The increasing detection of asymptomatic left ventricular dysfunction in patients with type 2 diabetes mellitus without overt cardiac disease: Data from the SHORTWAVE study

Diabetes Research and Clinical Practice

Volumn 101, Issue 3, 2013, Pages 309-316

  Faden, Giacomo ^a   Faganello, Giorgio ^b   De Feo, Stefania ^c   Berlinghieri, Nicola ^a   Tarantini, Luigi ^d   Di Lenarda, Andrea ^b   Faggiano, Pompilio ^a   Cioffi, Giovanni ^e  

^a Cardiology Unit   (Italy)

^b Cardiovascular Center   (Italy)

^c Pederzolli Hospital   (Italy)

^d SAN MARTINO HOSPITAL   (Italy)

^e Villa Bianca Hospital   (Italy)

Author keywords

Diastolic function; Longitudinal function; Midwall shortening; Systolic function; Type 2 diabetes

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; C REACTIVE PROTEIN; HEMOGLOBIN A1C;

ADULT; AGE; AGED; AORTIC VALVE CALCIFICATION; ARTERY CALCIFICATION; ARTICLE; ASYMPTOMATIC DISEASE; ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTION; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISEASE ASSOCIATION; DOPPLER ECHOCARDIOGRAPHY; EARLY DIAGNOSIS; EARLY DIASTOLIC TISSUE DOPPLER VELOCITY OF MITRAL ANNULUS; EARLY DIASTOLIC VELOCITY OF TRANSMITRAL FLOW; FEMALE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HEART EJECTION FRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; LEFT VENTRICLE STRESS CORRECTED MIDWALL SHORTENING; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PEAK MITRAL ANNULAR SYSTOLIC VELOCITY; PREVALENCE; PROTEIN BLOOD LEVEL; SENSITIVITY ANALYSIS; TISSUE DOPPLER IMAGING;

DIASTOLIC FUNCTION; LONGITUDINAL FUNCTION; MIDWALL SHORTENING; SYSTOLIC FUNCTION; TYPE 2 DIABETES;

AGED; AGED, 80 AND OVER; DIABETES MELLITUS, TYPE 2; ECHOCARDIOGRAPHY; FEMALE; HEART DISEASES; HUMANS; MALE; MIDDLE AGED; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84885375626     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2013.07.004     Document Type: Article

References (48)

1. Clarke P., Gray A., Legood R., Briggs A., Holman R. The impact of diabetes-related complications on health-care costs: results from the UK prospective diabetes study (UKPDS Study no. 65). Diabet Med 2003, 20:442-450.
2. A Joint Editorial Statement by the American Diabetes Association, The National Heart, Lung and Blood Institute, The Juvenile Diabetes Foundation International, The National Institute of Diabetes and Digestive and Kidney Diseases, The American Heart Association Diabetes Mellitus: a major risk factor for cardiovascular disease. Circulation 1999, 100:1132-1133.
3. Boudina S., Abel Ed. Diabetic cardiomyopathy revisited. Circulation 2007, 115:3213-3223.
4. From A.M., Scott G.C., Chen H.H. The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction. J Am Coll Cardiol 2010, 55:300-305.
5. Devereux R.B., Roman M.J., Paranicas M., O'Grady M.J., Lee E.T., Welty T.K., et al. Impact of diabetes on cardiac structure and function. The Strong Heart Study. Circulation 2000, 101:2271-2276.
6. Zarich S.W., Arbuckle B.E., Cohen L.R., Roberts M., Nesto R.W. Diastolic abnormalities in young asymptomatic diabetic patients assessed by pulsed Doppler echocardiography. J Am Coll Cardiol 1988, 12:114-120.
7. Russo C., Sacco R.L., Tullio M.R. Effect of diabetes and hypertension on left ventricular diastolic function in a high-risk population without evidence of heart disease. Eur J Heart Fail 2010, 12:454-461.
8. Fang Z.Y., Yuda S., Anderson V., Short L., Case C., Marwick T.H. Echocardiographic detection of early diabetic myocardial disease. J Am Coll Cardiol 2003, 41:611-617.
9. Cioffi G., Giorda C.B., Chinali M., Di Lenarda A., Faggiano P., Lucci D., et al. Analysis of midwall shortening reveals high prevalence of left ventricular myocardial dysfunction in patients with diabetes mellitus: the DYDA study. Eur J Prev Cardiol 2012, 19(5):935-943.
10. Palmieri V., Bella J.N., Arnett D.K., Liu J.E., Oberman A., Schuck M.Y., et al. Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) study. Circulation 2001, 103:102-107.
11. Ha J.W., Lee H.C., Kang E.S., Ahn C.M., Kim J.M., Ahn J.A., et al. Abnormal left ventricular longitudinal function reserve in patients with diabetes mellitus: implication for detecting subclinical myocardial dysfunction using exercise tissue Doppler echocardiography. Heart 2007, 93:1571-1576.
12. Ernande L., Rietzschel E.R., Bergerot C., De Buyzere M.L., Schnell F., Groisne L., et al. Impaired myocardial radial function in asymptomatic patients with type 2 diabetes mellitus: a speckle-tracking imaging study. J Am Soc Echocardiogr 2010, 23:1266-1272.
13. Andersen N.H., Poulsen S.H., Eiskjaer H., Poulsen P.L., Mogensen C.E. Decreased left ventricular longitudinal contraction in normotensive and normoalbuminuric patients with Type II diabetes mellitus: a Doppler tissue tracking and strain rate echocardiography study. Clin Sci 2003, 105:59-66.
14. Rademakers F.E., Rogers W.J., Guier W.H., Hutchins G.M., Siu C.O., Weistfeldt M.L., et al. Relation of regional cross-fiber shortening to wall thickening in the intact heart. Three-dimensional strain analysis by NMR tagging. Circulation 1994, 89:1174-1182.
15. Devereux R.B., Alonso D.R., Lutas E.M., Gottlieb G.J., Campo E., Sachs I., et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986, 57:450-458.
16. De Simone G., Devereux R.B., Daniels S.R., Koren M.J., Meyer R.A., Laragh J.H. Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol 1995, 25:1056-1062.
17. De Simone G., Daniels S.R., Kimball T.R., Roman M.J., Romano C., Chinali M., et al. Evaluation of concentric left ventricular geometry in humans: evidence for age-related systematic underestimation. Hypertension 2005, 45:64-68.
18. de Simone G., Devereux R.B., Ganau A., Hahn R.T., Saba P.S., Mureddu G.F., et al. Estimation of left ventricular chamber and stroke volume by limited M-mode echocardiography and validation by two-dimensional and Doppler echocardiography. Am J Cardiol 1996, 78:801-807.
19. de Simone G., Devereux R.B., Roman M.J., Ganau A., Saba P.S., Alderman M.H., et al. Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol 1994, 23:1444-1451.
20. Sohn D.W., Chai H.I., Lee D.J., Kim H.C., Kim H.S., Oh B.H., et al. Assessment of mitral annulus velocity by tissue Doppler imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol 1997, 30:474-480.
21. Nagueh S.F., Appleton C.P., Gillebert T.C., Marino P.N., Oh J.K., Smiseth O.A., et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr 2009, 22:107-133.
22. Redfield M.M., Jacobsen S.J., Burnett J.C., Mahoney D.W., Bailey K.R., Rodeheffer R.J. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. J Am Med Assoc 2003, 289:194-202.
23. Nagueh S.F., Middleton K.J., Kopelen H.A. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997, 30:1527-1533.
24. Fox C.S., Vasan R.S., Parise H., Levy D., O'Connel C.J., D'Agostino R.B., et al. Mitral annular calcification predicts cardiovascular morbidity and mortality. The Framingham Heart Study. Circulation 2003, 107:1492-1496.
25. Allison M.A., Cheung P.B.S., Criqui M.H., Langer R.D., Wright C.M. Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis. Circulation 2006, 113:861-866.
26. Shindler D., Kostis Jb., Yusuf S., Quinones M.A., Pitt B., Stewart D., et al. Diabetes mellitus, a predictor of morbidity and mortality in the studies of the left ventricular dysfunction (SOLVD) trials and registry. Am J Cardiol 1996, 77:1017-1020.
27. Masoudi F.A., Inzucchi S.E. Diabetes mellitus and heart failure: epidemiology, mechanisms, and pharmacotherapy. Am J Cardiol 2007, 99:113B-132B.
28. Bobbio M., Ferrua S., Opasich C., Porcu M., Lucci D., Scherilo M., et al. BRING-UP Investigators. Survival and hospitalization in heart failure patients with or without diabetes treated with beta-blockers. J Card Fail 2003, 9:192-202.
29. Davis R.C., Hobbs F.D., Kenre J.E., Roalfe A.K., Hare R., Lancanshire R.J., et al. Prevalence of left ventricular systolic dysfunction and heart failure in high risk patients: community based epidemiological study. Br Med J 2002, 325:1156-1160.
30. Andersson C., Gislason G.H., Weeke P., Hoffmann S., Hansen P.R., Torp-Pedersen C., et al. Diabetes is associated with impaired myocardial performance in patients without significant coronary artery disease. Cardiovasc Diabetol 2010, 9:3. 10.1186/1475-2840-9-3.
31. Enande L., Begerot C., Rietzschel E.R., De Buyzere M.L., Thibault H., Pignonblanc P.G., et al. Diastolic dysfunction in patients with type 2 diabetes mellitus: is it really the first marker of diabetic cardiomyopathy?. J Am Soc Echocardiogr 2011, 24:1268-1275.
32. Vinereanu D., Mädler C.F., Gherginescu C., Ciobau A.O., Fraser A.G. Cumulative impact of cardiovascular risk factors on regional left ventricular function and reserve: progressive long-axis dysfunction with compensatory radial changes. Echocardiography 2012, 28:813-820.
33. Liu J.E., Palmieri V., Roman M.J., Bella J.N., Fabsitz R., Howard B.V., et al. The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the Strong Heart Study. J Am Coll Cardiol 2001, 37:1943-1949.
34. Masugata H., Senda S., Goda F., Yoshihara Y., Yoshikawa K., Fujita N., et al. Left ventricular diastolic dysfunction in normotensive diabetic patients in various age strata. Diabetes Res Clin Pract 2008, 79:91-96.
35. From A.M., Scott C.G., Chen H.H. Changes in diastolic dysfunction in diabetes mellitus over time. Am J Cardiol 2009, 103:1463-1466.
36. Kiencke S., Handschin R., von Dahlen R., Muser J., Brunner-Larocca H.P., Schumann J., et al. Pre-clinical diabetic cardiomyopathy: prevalence, screening and outcome. Eur J Heart Fail 2010, 12:951-957.
37. Patil V.C., Patil H.V., Shah K.B., Vasani J.D., Shetty P. Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function. J Cardiovasc Dis Res 2011, 2:213-222.
38. Giorda C.B., Cioffi G., De Simone G., Di lenarda A., Faggiano P., Latini R., et al. Predictors of left ventricular dysfunction in type 2 diabetes: results of DYDA study. Eur J Cardiovasc Prev Rehabil 2011, 18(3):415-423.
39. Berg T.J., Snorgaard O., Faber J., Torjesen P.A., Hildebrandt P., Mehlsen J., et al. Serum levels of advanced glycation end products are associated with left ventricular diastolic function in patients with type 1 diabetes. Diabetes Care 1999, 22:1186-1190.
40. Katz R., Wong N.D., Kronmal R., Takasu J., Shavelle D.M., Probstfield J.L., et al. Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis. Circulation 2006, 113:2113-2119.
41. Cioffi G., Faggiano P., Lucci D., Di Lenarda A., Mureddu G.F., Tarantini L., et al. Inappropriately high left ventricular mass in patients with type 2 diabetes mellitus and no overt cardiac disease. The DYDA study. J Hypertens 2011, 29:1994-2003.
42. Al-Aly Z., Shao J.S., Lai C.F., Huang E., Cai J., Behrmann A., et al. Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice. Arterioscler Thromb Vasc Biol 2007, 27:2589-2596.
43. Cioffi G., Gatti D., Adami S. Vitamin D deficiency, left ventricular dysfunction and heart failure. G Ital Cardiol 2010, 11:645-653.
44. Ren X., Shao H., Wei Q., Sun Z., Liu N. Advanced glycation end-products enhance calcification in vascular smooth muscle cells. J Int Med Res 2009, 37:847-854.
45. Chen Z.W., Qian J.Y., Jian Y., Ge L., Liu X.B., Shu X.H., et al. Prevalence and severity of coronary artery disease in diabetic patients with aortic valve calcification. Acta Cardiol 2011, 66:15-20.
46. De Marco M., de Simone G., Roman M.J., Chinali M., Lee E.T., Calhoun D., et al. Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study. Diabetes Care 2011, 34:2300-2305.
47. Mytas D.Z., Stouggianos P.N., Zairis M.N., Foussas S.G., Pyrgakis V.N., Kyriazis I.A. Diabetic myocardial disease. Pathophysiology, early diagnosis and therapeutic options. J Diabetes Complications 2009, 23:273-282.
48. Vintilla V.D., Roberts A., Vinereanu D., Fraser A.G. Progression of subclinical myocardial dysfunction in type 2 diabetes after 5 years despite improved glycemic control. Echocardiography 2012, 29:1045-1053.