Hydrophilic interaction liquid chromatography coupled with MS/MS to detect and quantify dicarboxyethyl glutathione, a metabolic biomarker of the fumarate hydratase deficient cancer cell

Journal of Separation Science

Volumn 36, Issue 20, 2013, Pages 3303-3309

  Nguyen, Hien P ^a   Chandel, Navdeep S ^b   Deberardinis, Ralph J ^a   Schug, Kevin A ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

FH deficient cells; Fumarate hydratase; Glutathione; HILIC MS MS; Matrix effect

Indexed keywords

CELLS; CYTOLOGY; HYDROPHILICITY; ITERATIVE METHODS; PEPTIDES; SULFUR COMPOUNDS;

GLUTATHIONE DISULFIDE; GLUTATHIONES; HILIC-MS/MS; HYDRATASE; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; MATRIX EFFECTS; METABOLIC BIOMARKERS; RELATIVE QUANTITATIONS;

LIQUID CHROMATOGRAPHY;

BIOLOGICAL MARKER; CELL EXTRACT; FUMARATE HYDRATASE; GLUTATHIONE; GLUTATHIONE DISULFIDE;

ARTICLE; CALIBRATION; CANCER CELL; HUMAN; HUMAN CELL; HYDROPHILIC INTERACTION CHROMATOGRAPHY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

FH DEFICIENT CELLS; FUMARATE HYDRATASE; GLUTATHIONE; HILIC-MS/MS; MATRIX EFFECT;

BIOLOGICAL MARKERS; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; FUMARATE HYDRATASE; GLUTATHIONE; HUMANS; MOLECULAR STRUCTURE; TANDEM MASS SPECTROMETRY;

EID: 84885410316     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201300602     Document Type: Article

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