. A tiling resolution DNA microarray with complete coverage of the human genome. Nat Genet 2004; 36: 299-303. (Pubitemid 38282757)
27. Watson SK, deLeeuw RJ, Ishkanian AS, Malloff CA, Lam WL. Methods for high throughput validation of amplified fragment pools of BAC DNA for constructing high resolution CGH arrays. BMC Genomics 2004; 5: 6.
28. Arpaia E, Blaser H, Quintela-Fandino M, Duncan G, Leong HS, Ablack A et al. The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene 2012; 31: 884-896.