Pathogenesis and significance of glomerular C4d deposition in lupus nephritis: Activation of classical and lectin pathways

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 10, 2013, Pages 2157-2167

  Kim, Min Kyung ^a   Maeng, Young In ^a   Lee, Sun Jae ^a   Lee, In Hee ^a   Bae, Jisuk ^a   Kang, Yu Na ^b   Park, Byung Tae ^a   Park, Kwan Kyu ^a  

^a Catholic University of Daegu   (South Korea)

^b Keimyung University   (South Korea)

Author keywords

C4d; Classical pathway; Disease activity; Lectin pathway; Lupus nephritis

Indexed keywords

COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C4D; LECTIN; PEPTIDE FRAGMENT;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLASSICAL PATHWAY; DISEASE ACTIVITY; FEMALE; GLOMERULUS; HUMAN; IMMUNOLOGY; LECTIN PATHWAY; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY; SYSTEMIC LUPUS ERYTHEMATOSUS;

C4D; CLASSICAL PATHWAY; DISEASE ACTIVITY; LECTIN PATHWAY; LUPUS NEPHRITIS;

ADOLESCENT; ADULT; CHILD; COMPLEMENT C4B; FEMALE; HUMANS; KIDNEY GLOMERULUS; LECTINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; RETROSPECTIVE STUDIES;

EID: 84885351064     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Tang S, Lui SL and Lai KN. Pathogenesis of lupus nephritis: an update. Nephrology (Carlton) 2005; 10: 174-179.
2. Murata K and Baldwin WM 3rd. Mechanisms of complement activation, C4d deposition, and their contribution to the pathogenesis of antibody-mediated rejection. Transplant Rev (Orlando) 2009; 23: 139-150.
3. Sato N, Ohsawa I, Nagamachi S, Ishii M, Kusaba G, Inoshita H, Toki A, Horikoshi S, Ohi H, Matsushita M and Tomino Y. Significance of glomerular activation of the alternative pathway and lectin pathway in lupus nephritis. Lupus 2011; 20: 1378-1386.
4. Manzi S, Ahearn JM and Salmon J. New insights into complement: a mediator of injury and marker of disease activity in systemic lupus erythematosus. Lupus 2004; 13: 298-303.
5. Batal I, Liang K, Bastacky S, Kiss LP, McHale T, Wilson NL, Paul B, Lertratanakul A, Ahearn JM, Manzi SM and Kao AH. Prospective assessment of C4d deposits on circulating cells and renal tissues in lupus nephritis: a pilot study. Lupus 2012; 21: 13-26.
6. Manzi S, Rairie JE, Carpenter AB, Kelly RH, Jagarlapudi SP, Sereika SM, Medsger TA Jr and Ramsey-Goldman R. Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity. Arthritis Rheum 1996; 39: 1178-1188.
7. Liu CC, Manzi S, Kao AH, Navratil JS, Ruffing MJ and Ahearn JM. Reticulocytes bearing C4d as biomarkers of disease activity for systemic lupus erythematosus. Arthritis Rheum 2005; 52: 3087-3099.
8. Muso E, Sekita K, Doi T, Kuwahara T, Yoshida H, Tamura T, Kawai C and Hamashima Y. Immunopathological correlation between mesangial C3d-deposition and C3d-fixing circulating immune complexes in lupus nephritis. Clin Immunol Immunopathol 1984; 32: 351-358.
9. Kao AH, Navratil JS, Ruffing MJ, Liu CC, Hawkins D, McKinnon KM, Danchenko N, Ahearn JM and Manzi S. Erythrocyte C3d and C4d for monitoring disease activity in systemic lupus erythematosus. Arthritis Rheum 2012; 62: 837-844.
10. Li SJ, Liu ZH, Zen CH, Wang QW, Wang Y and Li LS. Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection. Lupus 2007; 16: 875-880.
11. Kim SH and Jeong HJ. Glomerular C4d deposition indicates in situ classic complement pathway activation, but is not a marker for lupus nephritis activity. Yonsei Med J 2003; 44: 75-80.
12. Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA and Nagata M. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 2004; 15: 241-250.
13. Markowitz GS and D'Agati VD. Classification of lupus nephritis. Curr Opin Nephrol Hypertens 2009; 18: 220-225.
14. Austin HA 3rd, Muenz LR, Joyce KM, Antonovych TA, Kullick ME, Klippel JH, Decker JL and Balow JE. Prognostic factors in lupus nephritis. Contribution of renal histologic data. Am J Med 1983; 75: 382-391.
15. Austin HA 3rd, Muenz LR, Joyce KM, Antonovych TT and Balow JE. Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney Int 1984; 25: 689-695.
16. Monticielo OA, Mucenic T, Xavier RM, Brenol JC and Chies JA. The role of mannose-binding lectin in systemic lupus erythematosus. Clin Rheumatol 2008; 27: 413-419.
17. Fogo AB, Kashgarian M. Lupus nephritis. In: Diagnostic Atlas of Renal Pathology. Second edition. Elsevier Saunders, 2012; pp: 222-223.
18. Chantranuwat C, Qiao JH, Kobashigawa J, Hong L, Shintaku P and Fishbein MC. Immunoperoxidase staining for C4d on paraffin-embedded tissue in cardiac allograft endomyocardial biopsies: comparison to frozen tissue immunofluorescence. Appl Immunohistochem Mol Morphol 2004; 12: 166-171.
19. Feucht HE and Opelz G. The humoral immune response towards HLA class II determinants in renal transplantation. Kidney Int 1996; 50: 1464-1475.
20. Cohen D, Koopmans M, Kremer Hovinga IC, Berger SP, Roos van Groningen M, Steup-Beekman GM, de Heer E, Bruijn JA and Bajema IM. Potential for glomerular C4d as an indicator of thrombotic microangiopathy in lupus nephritis. Arthritis Rheum 2008; 58: 2460-2469.