Pharmacokinetic/pharmacodynamic assessment of the effects of parenteral administration of a fluoroquinolone on the intestinal microbiota: Comparison of bactericidal activity at the gut versus the systemic level in a pig model

International Journal of Antimicrobial Agents

Volumn 42, Issue 5, 2013, Pages 429-435

  Ferran, Aude A ^a   Bibbal, Delphine ^a   Pellet, Terence ^b   Laurentie, Michel ^b   Gicquel Bruneau, Mireille ^b   Sanders, Pascal ^b   Schneider, Marc ^c   Toutain, Pierre Louis ^a   Bousquet Melou, Alain ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b FRENCH AGENCY FOR FOOD   (France)

^c Vétoquinol Research and Development Center   (France)

Author keywords

Bactericidal activity; Commensal microbiota; Fluoroquinolone; Inoculum size; Marbofloxacin

Indexed keywords

MARBOFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIGESTIVE SYSTEM; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EXPOSURE; ESCHERICHIA COLI; IN VITRO STUDY; INTESTINE FLORA; LUNG; MALE; NONHUMAN; PASTEURELLA MULTOCIDA; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; SMALL INTESTINE; SWINE;

BACTERICIDAL ACTIVITY; COMMENSAL MICROBIOTA; FLUOROQUINOLONE; INOCULUM SIZE; MARBOFLOXACIN;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; FLUOROQUINOLONES; GASTROINTESTINAL TRACT; INJECTIONS, INTRAMUSCULAR; INTESTINES; LUNG; PLASMA; SWINE;

EID: 84885425150     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.07.008     Document Type: Article

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