Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15nm in diameter does not induce mesothelial carcinogenesis in rats

Pathology International

Volumn 63, Issue 9, 2013, Pages 457-462

  Nagai, Hirotaka ^a   Okazaki, Yasumasa ^a   Chew, Shan Hwu ^a   Misawa, Nobuaki ^a   Miyata, Yasumitsu ^b   Shinohara, Hisanori ^b   Toyokuni, Shinya ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Environmental health; Malignant mesothelioma; Multiwalled carbon nanotube

Indexed keywords

MULTI WALLED NANOTUBE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; DIAMETER; LENGTH; MALE; MEASUREMENT; MESOTHELIOMA; NONHUMAN; PRIORITY JOURNAL; RIGIDITY; SURFACE PROPERTY;

ENVIRONMENTAL HEALTH; MALIGNANT MESOTHELIOMA; MULTIWALLED CARBON NANOTUBE;

ANIMALS; ASBESTOS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; ENVIRONMENTAL HEALTH; FEMALE; INJECTIONS, INTRAPERITONEAL; MALE; MESOTHELIOMA; NANOTUBES, CARBON; RATS; RATS, INBRED F344;

EID: 84885438020     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12093     Document Type: Article

References (18)

1. Thayer AM. Carbon nanotubes by the metric ton. Chem Eng News 2007; 85: 29-35.
2. Kostarelos K, Bianco A, Prato M. Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol 2009; 4: 627-633.
3. Nagai H, Toyokuni S. Biopersistent fiber-induced inflammation and carcinogenesis: Lessons learned from asbestos toward safety of fibrous nanomaterials. Arch Biochem Biophys 2010; 502: 1-7.
4. Kostarelos K. The long and short of carbon nanotube toxicity. Nat Biotechnol 2008; 26: 774-776.
5. Donaldson K, Poland CA. Nanotoxicology: New insights into nanotubes. Nat Nanotechnol 2009; 4: 708-710.
6. Toyokuni S. Genotoxicity and carcinogenicity risk of carbon nanotubes. Adv Drug Deliv Rev 2013; doi:pii: S0169-409X(13)00149-X.10.1016/j.addr.2013.05.011. (in press)
7. Donaldson K, Murphy FA, Duffin R, Poland CA. Asbestos, carbon nanotubes and the pleural mesothelium: A review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 2010; 7: 5.
8. Takagi A, Hirose A, Nishimura T etal. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 2008; 33: 105-116.
9. Sakamoto Y, Nakae D, Fukumori N etal. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci 2009; 34: 65-76.
10. Muller J, Delos M, Panin N, Rabolli V, Huaux F, Lison D. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol Sci 2009; 110: 442-448.
11. Nagai H, Toyokuni S. Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis: Shedding light on fiber entry mechanism. Cancer Sci 2012; 103: 1378-1390.
12. Nagai H, Okazaki Y, Chew SH etal. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci U S A 2011; 108: E1330-1338.
13. Jiang L, Akatsuka S, Nagai H etal. Iron overload signature in chrysotile-induced malignant mesothelioma. J Pathol 2012; 228: 366-377.
14. Hu Q, Akatsuka S, Yamashita Y etal. Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Lab Invest 2010; 90: 360-373.
15. Donaldson K, Poland CA. Inhaled nanoparticles and lung cancer-what we can learn from conventional particle toxicology. Swiss Med Wkly 2012; 142: w13547.
16. Lipman RD, Chrisp CE, Hazzard DG, Bronson RT. Pathologic characterization of brown Norway, brown Norway x Fischer 344, and Fischer 344 x brown Norway rats with relation to age. J Gerontol A Biol Sci Med Sci 1996; 51: B54-59.
17. Toyokuni S. Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci 2009; 71: 1-10.
18. Shvedova AA, Pietroiusti A, Fadeel B, Kagan VE. Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress. Toxicol Appl Pharmacol 2012; 261: 121-133.