The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Ziółkowska Suchanek, Iwona ^a   Mosor, Maria ^a   Wierzbicka, Małgorzata ^b   Rydzanicz, Małgorzata ^a   Baranowska, Marta ^a   Nowak, Jerzy ^a  

^a INSTITUTE OF HUMAN GENETICS   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Cancer susceptibility; DNA repair genes; Laryngeal cancer; Multiple primary tumors of head and neck

Indexed keywords

MRE11 PROTEIN; RAD50 PROTEIN;

ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEAD AND NECK CANCER; HUMAN; MAJOR CLINICAL STUDY;

CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; LARYNGEAL NEOPLASMS; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84885465717     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-113     Document Type: Article

References (18)

1. Cianfriglia F, Di Gregorio DA, Manieri A. Multiple primary tumours in patients with oral squamous cell carcinoma. Oral Oncol 1999, 35:157-163. 10.1016/S1368-8375(98)00105-5, 10435150.
2. Warren S, Gates O. Multiple primary malignant tumors: survey of the literature and statistical study. Am J Cancer 1932, 16:1358.
3. Williams GJ, Lees-Miller SP, Tainer JA. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst) 2010, 9:1299-1306.
4. Mosor M, Ziółkowska I, Pernak-Schwarz M, Januszkiewicz-Lewandowska D, Nowak J. Association of the heterozygous germline I171V mutation of the NBS1 gene with childhood acute lymphoblastic leukemia. Leukemia 2006, 20:1454-1456. 10.1038/sj.leu.2404285, 16810201.
5. Dzikiewicz-Krawczyk A. The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. Mutat Res. 2008, 659:262-273. 10.1016/j.mrrev.2008.05.005, 18606567.
6. Heikkinen K, Karppinen SM, Soini Y, Makinen M, Winqvist R. Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. J of med genet 2003, 40:131.
7. Heikkinen K, Rapakko K, Karppinen SM, Erkko H, Knuutila S, Lundán T, Mannermaa A, Børresen-Dale AL, Borg A, Barkardottir RB, Petrini J, Winqvist R. RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. Carcinogenesis 2006, 27:1593-1599. 3006189, 16474176.
8. Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, Aittomäki K, Blomqvist C, Heikkilä P, Lukas J, Nevanlinna H, Bartek J. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol Oncol. 2008, 2:296-316. 10.1016/j.molonc.2008.09.007, 19383352.
9. Ziółkowska I, Mosor M, Wierzbicka M, Rydzanicz M, Pernak-Schwarz M, Nowak J. Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene. Cancer Sci 2007, 98:1701-1705. 10.1111/j.1349-7006.2007.00594.x, 17894553.
10. Ziółkowska-Suchanek I, Mosor M, Wierzbicka M, Fichna M, Rydzanicz M, Nowak J. Association of polymorphisms and haplotypes of the NBN gene with laryngeal cancer and multiple primary tumors of the head and neck. Head Neck 2012, 34:376-383. 10.1002/hed.21741, 21472885.
11. Mosor M, Ziółkowska-Suchanek I, Roznowski K, Baranowska M, Januszkiewicz-Lewandowska D, Nowak J. RAD50 gene mutations are not likely a risk factor for breast cancer in Poland. Breast Cancer Res Treat 2010, 123:607-609. 10.1007/s10549-010-0992-y, 20571869.
12. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B 1995, 57:289-300.
13. Tommiska J, Seal S, Renwick A, Barfoot R, Baskcomb L, Jayatilake H, Bartkova J, Tallila J, Kaare M, Tamminen A, Heikkilä P, Evans DG, Eccles D, Aittomäki K, Blomqvist C, Bartek J, Stratton MR, Nevanlinna H, Rahman N. Evaluation of RAD50 in familial breast cancer predisposition. Int J Cancer 2006, 118:2911-2916. 10.1002/ijc.21738, 16385572.
14. Uhrhammer N, Delort L, Bignon YJ. Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population. Cancer Epidemiol Biomarkers Prev 2009, 18:684-685. 10.1158/1055-9965.EPI-08-0971, 19190165.
15. Schuetz JM, MaCarthur AC, Leach S, Lai AS, Gallagher RP, Connors JM, Gascoyne RD, Spinelli JJ, Brooks-Wilson AR. Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma. BMC Med Genet 2009, 16:117.
16. Hsu HM, Wang HC, Chen ST, Hsu GC, Shen CY, Yu JC. Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Cancer Epidemiol Biomarkers Prev 2007, 16:2024-2032. 10.1158/1055-9965.EPI-07-0116, 17932350.
17. Choudhury A, Elliott F, Iles MM, Churchman M, Bristow RG, Bishop DT, Kiltie AE. Analysis of variants in DNA damage signalling genes in bladder cancer. BMC Med Genet 2008, 9:69. 2488326, 18638378.
18. Mosor M, Ziółkowska-Suchanek I, Nowicka K, Dzikiewicz-Krawczyk A, Januszkiewicz-Lewandowska D, Nowak J. Germline mutations in MRE11/RAD50/NBN complex genes in childhood leukemia. BMC Cancer 2013, in press.