A model of persistent learned nonuse following focal ischemia in rats

Neurorehabilitation and Neural Repair

Volumn 27, Issue 9, 2013, Pages 900-907

  Maclellan, Crystal L ^a   Langdon, Kristopher D ^b,c   Botsford, Alex ^b   Butt, Stephanie ^b   Corbett, Dale ^b,c,d,e  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^c HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

animal model; learned nonuse; recovery; rehabilitation; skilled reaching; stroke

Indexed keywords

ENDOTHELIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR THERAPY; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; FOOD; FORELIMB; FUNCTIONAL DISEASE; MALE; MOTOR CORTEX; MOVEMENT THERAPY; NONHUMAN; PERSISTENT LEARNED NONUSE; RAT; REWARD; TASK PERFORMANCE;

ANIMAL MODEL; LEARNED NONUSE; RECOVERY; REHABILITATION; SKILLED REACHING; STROKE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; LEARNING; MALE; MOTOR SKILLS; RATS; RATS, SPRAGUE-DAWLEY; STROKE;

EID: 84885413422     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968313496323     Document Type: Article

References (31)

1. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation. 2012 ; 125: e2 - e220
2. Jorgensen HS, Nakayama H, Raaschou HO, Vive-Larsen J, Stoier M, Olsen TS. Outcome and time course of recovery in stroke. Part I: Outcome. The Copenhagen Stroke Study. Arch Phys Med Rehabil. 1995 ; 76: 399-405
3. Faria-Fortini I, Michaelsen SM, Cassiano JG, Teixeira-Salmela LF. Upper extremity function in stroke subjects: relationships between the international classification of functioning, disability, and health domains. J Hand Ther. 2011 ; 24: 257-264
4. Michielsen ME, Selles RW, Stam HJ, Ribbers GM, Bussmann JB. Quantifying nonuse in chronic stroke patients: a study into paretic, nonparetic, and bimanual upper-limb use in daily life. Arch Phys Med Rehabil. 2012 ; 93: 1975-1981
5. Dobkin BH. Clinical practice: rehabilitation after stroke. N Engl J Med. 2005 ; 352: 1677-1684
6. Taub E, Crago JE, Burgio LD, et al. An operant approach to rehabilitation medicine: overcoming learned nonuse by shaping. J Exp Anal Behav. 1994 ; 61: 281-293
7. Taub E, Uswatte G, Mark VW, Morris DM. The learned nonuse phenomenon: implications for rehabilitation. Eura Medicophys. 2006 ; 42: 241-256
8. Nijland R, Kwakkel G, Bakers J, van Wegen E. Constraint-induced movement therapy for the upper paretic limb in acute or sub-acute stroke: a systematic review. Int J Stroke. 2011 ; 6: 425-433
9. Klein A, Sacrey LA, Whishaw IQ, Dunnett SB. The use of rodent skilled reaching as a translational model for investigating brain damage and disease. Neurosci Biobehav Rev. 2012 ; 36: 1030-1042
10. Whishaw IQ, Pellis SM, Gorny BP. Skilled reaching in rats and humans: evidence for parallel development or homology. Behav Brain Res. 1992 ; 47: 59-70
11. Allred RP, Cappellini CH, Jones TA. The "good" limb makes the "bad" limb worse: experience-dependent interhemispheric disruption of functional outcome after cortical infarcts in rats. Behav Neurosci. 2010 ; 124: 124-132
12. Allred RP, Maldonado MA, Hsu JE, Jones TA. Training the "less-affected" forelimb after unilateral cortical infarcts interferes with functional recovery of the impaired forelimb in rats. Restor Neurol Neurosci. 2005 ; 23: 297-302
13. Allred RP, Jones TA. Maladaptive effects of learning with the less-affected forelimb after focal cortical infarcts in rats. Exp Neurol. 2008 ; 210: 172-181
14. Montoya CP, Campbell-Hope LJ, Pemberton KD, Dunnett SB. The "staircase test": a measure of independent forelimb reaching and grasping abilities in rats. J Neurosci Methods. 1991 ; 36: 219-228
15. MacLellan CL, Keough MB, Granter-Button S, Chernenko GA, Butt S, Corbett D. A critical threshold of rehabilitation involving brain-derived neurotrophic factor is required for poststroke recovery. Neurorehabil Neural Repair. 2011 ; 25: 740-748
16. Biernaskie J, Chernenko G, Corbett D. Efficacy of rehabilitative experience declines with time after focal ischemic brain injury. J Neurosci. 2004 ; 24: 1245-1254
17. Ploughman M, Windle V, Maclellan CL, White N, Dore JJ, Corbett D. Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke. 2009 ; 40: 1490-1495
18. Schallert T, Woodlee MT The Behavior of the Laboratory Rat: A Handbook With Tests. Whishaw I Kolb B, ed. Oxford, UK: Oxford University Press ; 129-140.
19. Windle V, Szymanska A, Granter-Button S, et al. An analysis of four different methods of producing focal cerebral ischemia with endothelin-1 in the rat. Exp Neurol. 2006 ; 201: 324-334
20. Paxinos G, Watson C The Rat Brain in Stereotaxic Coordinates. 4 th ed.San Diego, CA: Academic Press; 1998. San Diego, CA: Academic Press ; 1998 :
21. MacLellan CL, Auriat AM, McGie SC, et al. Gauging recovery after hemorrhagic stroke in rats: implications for cytoprotection studies. J Cereb Blood Flow Metab. 2006 ; 26: 1031-1042
22. Darling WG, Pizzimenti MA, Morecraft RJ. Functional recovery following motor cortex lesions in non-human primates: experimental implications for human stroke patients. J Integr Neurosci. 2011 ; 10: 353-384
23. Huang HC, Chung KC, Lai DC, Sung SF. The impact of timing and dose of rehabilitation delivery on functional recovery of stroke patients. J Chin Med Assoc. 2009 ; 72: 257-264
24. Kwakkel G. Impact of intensity of practice after stroke: issues for consideration. Disabil Rehabil. 2006 ; 28: 823-830
25. Kwakkel G, Kollen BJ, Wagenaar RC. Long term effects of intensity of upper and lower limb training after stroke: a randomised trial. J Neurol Neurosurg Psychiatry. 2002 ; 72: 473-479
26. Jette DU, Warren RL, Wirtalla C. The relation between therapy intensity and outcomes of rehabilitation in skilled nursing facilities. Arch Phys Med Rehabil. 2005 ; 86: 373-379
27. Biernaskie J, Corbett D. Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury. J Neurosci. 2001 ; 21: 5272-5280
28. Erickson CA, Gharbawie OA, Whishaw IQ. Attempt-dependent decrease in skilled reaching characterizes the acute postsurgical period following a forelimb motor cortex lesion: an experimental demonstration of learned nonuse in the rat. Behav Brain Res. 2007 ; 179: 208-218
29. Taub E, Uswatte G, Elbert T. New treatments in neurorehabilitation founded on basic research. Nat Rev Neurosci. 2002 ; 3: 228-236
30. Clarke J, Ploughman M, Corbett D. A qualitative and quantitative analysis of skilled forelimb reaching impairment following intracerebral hemorrhage in rats. Brain Res. 2007 ; 1145: 204-212
31. Biernaskie J, Szymanska A, Windle V, Corbett D. Bi-hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats. Eur J Neurosci. 2005 ; 21: 989-999