Overexpression of response gene to complement 32 (RGC32) promotes cell invasion and induces epithelial-mesenchymal transition in lung cancer cells via the NF-κB signaling pathway

Tumor Biology

Volumn 34, Issue 5, 2013, Pages 2995-3002

  Sun, Qinying ^a   Yao, Xiaopeng ^a   Ning, Yunye ^a   Zhang, Wei ^a   Zhou, Guowu ^a   Dong, Yuchao ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition; Invasion; Lung cancer; Migration; Nuclear factor B; Response gene to complement 32

Indexed keywords

EID: 84885433590     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0864-2     Document Type: Article

References (21)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90. doi: 10.3322/caac.20107.
2. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24(14):2137-50. doi: 10.1200/JCO.2005.05.2308.
3. Ulahannan SV, Brahmer JR. Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer. Cancer Invest. 2011;29(4):325-37. doi: 10.3109/07357907.2011.554476.
4. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139(5):871-90. doi: 10.1016/j.cell.2009.11.007.
5. Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009;119(6):1429-37. doi: 10.1172/JCI36183.
6. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell. 2006;127(4):679-95. doi: 10.1016/j.cell.2006.11.001.
7. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2(6):442-54. doi: 10.1038/nrc822.
8. Badea TC, Niculescu FI, Soane L, Shin ML, Rus H. Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes. J Biol Chem. 1998;273(41):26977-81.
9. Badea T, Niculescu F, Soane L, Fosbrink M, Sorana H, Rus V, et al. RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase. J Biol Chem. 2002;277(1):502-8. doi: 10.1074/jbc.M109354200.
10. Fosbrink M, Cudrici C, Niculescu F, Badea TC, David S, Shamsuddin A, et al. Overexpression of RGC-32 in colon cancer and other tumors. Exp Mol Pathol. 2005;78(2):116-22. doi: 10.1016/j.yexmp.2004.11.001.
11. Kim DS, Lee JY, Lee SM, Choi JE, Cho S, Park JY. Promoter methylation of the RGC32 gene in nonsmall cell lung cancer. Cancer. 2011;117(3):590-6. doi: 10.1002/cncr.25451.
12. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402-8. doi: 10.1006/meth.2001.1262.
13. Lorenzl S, Albers DS, Narr S, Chirichigno J, Beal MF. Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease. Exp Neurol. 2002;178(1):13-20.
14. Heissig B, Hattori K, Friedrich M, Rafii S, Werb Z. Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases. Curr Opin Hematol. 2003;10(2):136-41.
15. Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol. 2006;172(7):973-81. doi: 10.1083/jcb.200601018.
16. Vlaicu SI, Cudrici C, Ito T, Fosbrink M, Tegla CA, Rus V, et al. Role of response gene to complement 32 in diseases. Arch Immunol Ther Exp (Warsz). 2008;56(2):115-22. doi: 10.1007/s00005-008-0016-3.
17. Zhu L, Qin H, Li PY, Xu SN, Pang HF, Zhao HZ, et al. Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor beta-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3. J Exp Clin Cancer Res. 2012;31:29. doi: 10.1186/1756-9966-31- 29.
18. Thompson EW, Newgreen DF, Tarin D. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res. 2005;65(14):5991-5. doi: 10.1158/0008-5472.CAN-05-0616. discussion 5.
19. Cardiff RD. Epithelial to mesenchymal transition tumors: fallacious or snail's pace? Clin Cancer Res. 2005;11(24 Pt 1):8534-7. doi: 10.1158/1078-0432.CCR-05-2250.
20. Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY. RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem. 2009;284(14):9426-32. doi: 10.1074/jbc.M900039200.
21. Guo X, Jose PA, Chen SY. Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells. Am J Physiol Cell Physiol. 2011;300(6):C1415-21. doi: 10.1152/ajpcell.00204. 2010.