Is Alzheimer's disease a homogeneous disease entity?

Journal of Neural Transmission

Volumn 120, Issue 10, 2013, Pages 1475-1477

  Korczyn, Amos D ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Alzheimer's disease; Dementia; Pathogenesis; Risk factors

Indexed keywords

BIOLOGICAL MARKER;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; BRAIN DISEASE; DEMENTIA; DOWN SYNDROME; GENE MUTATION; GERIATRIC PATIENT; HUMAN; LIVER CIRRHOSIS; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; RISK FACTOR; SENILE DEMENTIA; SENILE PLAQUE;

ALZHEIMER DISEASE; HUMANS;

EID: 84885432016     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-013-1060-7     Document Type: Article

References (18)

1. American Psychiatric Association. Fourth edition text revision DSM-IV-TR (2000) Diagnostic and statistical manual of mental disorders. APA, Washington
2. Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C (2011) Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther 3:1
3. Davis DG, Schmitt FA, Wekstein DR, Markesbery WR (1999) Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol 58:376-388
4. Engelborghs S, Le Bastard N (2012) The role of CSF biomarkers in the diagnostic work-up of mixed vascular-degenerative dementia. J Neurol Sci 322:197-199
5. Gatson JW, Warren V, Abdelfattah K, Wolf S, Hynan LS, Moore C, Diaz-Arrastia R, Minei JP, Madden C, Wigginton JG (2013) Detection of β-amyloid oligomers as a predictor of neurological outcome after brain injury. J Neurosurg. doi: 10.3171/2013.2.JNS121771
6. Huang KL, Lin KJ, Ho MY, Chang YJ, Chang CH, Wey SP, Hsieh CJ, Yen TC, Hsiao IT, Lee TH (2012) Amyloid deposition after cerebral hypoperfusion: evidenced on [(18)F] AV-45 positron emission tomography. J Neurol Sci 319:124-129
7. Korczyn AD (2002) Mixed dementia - the most common cause of dementia. Ann NY Acad Sci 977:129-134
8. Korczyn AD (2008) The amyloid cascade hypothesis. Alzheimers Dement 4:176-178
9. Korczyn AD, Vakhapova V, Grinberg LT (2012) Vascular dementia. J Neurol Sci 322:2-10
10. Lin B (2013) Encephalopathy: a vicious cascade following forebrain ischemia and hypoxia. Cent Nerv Syst Agents Med Chem 13:57-70
11. Mandel S, Korczyn AD (2013) The Use of Biomarkers for Prediction and Prevention of Alzheimer's and Parkinson's Diseases. In: Golubnitschaja O (ed) Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future
12. Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ (2010) Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 330:1774
13. Niedowicz DM, Beckett TL, Matveev S, Weidner AM, Baig I, Kryscio RJ, Mendiondo MS, LeVine H 3rd, Keller JN, Murphy MP (2012) Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease. Ann Neurol 72:564-570
14. Robakis NK (2010) Are Abeta and its derivatives causative agents or innocent bystanders in AD? Neurodegener Dis 7:32-37
15. Robakis NK (2013) Cell Signaling Abnormalities May Drive Neurodegeneration in Familial Alzheimer Disease. Neurochem Res
16. Sperling R, Johnson K (2010) Pro: can biomarkers be gold standards in Alzheimer's disease? Alzheimer's Res Ther 2:17
17. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. Neurobiol Aging 18(4 Suppl):S1-S2
18. Wang BW, Lu E, Mackenzie IR, Assaly M, Jacova C, Lee PE, Beattie BL, Hsiung GY (2012) Multiple pathologies are common in Alzheimer patients in clinical trials. Can J Neurol Sci 39:592-599