Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

Journal of Experimental Medicine

Volumn 210, Issue 10, 2013, Pages 1937-1945

  Soler, Adriana ^a   Serra, Helena ^a   Pearce, Wayne ^b   Angulo, Ana ^a   Guillermet Guibert, Julie ^b   Friedman, Lori S ^c   Viñals, Francesc ^a   Gerhardt, Holger ^d   Casanovas, Oriol ^a   Graupera, Mariona ^a   Vanhaesebroeck, Bart ^b  

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c GENENTECH INC   (United States)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HYPOXIA; MALE; MOUSE; NECROSIS; NONHUMAN; PERICYTE; PRIORITY JOURNAL; STROMA; TUMOR GROWTH; VASCULARIZATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANOMA, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; STROMAL CELLS;

EID: 84885440456     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20121571     Document Type: Article

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